scholarly journals Near-infrared Intraoperative Imaging of Thoracic Sympathetic Nerves: From Preclinical Study to Clinical Trial

Theranostics ◽  
2018 ◽  
Vol 8 (2) ◽  
pp. 304-313 ◽  
Author(s):  
Kunshan He ◽  
Jian Zhou ◽  
Fan Yang ◽  
Chongwei Chi ◽  
Hao Li ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Near Infrared ◽  
Intraoperative Imaging ◽  
Sympathetic Nerves ◽  
Preclinical Study

Laser therapy applications for osteoarthritis and chronic joint pain – A randomized placebo-controlled clinical trial

2012 ◽  
Vol 1 (4) ◽  
Author(s):  
Nelson Marquina ◽  
Roger Dumoulin-White ◽  
Arkady Mandel ◽  
Lothar Lilge
Keyword(s):  
Clinical Trial ◽  
Near Infrared ◽  
Continuous Wave ◽  
Laser System ◽  
Laser Diodes ◽  
Average Power ◽  
Evaluation Criteria ◽  
Adjunctive Treatment ◽  
Controlled Clinical Trial ◽  
Primary Evaluation

AbstractA randomized placebo-controlled clinical trial to evaluate an adjunctive treatment modality for pain associated with knee disorders was conducted utilizing a therapeutic laser system (low energy, non-surgical).The therapeutic laser system utilized a dual wavelength, multiple diode laser cluster probe with five super-pulsed 905 nm near-infrared (NIR) laser diodes, each emitting at 40 mW average power and four continuous wave 660 nm visible (VIS) red laser diodes, each emitting at 25 mW. It was used as an adjunctive modality providing 12 treatments, three times a week to a homogeneous patient population (n=126), in combination with standardized chiropractic techniques, to evaluate effectiveness on subjects presenting with osteoarthritis and knee pain. The primary endpoint was measured by the visual analog scale (VAS) to assess pain levels on a scale of 0–10. The success criteria for an individual patient in this study were identified as an improvement of 30% or more in the VAS from baseline to 12th treatment and/or an improvement of 20% or more in the VAS from baseline to 30-day follow-up evaluation.The data obtained in the study demonstrated that the present therapeutic laser system provided significant pain relief and osteoarthritic improvements in all primary evaluation criteria, with a statistical and clinical significance of

scholarly journals Extrahepatic biliary tract visualization using near-infrared fluorescence imaging with indocyanine green: optimization of dose and dosing time

2020 ◽  
Author(s):  
Qiangxing Chen ◽  
Rou Zhou ◽  
Jiefeng Weng ◽  
Yueyuan Lai ◽  
Hui Liu ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Bile Duct ◽  
Indocyanine Green ◽  
Near Infrared ◽  
Controlled Trial ◽  
Optimal Dose ◽  
Imaging Data ◽  
Time Points ◽  
Optimal Dosing ◽  
Real Time Identification

Abstract Background The dose and dosing time of indocyanine green (ICG) vary among fluorescence cholangiography (FC) studies. The purpose of this prospective, randomized, exploratory clinical trial was to optimize the dose and dosing time of ICG. Methods PubMed was searched to determine the optimal dose. To optimize the dosing time of ICG, a clinical trial was designed with two parts. The first part included patients with T tubes for more than 1 month. After the patient was injected with ICG, bile was collected at 10 time points to explore the change and trends of bile fluorescence intensity (FI). In addition, the results of the first experiment were used to setup a randomized controlled trial (RCT) that aimed to find the optimal dosing timing for ICG injections for laparoscopic cholecystectomy (LC). During surgery, imaging data were collected for analysis. Results After performing a systematic review, the ICG injection dose for each patient in the clinical trial was 10 mg. Five patients were included in the first part of the study. Bile collected 8 h after ICG injection had a higher FI than bile collected at other time points (p < 0.05), and the FI of bile collected 20 h after ICG injection was nearly zero. In the second part of the experiment, 4 groups of patients (6 patients per group) were injected with 10 mg ICG at 8, 10, 12 and 14 h prior to surgery. The distribution of bile duct FI (p = 0.001), liver FI (p < 0.001), and common bile duct (CBD)-to-liver contrast (p = 0.001) were not the same in each group. Further analysis with the Bonferroni method revealed the following: (1) the FI of the CBD in the 8 h group was significantly different from that in the 14 h group (adjusted p < 0.001); (2) the liver FI of the 8 h group was higher than that of the 10 h group (adjusted p = 0.042) and the 14 h group (adjusted p < 0.001); and (3) the CBD-to-liver contrast of the 8 h group was lower than that of the 10 h group (adjusted p = 0.013) and the 14 h group (adjusted p = 0.001). Conclusion ICG FC enables the real-time identification of extrahepatic bile ducts. The optimal effect of FC can be achieved by performing 10 mg ICG injections 10 to 12 h prior to surgery.

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