scholarly journals Theranostic Nanodots with Aggregation-Induced Emission Characteristic for Targeted and Image-Guided Photodynamic Therapy of Hepatocellular Carcinoma

Theranostics ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 1264-1279 ◽  
Author(s):  
Yang Gao ◽  
Qi Chang Zheng ◽  
Shidang Xu ◽  
Youyong Yuan ◽  
Xiang Cheng ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Photodynamic Therapy ◽  
Emission Characteristic ◽  
Aggregation Induced Emission ◽  
Image Guided

A Light-Up Probe with Aggregation-Induced Emission for Real-Time Bio-orthogonal Tumor Labeling and Image-Guided Photodynamic Therapy

2018 ◽  
Vol 130 (32) ◽  
pp. 10339-10343 ◽  
Author(s):  
Fang Hu ◽  
Duo Mao ◽  
Kenry ◽  
Xiaolei Cai ◽  
Wenbo Wu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Real Time ◽  
Aggregation Induced Emission ◽  
Image Guided

Dual-targeted activatable photosensitizers with aggregation-induced emission (AIE) characteristics for image-guided photodynamic cancer cell ablation

2016 ◽  
Vol 4 (1) ◽  
pp. 169-176 ◽  
Author(s):  
Youyong Yuan ◽  
Shidang Xu ◽  
Chong-Jing Zhang ◽  
Ruoyu Zhang ◽  
Bin Liu
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Normal Cell ◽  
Aggregation Induced Emission ◽  
Image Guided ◽  
Cell Ablation

The currently available photosensitizers (PSs) for photodynamic therapy (PDT) can easily lead to undesirable normal cell death due to their intrinsic photo-toxicity and lack of selectivity for cancer cells.

One-Step Formulation of Targeted Aggregation-Induced Emission Dots for Image-Guided Photodynamic Therapy of Cholangiocarcinoma

ACS Nano ◽  
2017 ◽  
Vol 11 (4) ◽  
pp. 3922-3932 ◽  
Author(s):  
Min Li ◽  
Yang Gao ◽  
Youyong Yuan ◽  
Yuzhe Wu ◽  
Zifang Song ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Aggregation Induced Emission ◽  
Image Guided ◽  
One Step

scholarly journals Aggregation-Induced Emission (AIE) Polymeric Micelles for Imaging-Guided Photodynamic Cancer Therapy

Nanomaterials ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 921 ◽  
Author(s):  
Yang Zhang ◽  
Cai-Xia Wang ◽  
Shi-Wen Huang
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Plasma Membranes ◽  
Polymeric Micelles ◽  
Light Irradiation ◽  
Emission Characteristic ◽  
Noninvasive Treatment ◽  
Aggregation Induced Emission ◽  
Photodynamic Cancer Therapy

Photodynamic therapy (PDT) is a noninvasive treatment for selectively killing malignant tumor cells. The photosensitizer is a necessary component of photodynamic nanomedicine. Many efforts have been made to develop new photosensitizers for efficient cancer photodynamic therapy. In this work, we report a novel nano photosensitizer, polymeric micelles (AIE-M) with aggregation induced emission characteristic, for photodynamic cancer therapy. AIE-M with sub-20 nm particle size is prepared by the self-assembly of salicylaldazine-incorporated amphiphilic polymer (AIE-1), which can produce reactive oxygen species (ROS) with light irradiation in solution. After uptake by cancer cells, AIE-M can specially sojourn in plasma membranes of cancer cells at the early stage and predominantly accumulate in the mitochondria of cancer cell at the late stage. The phototoxicity of AIE-M, resulting from the generation of intracellular ROS with light irradiation, can efficiently cause cancer cells death by apoptosis and necrosis. The advantages of AIE-M as a nano photosensitizer include the small size, highly colloidal stability in the process of preparation and storage, and high cell penetration. The ultra-low Critical Micelle Concentration (CMC) of AIE-1, negligible dark toxicity and super phototoxicity of AIE-M suggest its promising potential for image-guided PDT.

scholarly journals Image-guided combination chemotherapy and photodynamic therapy using a mitochondria-targeted molecular probe with aggregation-induced emission characteristics

2015 ◽  
Vol 6 (8) ◽  
pp. 4580-4586 ◽  
Author(s):  
Chong-Jing Zhang ◽  
Qinglian Hu ◽  
Guangxue Feng ◽  
Ruoyu Zhang ◽  
Youyong Yuan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Combination Chemotherapy ◽  
Molecular Probe ◽  
Emission Characteristics ◽  
Aggregation Induced Emission ◽  
Image Guided

Mitochondria-targeted AIE photosensitizers show multifunctions of targeted and image-guided combination chemotherapy and photodynamic therapy.

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