scholarly journals Inorganic Kernel-Reconstituted Lipoprotein Biomimetic Nanovehicles Enable Efficient Targeting “Trojan Horse” Delivery of STAT3-Decoy Oligonucleotide for Overcoming TRAIL Resistance

Theranostics ◽  
2017 ◽  
Vol 7 (18) ◽  
pp. 4480-4497 ◽  
Author(s):  
Kai Shi ◽  
Jianxiu Xue ◽  
Yan Fang ◽  
Hongshu Bi ◽  
Shan Gao ◽  
...  
Keyword(s):  
Trojan Horse ◽  
Trail Resistance ◽  
Decoy Oligonucleotide ◽  
Stat3 Decoy

scholarly journals First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy

2012 ◽  
Vol 2 (8) ◽  
pp. 694-705 ◽  
Author(s):  
Malabika Sen ◽  
Sufi M. Thomas ◽  
Seungwon Kim ◽  
Joanne I. Yeh ◽  
Robert L. Ferris ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Head And Neck ◽  
Head And Neck Tumors ◽  
Human Trial ◽  
Neck Tumors ◽  
Decoy Oligonucleotide ◽  
Stat3 Decoy

scholarly journals Lack of toxicity of a STAT3 decoy oligonucleotide

2008 ◽  
Vol 63 (6) ◽  
pp. 983-995 ◽  
Author(s):  
Malabika Sen ◽  
Patricia J. Tosca ◽  
Christa Zwayer ◽  
Michael J. Ryan ◽  
Jerry D. Johnson ◽  
...  
Keyword(s):  
Decoy Oligonucleotide ◽  
Stat3 Decoy

scholarly journals STAT3 decoy oligonucleotide-carrying microbubbles with pulsed ultrasound for enhanced therapeutic effect in head and neck tumors

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0242264
Author(s):  
Thiruganesh Ramasamy ◽  
Xucai Chen ◽  
Bin Qin ◽  
Daniel E. Johnson ◽  
Jennifer R. Grandis ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Tumor Progression ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Clinical Translation ◽  
Data Set ◽  
Decoy Oligonucleotide ◽  
Stat3 Decoy

Signal transducer and activator of transcription-3 (STAT3) is an oncogenic transcription factor implicated in carcinogenesis, tumor progression, and drug resistance in head and neck squamous cell carcinoma (HNSCC). A decoy oligonucleotide targeting STAT3 offers a promising anti-tumor strategy, but achieving targeted tumor delivery of the decoy with systemic administration poses a significant challenge. We previously showed the potential for STAT3 decoy-loaded microbubbles, in conjunction with ultrasound targeted microbubble cavitation (UTMC), to decrease tumor growth in murine squamous cell carcinoma. As a next step towards clinical translation, we sought to determine the anti-tumor efficacy of our STAT3 decoy delivery platform against human HNSCC and the effect of higher STAT3 decoy microbubble loading on tumor cell inhibition. STAT3 decoy was loaded on cationic lipid microbubbles (STAT3-MB) or loaded on liposome-conjugated lipid microbubbles to form STAT3-loaded liposome-microbubble complexes (STAT3-LPX). UTMC treatment efficacy with these two formulations was evaluated in vitro using viability and apoptosis assays in CAL33 (human HNSCC) cells. Anti-cancer efficacy in vivo was performed in a CAL33 tumor murine xenograft model. UTMC with STAT3-MB caused significantly lower CAL33 cell viability compared to UTMC with STAT3-LPX (56.8±8.4% vs 84.5±8.8%, respectively, p<0.05). In vivo, UTMC with STAT3-MB had strong anti-tumor effects, with significantly less tumor burden and greater survival compared to that of UTMC with microbubbles loaded with a mutant control decoy and untreated control groups (p<0.05). UTMC with STAT3 decoy-loaded microbubbles significantly decreases human HNSSC tumor progression. These data set the stage for clinical translation of our microbubble platform as an imaged-guided, targeted delivery strategy for STAT3 decoy, or other nucleotide-based therapeutics, in human cancer treatment.

Beware of ‘Trojan Horse Marketing’

2008 ◽  
Vol 39 (12) ◽  
pp. 14
Author(s):  
CHARLESE. CRUTCHFIELD
Keyword(s):  
Trojan Horse

Modern Day Trojan Horse

2020 ◽  
Vol 5 (1) ◽  
pp. 33-37
Author(s):  
Zahra Sina ◽  
Nadia Abdullahi
Keyword(s):  
Young Adults ◽  
Life Cycle ◽  
Daily Basis ◽  
Correlation Study ◽  
Trojan Horse ◽  
Female Students ◽  
Personal Hygiene ◽  
The Public

Personal hygiene products are used on a daily basis by many people. Many are comparable to the Trojan horse. On the outside, they appear to be harmless. They are contained in attractive bottles and they rely on misleading ads to attract consumers. However, these products may contain potentially harmful chemicals and many people are unaware of how individuals, societies and environments are affected in the various stages of the life cycle of many personal hygiene products. Our STSE issue deals with an everyday product that falls under the Trojan horse analogy–lotion. We are concerned that our peers and other young adults are purchasing lotions without the knowledge of how they came to stand on the shelves of a store. We conducted a correlation study between gender and popular lotion brands among teenagers and the reasons behind their choices. We came to the conclusion that more females than males were interested in popular lotion brands due to enticing features that targets mainly feminine interests (e.g. scent is an aspect of lotion that more females than males consider when purchasing the brand). For our actions, we prepared an educational mind-map on our issue and a video compilation where we interviewed female students on their reactions to various lotion brand commercials. Our actions are meant to inform the public about the controversies surrounding our issue and the techniques companies use to gain the attention of potential consumers.

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