scholarly journals Targeting the STING pathway in tumor-associated macrophages regulates innate immune sensing of gastric cancer cells

Theranostics ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 498-515 ◽  
Author(s):  
Lei Miao ◽  
Jingjing Qi ◽  
Qi Zhao ◽  
Qi-Nian Wu ◽  
Da-Liang Wei ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Innate Immune ◽  
Tumor Associated Macrophages ◽  
Gastric Cancer Cells ◽  
Immune Sensing ◽  
Sting Pathway ◽  
Innate Immune Sensing

scholarly journals The novel focal adhesion gene kindlin-2 promotes the invasion of gastric cancer cells mediated by tumor-associated macrophages

2012 ◽  
Vol 29 (2) ◽  
pp. 791-797 ◽  
Author(s):  
ZHANLONG SHEN ◽  
YINGJIANG YE ◽  
TUULI KAUTTU ◽  
HANNA SEPPÄNEN ◽  
SANNA VAINIONPÄÄ ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Focal Adhesion ◽  
The Novel ◽  
Tumor Associated Macrophages ◽  
Gastric Cancer Cells

scholarly journals Tumor-associated macrophages induce PD-L1 expression in gastric cancer cells through IL-6 and TNF-ɑ signaling

2020 ◽  
Vol 396 (2) ◽  
pp. 112315
Author(s):  
Xiaoli Ju ◽  
Heng Zhang ◽  
Zidi Zhou ◽  
Miao Chen ◽  
Qiang Wang
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Tumor Associated Macrophages ◽  
Gastric Cancer Cells

scholarly journals Extracellular vesicles shed from gastric cancer mediate protumor macrophage differentiation

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Atene Ito ◽  
Shunsuke Kagawa ◽  
Shuichi Sakamoto ◽  
Kazuya Kuwada ◽  
Hiroki Kajioka ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Ascitic Fluid ◽  
Extracellular Vesicles ◽  
Peritoneal Cavity ◽  
Peritoneal Dissemination ◽  
Tumor Associated Macrophages ◽  
Gastric Cancer Cells ◽  
Gastric Cancer Patients

Abstract Background Peritoneal dissemination often develops in gastric cancer. Tumor-associated macrophages (TAMs) are present in the peritoneal cavity of gastric cancer patients with peritoneal dissemination, facilitating tumor progression. However, the mechanism by which macrophages differentiate into tumor-associated macrophages in the peritoneal cavity is not well understood. In this study, the interplay between gastric cancer-derived extracellular vesicles (EVs) and macrophages was investigated. Methods The association between macrophages and EVs in peritoneal ascitic fluid of gastric cancer patients, or from gastric cancer cell lines was examined, and their roles in differentiation of macrophages and potentiation of the malignancy of gastric cancer were further explored. Results Immunofluorescent assays of the ascitic fluid showed that M2 macrophages were predominant along with the cancer cells in the peritoneal cavity. EVs purified from gastric cancer cells, as well as malignant ascitic fluid, differentiated peripheral blood mononuclear cell-derived macrophages into the M2-like phenotype, which was demonstrated by their morphology and expression of CD163/206. The macrophages differentiated by gastric cancer-derived EVs promoted the migration ability of gastric cancer cells, and the EVs carried STAT3 protein. Conclusion EVs derived from gastric cancer play a role by affecting macrophage phenotypes, suggesting that this may be a part of the underlying mechanism that forms the intraperitoneal cancer microenvironment.

Alpha-fetoprotein producing gastric cancer cells lack transcription factor AT-motif binding factor 1 (ATBF1)

2001 ◽  
Vol 120 (5) ◽  
pp. A31-A31
Author(s):  
H KATAOKA ◽  
T JOH ◽  
T OHSHIMA ◽  
Y ITOH ◽  
K SENOO ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Transcription Factor ◽  
Cancer Cells ◽  
Alpha Fetoprotein ◽  
Gastric Cancer Cells ◽  
Binding Factor
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