scholarly journals Focused ultrasound activates voltage-gated calcium channels through depolarizing TRPC1 sodium currents in kidney and skeletal muscle

Theranostics ◽  
2019 ◽  
Vol 9 (19) ◽  
pp. 5517-5531 ◽  
Author(s):  
Scott R. Burks ◽  
Rebecca M. Lorsung ◽  
Matthew E. Nagle ◽  
Tsang-Wei Tu ◽  
Joseph A. Frank
Keyword(s):  
Skeletal Muscle ◽  
Calcium Channels ◽  
Focused Ultrasound ◽  
Sodium Currents ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels

scholarly journals Focused ultrasound activates voltage-gated calcium channels through depolarizing TRPC1 sodium currents in kidney and skeletal muscle

Theranostics ◽  
2022 ◽  
Vol 12 (3) ◽  
pp. 1341-1341
Author(s):  
Scott R. Burks ◽  
Rebecca M. Lorsung ◽  
Matthew E. Nagle ◽  
Tsang-Wei Tu ◽  
Joseph A. Frank
Keyword(s):  
Skeletal Muscle ◽  
Calcium Channels ◽  
Focused Ultrasound ◽  
Sodium Currents ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels

scholarly journals γ1Subunit Interactions within the Skeletal Muscle L-type Voltage-gated Calcium Channels

2002 ◽  
Vol 278 (2) ◽  
pp. 1212-1219 ◽  
Author(s):  
Jyothi Arikkath ◽  
Chien-Chang Chen ◽  
Christopher Ahern ◽  
Valérie Allamand ◽  
Jason D. Flanagan ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Calcium Channels ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels

scholarly journals Structural insights into binding of STAC proteins to voltage-gated calcium channels

2017 ◽  
Vol 114 (45) ◽  
pp. E9520-E9528 ◽  
Author(s):  
Siobhan M. Wong King Yuen ◽  
Marta Campiglio ◽  
Ching-Chieh Tung ◽  
Bernhard E. Flucher ◽  
Filip Van Petegem
Keyword(s):  
Skeletal Muscle ◽  
Native American ◽  
Calcium Channels ◽  
Sh3 Domains ◽  
Mechanical Coupling ◽  
Voltage Gated ◽  
Ec Coupling ◽  
Voltage Gated Calcium Channels ◽  
Disease Variant ◽  
Structural Insights

Excitation–contraction (EC) coupling in skeletal muscle requires functional and mechanical coupling between L-type voltage-gated calcium channels (CaV1.1) and the ryanodine receptor (RyR1). Recently, STAC3 was identified as an essential protein for EC coupling and is part of a group of three proteins that can bind and modulate L-type voltage-gated calcium channels. Here, we report crystal structures of tandem-SH3 domains of different STAC isoforms up to 1.2-Å resolution. These form a rigid interaction through a conserved interdomain interface. We identify the linker connecting transmembrane repeats II and III in two different CaVisoforms as a binding site for the SH3 domains and report a crystal structure of the complex with the STAC2 isoform. The interaction site includes the location for a disease variant in STAC3 that has been linked to Native American myopathy (NAM). Introducing the mutation does not cause misfolding of the SH3 domains, but abolishes the interaction. Disruption of the interaction via mutations in the II–III loop perturbs skeletal muscle EC coupling, but preserves the ability of STAC3 to slow down inactivation of CaV1.2.

scholarly journals Presynaptic Paraneoplastic Disorders of the Neuromuscular Junction: An Update

2021 ◽  
Vol 11 (8) ◽  
pp. 1035
Author(s):  
Maria Pia Giannoccaro ◽  
Patrizia Avoni ◽  
Rocco Liguori
Keyword(s):  
Potassium Channels ◽  
Neuromuscular Junction ◽  
Calcium Channels ◽  
Myasthenia Gravis ◽  
Neuromuscular Transmission ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels ◽  
Immune Mediated ◽  
Recent Developments ◽  
Myasthenic Syndrome

The neuromuscular junction (NMJ) is the target of a variety of immune-mediated disorders, usually classified as presynaptic and postsynaptic, according to the site of the antigenic target and consequently of the neuromuscular transmission alteration. Although less common than the classical autoimmune postsynaptic myasthenia gravis, presynaptic disorders are important to recognize due to the frequent association with cancer. Lambert Eaton myasthenic syndrome is due to a presynaptic failure to release acetylcholine, caused by antibodies to the presynaptic voltage-gated calcium channels. Acquired neuromyotonia is a condition characterized by nerve hyperexcitability often due to the presence of antibodies against proteins associated with voltage-gated potassium channels. This review will focus on the recent developments in the autoimmune presynaptic disorders of the NMJ.

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