scholarly journals TGF-β inhibition combined with cytotoxic nanomedicine normalizes triple negative breast cancer microenvironment towards anti-tumor immunity

Theranostics ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 1910-1922 ◽  
Author(s):  
Myrofora Panagi ◽  
Chrysovalantis Voutouri ◽  
Fotios Mpekris ◽  
Panagiotis Papageorgis ◽  
Margaret R Martin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Immunity ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Cancer Microenvironment

scholarly journals Icariin‐induced inhibition of SIRT6/NF‐κB triggers redox mediated apoptosis and enhances anti‐tumor immunity in triple‐negative breast cancer

2020 ◽  
Vol 111 (11) ◽  
pp. 4242-4256
Author(s):  
Linjiang Song ◽  
Xian Chen ◽  
Ling Mi ◽  
Chi Liu ◽  
Shaomi Zhu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Immunity ◽  
Triple Negative Breast Cancer ◽  
Triple Negative

scholarly journals Cry1Ac Protoxin Confers Antitumor Adjuvant Effect in a Triple-Negative Breast Cancer Mouse Model by Improving Tumor Immunity

2022 ◽  
Vol 16 ◽  
pp. 117822342110651
Author(s):  
Servin-Garrido Roberto Raúl ◽  
Ilhuicatzi-Alvarado Damaris ◽  
Jiménez-Chávez Ángel de Jesús ◽  
Moreno-Fierros Leticia
Keyword(s):  
Breast Cancer ◽  
Mouse Model ◽  
Tumor Immunity ◽  
Triple Negative Breast Cancer ◽  
Cellular Response ◽  
Triple Negative ◽  
Vehicle Group ◽  
Cytotoxic T Cell ◽  
Adjuvant Effect ◽  
Cry1ac Toxin

The Cry1Ac protoxin from Bacillus thuringiensis is a systemic and mucosal adjuvant, able to confer protective immunity in different infection murine models and induce both Th1 and TCD8+ cytotoxic lymphocyte responses, which are required to induce antitumor immunity. The Cry1Ac toxin, despite having not being characterized as an adjuvant, has also proved to be immunogenic and able to activate macrophages. Here, we investigated the potential antitumor adjuvant effect conferred by the Cry1Ac protoxin and Cry1Ac toxin in a triple negative breast cancer (TNBC) murine model. First, we evaluated the ability of Cry1Ac proteins to improve dendritic cell (DC) activation and cellular response through intraperitoneal (i.p.) coadministration with the 4T1 cellular lysate. Mice coadministered with the Cry1Ac protoxin showed an increase in the number and activation of CD11c+MHCII- and CD11c+MHCII+low in the peritoneal cavity and an increase in DC activation (CD11c+MHCII+) in the spleen. Cry1Ac protoxin increased the proliferation of TCD4+ and TCD8+ lymphocytes in the spleen and mesenteric lymph nodes (MLN), while the Cry1Ac toxin only increased the proliferation of TCD4+ and TCD8+ in the MLN. Remarkably, when tested in the in vivo TNBC mouse model, prophylactic immunizations with 4T1 lysates plus the Cry1Ac protoxin protected mice from developing tumors. The antitumor effect conferred by the Cry1Ac protoxin also increased specific cytotoxic T cell responses, and prevented the typical tumor-related decrease of T cells (TCD3+ and TCD4+) as well the increase of myeloid-derived suppressor cells (MDSC) in spleen. Also in the tumor microenvironment of mice coadministered twice with Cry1Ac protoxin immunological improvements were found such as reductions in immunosupressive populations (T regulatory lymphocytes and MDSC) along with increases in macrophages upregulating CD86. These results show a differential antitumor adjuvant capability of Cry1Ac proteins, highlighting the ability of Cry1Ac protoxin to enhance local and systemic tumor immunity in TNBC. Finally, using a therapeutic approach, we evaluated the coadministration of Cry1Ac protoxin with doxorubicin. A significant reduction in tumor volume and lung metastasis was found, with increased intratumoral levels of tumor necrosis factor-α and IL-6 with respect to the vehicle group, further supporting its antitumor applicability.

scholarly journals A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment

Theranostics ◽  
2021 ◽  
Vol 11 (13) ◽  
pp. 6173-6192
Author(s):  
Lindsay B Alcaraz ◽  
Aude Mallavialle ◽  
Timothée David ◽  
Danielle Derocq ◽  
Frédéric Delolme ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Cathepsin D ◽  
Triple Negative ◽  
Cancer Microenvironment

scholarly journals Inhibition of Bone Marrow-Derived Mesenchymal Stem Cells Homing Towards Triple-Negative Breast Cancer Microenvironment Using an Anti-PDGFRβ Aptamer

Theranostics ◽  
2017 ◽  
Vol 7 (14) ◽  
pp. 3595-3607 ◽  
Author(s):  
Simona Camorani ◽  
Billy Samuel Hill ◽  
Raffaela Fontanella ◽  
Adelaide Greco ◽  
Matteo Gramanzini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Cancer Microenvironment

Abstract 1955: Investigating anti-tumor immunity with CDK4/6 inhibition in triple negative breast cancer

2021 ◽  
Author(s):  
Qiuchen Guo ◽  
Milos Spasic ◽  
Gregory Goreczny ◽  
Adam Maynard ◽  
Sandra McAllister
Keyword(s):  
Breast Cancer ◽  
Tumor Immunity ◽  
Triple Negative Breast Cancer ◽  
Triple Negative
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