scholarly journals Cancer-derived Circulating MicroRNAs Promote Tumor Angiogenesis by Entering Dendritic Cells to Degrade Highly Complementary MicroRNAs

Theranostics ◽  
2017 ◽  
Vol 7 (6) ◽  
pp. 1407-1421 ◽  
Author(s):  
Jiaqi Wang ◽  
Huamao Ye ◽  
Dandan Zhang ◽  
Kai Cheng ◽  
Yijun Hu ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Tumor Angiogenesis ◽  
Circulating Micrornas ◽  
Promote Tumor Angiogenesis

Dendritic cells loading autologous tumor lysate promote tumor angiogenesis

Tumor Biology ◽  
2016 ◽  
Vol 37 (12) ◽  
pp. 15687-15695 ◽  
Author(s):  
Yi Yang ◽  
Jing Lu ◽  
Hangfan Liu ◽  
Guoguo Jin ◽  
Ruihua Bai ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Tumor Angiogenesis ◽  
Autologous Tumor ◽  
Tumor Lysate ◽  
Promote Tumor Angiogenesis

scholarly journals Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis

2002 ◽  
Vol 99 (15) ◽  
pp. 10031-10036 ◽  
Author(s):  
O. Goldshmidt ◽  
E. Zcharia ◽  
R. Abramovitch ◽  
S. Metzger ◽  
H. Aingorn ◽  
...  
Keyword(s):  
Cell Surface ◽  
Tumor Angiogenesis ◽  
Surface Expression ◽  
Cell Surface Expression ◽  
Promote Tumor Angiogenesis

Tumor suppression induced by intratumor administration of adenovirus vector expressing NK4, a 4-kringle antagonist of hepatocyte growth factor, and naive dendritic cells

Blood ◽  
2002 ◽  
Vol 100 (12) ◽  
pp. 3950-3959 ◽  
Author(s):  
Toshiaki Kikuchi ◽  
Makoto Maemondo ◽  
Koh Narumi ◽  
Kunio Matsumoto ◽  
Toshikazu Nakamura ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Growth Factor ◽  
Combination Therapy ◽  
Hepatocyte Growth Factor ◽  
Tumor Angiogenesis ◽  
Tumor Regression ◽  
Adenovirus Vector ◽  
Antagonistic Activity ◽  
Hepatocyte Growth

NK4, a 4-kringle antagonist of hepatocyte growth factor (HGF), is a potent inhibitor of tumor angiogenesis and functions independently of its HGF-antagonistic activity. We have shown previously that in vivo genetic modification of tumors with an adenovirus vector that expresses NK4 (AdNK4) restrains tumor angiogenesis and slows the rate of tumor growth in vivo. In the present study, we investigated the hypothesis that this can be made more efficient by also administering bone marrow–generated dendritic cells (DCs) to the tumor. The data show that the growth of mouse subcutaneous tumors is significantly suppressed by direct administration of DCs into established tumors that had been pretreated with AdNK4 3 days previously. The synergistic antitumor effect produced by the combination therapy of AdNK4 with DCs correlated with the in vivo priming of tumor-specific cytotoxic T lymphocytes. Analysis of mice treated with fluorescence-labeled DCs suggested that DCs injected into the flank tumor could migrate to lymphoid organs in vivo for activation of immune-relevant processes. Knockout mice experiments demonstrated that the tumor regression produced by this combination therapy depends on both major histocompatibility complex (MHC) class I antigen presentation of DCs injected into the tumors and CD8+ T cells of the treated host. Finally, a mechanism for this synergism was suggested by the histological observation that tumor necrosis and apoptosis were induced by genetic engineering of the tumors to express NK4. These findings should be useful in designing novel strategies that use a combination of 2 monotherapies directed against the vascular and immune systems for cancer therapy.

scholarly journals CD133+ liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling

Hepatology ◽  
2012 ◽  
Vol 55 (3) ◽  
pp. 807-820 ◽  
Author(s):  
Kwan Ho Tang ◽  
Stephanie Ma ◽  
Terence K. Lee ◽  
Yuen Piu Chan ◽  
Pak Shing Kwan ◽  
...  
Keyword(s):  
Liver Tumor ◽  
Tumor Angiogenesis ◽  
Interleukin 8 ◽  
Tumor Initiating Cells ◽  
Self Renewal ◽  
Promote Tumor Angiogenesis
Sign in / Sign up

Export Citation Format

Share Document