scholarly journals Elongated Nanoparticle Aggregates in Cancer Cells for Mechanical Destruction with Low Frequency Rotating Magnetic Field

Theranostics ◽  
2017 ◽  
Vol 7 (6) ◽  
pp. 1735-1748 ◽  
Author(s):  
Yajing Shen ◽  
Congyu Wu ◽  
Taro Q. P. Uyeda ◽  
Gustavo R. Plaza ◽  
Bin Liu ◽  
...  
2020 ◽  
Author(s):  
Maryam sadat Nezamtaheri ◽  
Seyed Peyman Shariatpanahi ◽  
Bahram Goliaei ◽  
Alireza Madjid Ansari

Abstract Background Extremely low-frequency magnetic field (ELF-MF) significantly induces apoptosis in cancer cells. To study the biological effects of the ELF-MF on tumor cells, we have designed and constructed a new exposure system that provides a uniform magnetic field with negligible temperature fluctuations during the exposure. Additionally, it provides ideal physiological conditions for live cells inside the incubator. This ELF-MF exposure system eliminates several limitations and disadvantages of other low frequency magnetic field systems; it generates a magnetic field with a frequency of 0 to 70 Hz with a maximum magnetic flux density of 150 mT. Methods The capabilities of the setup were examined using a 1 Hz, 100 mT magnetic field, at various exposure times, to induce apoptosis-mediated cell death in the MC4-L2 cell line. After exposure, apoptosis was assessed by flow cytometry. Results A biphasic response was observed in cells exposed to ELF-MF: at first a decreasing apoptotic rate during 2-12 hours exposure time was detected, after which apoptosis gradually increased during 24-120 hours of exposure. Conclusions We show that ELF-MF exposure with a frequency of 1 Hz and intensity of 100 mT induces apoptosis in MC4-L2 cancer cells in a time-dependent manner. These results show the significance of the long term studies of the ELF exposure effects.


2011 ◽  
Vol 222 ◽  
pp. 221-224 ◽  
Author(s):  
Ivars Javaitis ◽  
Vineta Zilgalve

A model of elastic magnetic filaments is developed, which allows investigating the dependence of filament dynamics on such physical parameters as magnetoelastic number (Cm), frequency of magnetic field, coefficient of friction, etc. By numerical simulation of the dynamics of filament shaping under the action of magnetic field it is shown that a characteristic U-like stable shape (hairpins) can form. Such a shape of filament can exist in the case of low-frequency rotating magnetic field. At the frequency increasing the U-like shape transforms to the S-like one. In the present work it is shown that in unsteady magnetic field a flexible magnetic filament “swims” in the direction of magnetic field.


Soft Matter ◽  
2017 ◽  
Vol 13 (36) ◽  
pp. 6259-6269 ◽  
Author(s):  
Shahab Boroun ◽  
Faïçal Larachi

Rotational movement of MNPs in ferrogels in an external rotating magnetic field for tuning mass transport.


2020 ◽  
Vol 83 (4) ◽  
Author(s):  
Handan Kayhan ◽  
Babek Erdebilli ◽  
Sevim Gönen ◽  
Meriç Arda Eşmekaya ◽  
Ersen Ertekin ◽  
...  

ACS Nano ◽  
2020 ◽  
Vol 14 (7) ◽  
pp. 8247-8256 ◽  
Author(s):  
Jan Vyskočil ◽  
Carmen C. Mayorga-Martinez ◽  
Eva Jablonská ◽  
Filip Novotný ◽  
Tomáš Ruml ◽  
...  

Theranostics ◽  
2017 ◽  
Vol 7 (13) ◽  
pp. 3326-3337 ◽  
Author(s):  
Irina V. Belyanina ◽  
Tatiana N. Zamay ◽  
Galina S. Zamay ◽  
Sergey S. Zamay ◽  
Olga S. Kolovskaya ◽  
...  

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