scholarly journals Quantitative Three-Dimensional Dynamic Contrast-Enhanced Ultrasound Imaging: First-In-Human Pilot Study in Patients with Liver Metastases

Theranostics ◽  
2017 ◽  
Vol 7 (15) ◽  
pp. 3745-3758 ◽  
Author(s):  
Ahmed El Kaffas ◽  
Rosa Maria Silveira Sigrist ◽  
George Fisher ◽  
Sunitha Bachawal ◽  
Joy Liau ◽  
...  
Keyword(s):  
Pilot Study ◽  
Liver Metastases ◽  
Ultrasound Imaging ◽  
Three Dimensional ◽  
Contrast Enhanced Ultrasound ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced

scholarly journals Assessment of sorafenib induced changes in tumor perfusion of uveal melanoma metastases with dynamic contrast-enhanced ultrasound (DCE-US)

2021 ◽  
Author(s):  
Dane Wildner ◽  
Lucie Heinzerling ◽  
Max E. Scheulen ◽  
Eckhart Kaempgen ◽  
Gerold Schuler ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Uveal Melanoma ◽  
Mean Transit Time ◽  
Prospective Trial ◽  
Early Response ◽  
Response To Treatment ◽  
Contrast Enhanced Ultrasound ◽  
Dynamic Contrast Enhanced ◽  
Sorafenib Therapy ◽  
Contrast Enhanced

Abstract Purpose Dynamic contrast-enhanced ultrasound (DCE-US) was used to monitor early response to sorafenib therapy in patients with liver metastases from uveal melanoma. Methods In total, 21 patients with liver metastases were recruited within a prospective trial and underwent daily sorafenib therapy. DCE-US of a target lesion was performed before initiation of treatment, on day 15 and 56. Two independent blinded investigators performed software analysis for DCE-US parameters and inter-observer-correlation was calculated. Response to treatment was evaluated on day 56. DCE-US parameters were correlated with clinical response and RECIST1.1 criteria. Results Inter-observer-correlation (r) of DCE-US parameters [time-to-peak (TTP), mean-transit-time (MTT), peak intensity (PI), regional blood volume (RBV), regional blood flow (RBF)] at baseline, day 15, and day 56 was highly significant (r-range 0.73–0.97, all p < 0.001). Out of 17 evaluable patients, 12 patients survived day 56 (clinical responders, cRE), whereas, five patients died before day 56 and were classified as non-responders (cNR). TTP values significantly increased in the cRE group 15 days after initiation of treatment for investigator 1 (p = 0.034) and at day 56 for both investigators (p = 0.028/0.028). MTT had increased significantly in the cRE group on day 56 (p = 0.037/0.022). In the cNR group changes for TTP and MTT remained insignificant. Thus, increase of the DCE-US parameters TTP and MTT are associated with response to treatment and prognosis. Conclusion An increase of TTP and MTT at frequent intervals could serve as a surrogate marker for early response evaluation to anti-angiogenic treatment of metastatic uveal melanoma.

scholarly journals Echo-Power Estimation from Log-Compressed Video Data in Dynamic Contrast-Enhanced Ultrasound Imaging

2013 ◽  
Vol 39 (10) ◽  
pp. 1826-1837 ◽  
Author(s):  
Thomas Payen ◽  
Alain Coron ◽  
Michele Lamuraglia ◽  
Delphine Le Guillou-Buffello ◽  
Emmanuel Gaud ◽  
...  
Keyword(s):  
Ultrasound Imaging ◽  
Power Estimation ◽  
Video Data ◽  
Contrast Enhanced Ultrasound ◽  
Compressed Video ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced

A multiparametric approach for dynamic contrast-enhanced ultrasound imaging of prostate cancer

2018 ◽  
Vol 17 (2) ◽  
pp. e1879-e1880
Author(s):  
R. Wildeboer ◽  
A. Postema ◽  
M. Kuenen ◽  
H. Wijkstra ◽  
M. Mischi
Keyword(s):  
Prostate Cancer ◽  
Ultrasound Imaging ◽  
Contrast Enhanced Ultrasound ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced
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