scholarly journals Knockdown of NEAT1 induces tolerogenic phenotype in dendritic cells by inhibiting activation of NLRP3 inflammasome

Theranostics ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 3425-3442 ◽  
Author(s):  
Maomao Zhang ◽  
Yang Zheng ◽  
Yong Sun ◽  
Shuang Li ◽  
Liangqi Chen ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Nlrp3 Inflammasome

scholarly journals Methotrexate enhances antigen presentation and maturation of tumour antigen-loaded dendritic cells through NLRP3 inflammasome activation: a strategy for dendritic cell-based cancer vaccine

2021 ◽  
Vol 13 ◽  
pp. 175883592098705
Author(s):  
Gao-Na Shi ◽  
Min Hu ◽  
Chengjuan Chen ◽  
Junmin Fu ◽  
Shuai Shao ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
Antigen Presentation ◽  
Nlrp3 Inflammasome ◽  
Tumour Antigen ◽  
Inflammasome Activation ◽  
Antigen Uptake ◽  
Nlrp3 Inflammasome Activation ◽  
Dc Maturation

Background: Dendritic cells (DCs) are antigen-presenting cells that play a pivotal role in adaptive cell-mediated immunity by priming and activating T cells against specific tumour and pathogenic antigens. Methotrexate (MTX), a folate derivative, functions as an immunoregulatory agent. However, the possible effect of MTX on tumour antigen-loaded DCs has not yet been investigated. Methods: We analysed the effect of MTX on the maturation and function of DCs along with tumour cell lysates (TCLs). Using bone marrow-derived DCs, we investigated the effect of MTX combined TCL-loaded DCs on T cells priming and proliferation. We also tested the anti-tumour immune effect on DCs when treated with MTX and/or TCL in vivo. Results: MTX combined with TCL not only enhanced DC maturation and stimulated cytokine release but also promoted CD8+ T cell activation and proliferation. The latter was associated with increased tumour antigen uptake and cross-presentation to T cells. Mechanistically, DC maturation and antigen presentation were partly modulated by NLRP3 inflammasome activation. Furthermore, immunisation of mice with MTX and TCL-pulsed DCs before a tumour challenge significantly delayed tumour onset and retarded its growth. This protective effect was due to priming of IFN-γ releasing CD8+ T cells and enhanced killing of tumour cells by cytotoxic T lymphocytes isolated from these immunised mice. Conclusion: MTX can function as a potent adjuvant in DC vaccines by increasing antigen presentation and T cell priming. Our findings provide a new strategy for the application of DC-based anti-tumour immunotherapy.

Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance

2012 ◽  
Vol 56 (8) ◽  
pp. 1212-1222 ◽  
Author(s):  
Clare M. Reynolds ◽  
Fiona C. McGillicuddy ◽  
Karen A. Harford ◽  
Orla M. Finucane ◽  
Kingston H. G. Mills ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Dendritic Cells ◽  
Nlrp3 Inflammasome ◽  
Saturated Fatty Acids

scholarly journals The NLRP3 inflammasome affects DNA damage responses after oxidative and genotoxic stress in dendritic cells

2013 ◽  
Vol 43 (8) ◽  
pp. 2126-2137 ◽  
Author(s):  
Ginevra Licandro ◽  
Hwei Ling Khor ◽  
Ottavio Beretta ◽  
Junyun Lai ◽  
Heidi Derks ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dendritic Cells ◽  
Nlrp3 Inflammasome ◽  
Genotoxic Stress ◽  
Dna Damage Responses

scholarly journals Withaferin A InhibitsHelicobacter pylori-induced Production of IL-1β in Dendritic Cells by Regulating NF-κB and NLRP3 Inflammasome Activation

2015 ◽  
Vol 15 (6) ◽  
pp. 269 ◽  
Author(s):  
Jae-Eun Kim ◽  
Jun-Young Lee ◽  
Min-Jung Kang ◽  
Yu-Jin Jeong ◽  
Jin-A Choi ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Nlrp3 Inflammasome ◽  
Withaferin A ◽  
Inflammasome Activation ◽  
Nlrp3 Inflammasome Activation

scholarly journals Rabies Virus Is Recognized by the NLRP3 Inflammasome and Activates Interleukin-1  Release in Murine Dendritic Cells

2013 ◽  
Vol 87 (10) ◽  
pp. 5848-5857 ◽  
Author(s):  
T. M. Lawrence ◽  
A. W. Hudacek ◽  
M. R. de Zoete ◽  
R. A. Flavell ◽  
M. J. Schnell
Keyword(s):  
Dendritic Cells ◽  
Rabies Virus ◽  
Nlrp3 Inflammasome ◽  
Interleukin 1

scholarly journals TLR2 and the NLRP3 inflammasome mediate IL-1β production in Prevotella nigrescens-infected dendritic cells

2021 ◽  
Vol 18 (2) ◽  
pp. 432-440
Author(s):  
Hye-Mi Jang ◽  
Ji-Yeon Park ◽  
Yeon-Ji Lee ◽  
Min-Jung Kang ◽  
Sung-Gang Jo ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Nlrp3 Inflammasome ◽  
Prevotella Nigrescens

scholarly journals Ion Efflux and Influenza Infection Trigger NLRP3 Inflammasome Signaling in Human Dendritic Cells

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Melissa Fernandez ◽  
Elizabeth Miller ◽  
Florian Krammer ◽  
Benjamin Greenbaum ◽  
Nina Bhardwaj
Keyword(s):  
Dendritic Cells ◽  
Nlrp3 Inflammasome ◽  
Influenza Infection ◽  
Ion Efflux ◽  
Human Dendritic Cells

scholarly journals Ion efflux and influenza infection trigger NLRP3 inflammasome signaling in human dendritic cells

2015 ◽  
Vol 99 (5) ◽  
pp. 723-734 ◽  
Author(s):  
Melissa Victoria Fernandez ◽  
Elizabeth Miller ◽  
Florian Krammer ◽  
Ramya Gopal ◽  
Benjamin D. Greenbaum ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Nlrp3 Inflammasome ◽  
Influenza Infection ◽  
Ion Efflux ◽  
Human Dendritic Cells

scholarly journals NLRP3 inflammasome-activating arginine-based liposomes promote antigen presentations in dendritic cells

2019 ◽  
Vol Volume 14 ◽  
pp. 3503-3516 ◽  
Author(s):  
Tianshu Li ◽  
Matthias Zehner ◽  
Jieyan He ◽  
Tomasz Próchnicki ◽  
Gabor Horvath ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Nlrp3 Inflammasome
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