scholarly journals Aldehyde dehydrogenase 1A1 confers erlotinib resistance via facilitating the reactive oxygen species-reactive carbonyl species metabolic pathway in lung adenocarcinomas

Theranostics ◽  
2019 ◽  
Vol 9 (24) ◽  
pp. 7122-7139 ◽  
Author(s):  
Hui-Min Lei ◽  
Ke-Ren Zhang ◽  
Cong Hui Wang ◽  
Yang Wang ◽  
Guang-Lei Zhuang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Aldehyde Dehydrogenase ◽  
Metabolic Pathway ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Reactive Carbonyl Species ◽  
Lung Adenocarcinomas ◽  
Carbonyl Species ◽  
Reactive Carbonyl

A novel multi-target strategy to attenuate the progression of Parkinson's disease by diamine hybrid AGE/ALE inhibitor

2021 ◽  
Author(s):  
N André Sasaki ◽  
Pascal Sonnet
Keyword(s):  
Reactive Oxygen Species ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Reactive Carbonyl Species ◽  
Vacuum Cleaning ◽  
Carbonyl Species ◽  
Reactive Carbonyl

Instead of a conventional ‘one-drug-one-target approach’, this article presents a novel multi-target approach with a concept of trapping simultaneously as many detrimental factors as possible involved in the progression of Parkinson's disease. These factors include reactive carbonyl species, reactive oxygen species, Fe3+/Cu2+ and ortho-quinones ( o-quinone), in particular. Different from the known multi-target strategies for Parkinson's disease, it is a sort of ‘vacuum cleaning’ strategy. The new agent consists of reactive carbonyl species scavenging moiety and reactive oxygen species scavenging and metal chelating moiety linked by a spacer. Provided that the capacity of scavenging o-quinones is demonstrated, this type of agent can further broaden its potential therapeutic profile. In order to support this new hypothetical approach, a number of simple in vitro experiments are proposed.

scholarly journals Reactive oxygen species and aldehyde dehydrogenase activity in Hodgkin lymphoma cells

2012 ◽  
Vol 92 (4) ◽  
pp. 606-614 ◽  
Author(s):  
Jun-ichiro Ikeda ◽  
Suhana Mamat ◽  
Tian Tian ◽  
Yi Wang ◽  
Wenjuan Luo ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Hodgkin Lymphoma ◽  
Dehydrogenase Activity ◽  
Aldehyde Dehydrogenase ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Lymphoma Cells ◽  
Aldehyde Dehydrogenase Activity

scholarly journals Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance

2004 ◽  
Vol 113 (3) ◽  
pp. 482-489 ◽  
Author(s):  
Karsten Sydow ◽  
Andreas Daiber ◽  
Matthias Oelze ◽  
Zhiqiang Chen ◽  
Michael August ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Aldehyde Dehydrogenase ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Cross Tolerance

Reactive oxygen species as a novel metabolic pathway for sperm DNA damage and Recurrent Pregnancy Loss

2017 ◽  
Author(s):  
Utsav K Radia ◽  
Channa N Jayasena ◽  
Monica Figueiredo ◽  
Larissa Franklin Revill ◽  
Anastasia Dimakopoulou ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Dna Damage ◽  
Metabolic Pathway ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Sperm Dna Damage ◽  
Sperm Dna
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