scholarly journals Local Intratracheal Delivery of Perfluorocarbon Nanoparticles to Lung Cancer Demonstrated with Magnetic Resonance Multimodal Imaging

Theranostics ◽  
2018 ◽  
Vol 8 (2) ◽  
pp. 563-574 ◽  
Author(s):  
Lina Wu ◽  
Xiaofei Wen ◽  
Xiance Wang ◽  
Chunan Wang ◽  
Xilin Sun ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Magnetic Resonance ◽  
Multimodal Imaging ◽  
Intratracheal Delivery

scholarly journals Metabolic Signatures of Lung Cancer in Sputum and Exhaled Breath Condensate Detected by 1H Magnetic Resonance Spectroscopy: A Feasibility Study

2016 ◽  
Vol 9 ◽  
pp. MRI.S40864 ◽  
Author(s):  
Naseer Ahmed ◽  
Tedros Bezabeh ◽  
Omkar B. Ijare ◽  
Renelle Myers ◽  
Reem Alomran ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Magnetic Resonance ◽  
Cancer Patients ◽  
Exhaled Breath Condensate ◽  
Resonance Spectroscopy ◽  
Exhaled Breath ◽  
Lung Cancer Patients ◽  
Metabolic Biomarkers ◽  
Monitoring Treatment ◽  
Breath Condensate

Objectives Lung cancer is one of the most lethal cancers. Currently, there are no biomarkers for early detection, monitoring treatment response, and detecting recurrent lung cancer. We undertook this study to determine if 1H magnetic resonance spectroscopy (MRS) of sputum and exhaled breath condensate (EBC), as a noninvasive tool, can identify metabolic biomarkers of lung cancer. Materials and Methods Sputum and EBC samples were collected from 20 patients, comprising patients with pathologically confirmed non-small cell lung cancer ( n = 10) and patients with benign respiratory conditions ( n = 10). Both sputum and EBC samples were collected from 18 patients; 2 patients provided EBC samples only. 1H MR spectra were obtained on a Bruker Avance 400 MHz nuclear magnetic resonance (NMR) spectrometer. Sputum samples were further confirmed cytologically to distinguish between true sputum and saliva. Results In the EBC samples, median concentrations of propionate, ethanol, acetate, and acetone were higher in lung cancer patients compared to the patients with benign conditions. Median concentration of methanol was lower in lung cancer patients (0.028 mM) than in patients with benign conditions (0.067 mM; P = 0.028). In the combined sputum and saliva and the cytologically confirmed sputum samples, median concentrations of N-acetyl sugars, glycoprotein, propionate, lysine, acetate, and formate were lower in the lung cancer patients than in patients with benign conditions. Glucose was found to be consistently absent in the combined sputum and saliva samples (88%) as well as in the cytologically confirmed sputum samples (86%) of lung cancer patients. Conclusion Absence of glucose in sputum and lower concentrations of methanol in EBC of lung cancer patients discerned by 1H MRS may serve as metabolic biomarkers of lung cancer for early detection, monitoring treatment response, and detecting recurrence.

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