scholarly journals Rewiring of cisplatin-resistant bladder cancer cells through epigenetic regulation of genes involved in amino acid metabolism

Theranostics ◽  
2018 ◽  
Vol 8 (16) ◽  
pp. 4520-4534 ◽  
Author(s):  
Austin Yeon ◽  
Sungyong You ◽  
Minhyung Kim ◽  
Amit Gupta ◽  
Myung Hee Park ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Amino Acid ◽  
Cancer Cells ◽  
Epigenetic Regulation ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Bladder Cancer Cells

Abstract 1002: Induced dependency on amino acid metabolism in proliferating cancer cells upon PKM2 activation

2012 ◽  
Author(s):  
Charles Kung ◽  
Shengfang Jin ◽  
Jeff Hixon ◽  
Stefan Gross ◽  
Yi Gao ◽  
...  
Keyword(s):  
Amino Acid ◽  
Cancer Cells ◽  
Amino Acid Metabolism ◽  
Acid Metabolism

scholarly journals Amino Acid Metabolism in Cancer Drug Resistance

Cells ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 140
Author(s):  
Hee-Chan Yoo ◽  
Jung-Min Han
Keyword(s):  
Drug Resistance ◽  
Amino Acid ◽  
Cancer Cells ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Epigenetic Modification ◽  
Redox Homeostasis ◽  
Resistance Mechanisms ◽  
Cancer Drug ◽  
Cancer Therapies

Despite the numerous investigations on resistance mechanisms, drug resistance in cancer therapies still limits favorable outcomes in cancer patients. The complexities of the inherent characteristics of tumors, such as tumor heterogeneity and the complicated interaction within the tumor microenvironment, still hinder efforts to overcome drug resistance in cancer cells, requiring innovative approaches. In this review, we describe recent studies offering evidence for the essential roles of amino acid metabolism in driving drug resistance in cancer cells. Amino acids support cancer cells in counteracting therapies by maintaining redox homeostasis, sustaining biosynthetic processes, regulating epigenetic modification, and providing metabolic intermediates for energy generation. In addition, amino acid metabolism impacts anticancer immune responses, creating an immunosuppressive or immunoeffective microenvironment. A comprehensive understanding of amino acid metabolism as it relates to therapeutic resistance mechanisms will improve anticancer therapeutic strategies.

Sulfur amino acid metabolism in doxorubicin-resistant breast cancer cells

2011 ◽  
Vol 255 (1) ◽  
pp. 94-102 ◽  
Author(s):  
Chang Seon Ryu ◽  
Hui Chan Kwak ◽  
Kye Sook Lee ◽  
Keon Wook Kang ◽  
Soo Jin Oh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Amino Acid ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Sulfur Amino Acid

Effect of oncogene activating mutations and kinase inhibitors on amino acid metabolism of human isogenic breast cancer cells

2015 ◽  
Vol 11 (12) ◽  
pp. 3378-3386 ◽  
Author(s):  
Eung-Sam Kim ◽  
Animesh Samanta ◽  
Hui Shan Cheng ◽  
Zhaobing Ding ◽  
Weiping Han ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Amino Acid ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Amino Acid Metabolism ◽  
Kinase Inhibitors ◽  
Acid Metabolism ◽  
Wild Type ◽  
Activating Mutations ◽  
Intracellular Amino Acid

K-Ras/PI3K knock-in mutation and treatment of kinase inhibitors altered the intracellular amino acid metabolism compared to the wild-type breast cell.

scholarly journals Metabolomic Profiling Reveals a Role for Androgen in Activating Amino Acid Metabolism and Methylation in Prostate Cancer Cells

PLoS ONE ◽  
2011 ◽  
Vol 6 (7) ◽  
pp. e21417 ◽  
Author(s):  
Nagireddy Putluri ◽  
Ali Shojaie ◽  
Vihas T. Vasu ◽  
Srilatha Nalluri ◽  
Shaiju K. Vareed ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Amino Acid ◽  
Cancer Cells ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Prostate Cancer Cells ◽  
Metabolomic Profiling

Amino Acid Metabolism

1979 ◽  
Vol 7 (1) ◽  
pp. 261-262
Author(s):  
E. V. ROWSELL
Keyword(s):  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism

758: Inflammatory and Anti-Inflammatory Regulators alter Levels of an Inhibitor of Apoptosis (IAP), Survivin, in T-24 Bladder Cancer Cells

2007 ◽  
Vol 177 (4S) ◽  
pp. 254-254
Author(s):  
Justin J. Cohen ◽  
Bayan T. Takizawa ◽  
Hristos Z. Kaimkliotis ◽  
David J. Rosenberg ◽  
Marcia A. Wheeler ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Inhibitor Of Apoptosis ◽  
Bladder Cancer Cells ◽  
Anti Inflammatory
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