scholarly journals miR-125a-5p ameliorates hepatic glycolipid metabolism disorder in type 2 diabetes mellitus through targeting of STAT3

Theranostics ◽  
2018 ◽  
Vol 8 (20) ◽  
pp. 5593-5609 ◽  
Author(s):  
Lina Xu ◽  
Yue Li ◽  
Lianhong Yin ◽  
Yan Qi ◽  
Huijun Sun ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycolipid Metabolism ◽  
Metabolism Disorder

Glycolipid metabolism and liver transcriptomic analysis of the therapeutic effects of pressed degreased walnut meal extracts on type 2 diabetes mellitus rats

2020 ◽  
Vol 11 (6) ◽  
pp. 5538-5552 ◽  
Author(s):  
Yulan Li ◽  
Dan Chen ◽  
Chengmei Xu ◽  
Qingyujing Zhao ◽  
Yage Ma ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Transcriptomic Analysis ◽  
Therapeutic Effects ◽  
Glycolipid Metabolism

WMP (extract of pressed degreased walnut meal) is rich in polyphenols which exhibit multiple therapeutic effects.

scholarly journals Hengshun Aromatic Vinegar Improves Glycolipid Metabolism in Type 2 Diabetes Mellitus via Regulating PGC-1α/PGC-1β Pathway

2021 ◽  
Vol 12 ◽  
Author(s):  
Guoquan Li ◽  
Xuemei Tan ◽  
Bao Zhang ◽  
Linshu Guan ◽  
Yidan Zhang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Hepg2 Cells ◽  
Regulatory Element ◽  
Glycogen Synthesis ◽  
Glucose Consumption ◽  
Glycolipid Metabolism ◽  
Liver And Kidney

Hengshun aromatic vinegar (HSAV), produced by typical solid-state or liquid-state fermentation techniques, is consumed worldwide as a food condiment. HSAV shows multiple bioactivities, but its activity in type 2 diabetes mellitus (T2DM) and possible mechanisms have not been reported. In this study, the effects of HSAV against T2DM were evaluated in insulin-induced HepG2 cells and high-fat diet (HFD) and streptozotocin (STZ) induced T2DM rats. Then, the mechanisms of HSAV against T2DM were explored by Real-time PCR, Western blot, immunofluorescence assays, siRNA transfection and gene overexpression experiments. Results indicated that HSAV significantly improved glucose consumption and reduced triglycerides (TG) contents in metabolic disordered HepG2 cells. Meanwhile, HSAV obviously alleviated general status, liver and kidney functions of T2DM rats, and decreased hyperglycemia and hyperlipidemia, improved insulin resistance, and reduced lipid accumulation in liver. Mechanism studies indicated that HSAV markedly down-regulated the expression of proliferator-activated receptor γ coactivator-1α (PGC-1α), then regulated peroxisome proliferators-activated receptor α (PPAR-α)/protein kinase B (AKT) signal pathway mediated gluconeogenesis and glycogen synthesis. Meanwhile, HSAV significantly up-regulated proliferator-activated receptor γ coactivator-1β (PGC-1β), and subsequently decreased sterol regulatory element binding protein-1c (SREBP-1c) pathway mediated lipogenesis. In conclusion, HSAV showed potent anti-T2DM activity in ameliorating dysfunction of glycolipid metabolism through regulating PGC-1α/PGC-1β pathway, which has a certain application prospect as an effective diet supplement for T2DM therapy in the future.

scholarly journals PHARMACIST COUNSELING EFFECT TO THE LEVEL OF PATIENT KNOWLEDGE WITH TYPE 2 DIABETES MELLITUS IN “KIMIA FARMA KAWI” PHARMACY, MALANG CITY

2017 ◽  
Vol 2 (2) ◽  
pp. 25
Author(s):  
Abdul Hakim ◽  
Ria Ramadhani Dwi Atmaja ◽  
Hajar Sugihantoro ◽  
Fahda Dina Mufidah
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Wilcoxon Test ◽  
P Value ◽  
Patient Knowledge ◽  
Metabolism Disorder ◽  
Pharmacist Counseling ◽  
Improve Patient

<p>Diabetes mellitus is a carbohydrates, fats, protein metabolism disorder that caused by impaired insulin secretion, insulin disruption or both. Diabetes mellitus sufferer need a special care to make the blood glucose level always in normal condition and no complications in various organs. Type 2 diabetes mellitus is inception of disease begins with development of key metabolic abnormality, insulin resistance. Causes of type 2 diabetes mellitus is obesity, age over 40, lifesyle, genetic suscetibility. Pharmacist counseling to the patients of type 2 diabetes mellitus is very important because it can improve patient knowledge, patient compliance to the treatment and the quality of patients life. The purpose of this study is to determine the effect of counseling by pharmacists to the level of patient’s knowledge of type 2 diabetes mellitus in “Kimia Farma Kawi” Pharmacy, Malang City.</p><p>This research is a quantitative study with <em>Pre-Experimental</em> design in the form of <em>pretest – post-test design</em>. Number of samples was taken during one month by using <em>consecutive sampling</em> method. The result of this study was using through <em>Wilcoxon test</em> that there was difference of value before and after the pharmacist counseling the patients of type 2 diabetes mellitus with significance value equal to 0.000 (p value &lt;0,05). The conclusion of this research is the pharmacist counseling can improve patient knowledge of type 2 diabetes mellitus.</p><p> </p><strong><em>Keywords</em></strong><em> : pharmacist counseling, knowledge, type 2 diabetes mellitus </em>

Sign in / Sign up

Export Citation Format

Share Document