scholarly journals Aptamer-Mediated Transparent-Biocompatible Nanostructured Surfaces for Hepatocellular Circulating Tumor Cells Enrichment

Theranostics ◽  
2016 ◽  
Vol 6 (11) ◽  
pp. 1877-1886 ◽  
Author(s):  
Shuyi Wang ◽  
Chunxiao Zhang ◽  
Guozhou Wang ◽  
Boran Cheng ◽  
Yulei Wang ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Nanostructured Surfaces

scholarly journals Nanostructured Surfaces to Target and Kill Circulating Tumor Cells While Repelling Leukocytes

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Michael J. Mitchell ◽  
Carlos A. Castellanos ◽  
Michael R. King
Keyword(s):  
Cell Adhesion ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Cancer Cell ◽  
Halloysite Nanotubes ◽  
Breast Adenocarcinoma ◽  
Hematogenous Metastasis ◽  
Mcf7 Cells ◽  
Nanostructured Surfaces ◽  
Cancer Cell Death

Hematogenous metastasis, the process of cancer cell migration from a primary to distal location via the bloodstream, typically leads to a poor patient prognosis. Selectin proteins hold promise in delivering drug-containing nanocarriers to circulating tumor cells (CTCs) in the bloodstream, due to their rapid, force-dependent binding kinetics. However, it is challenging to deliver such nanocarriers while avoiding toxic effects on healthy blood cells, as many possess ligands that adhesively interact with selectins. Herein, we describe a nanostructured surface to capture flowing cancer cells, while preventing human neutrophil adhesion. Microtube surfaces with immobilized halloysite nanotubes (HNTs) and E-selectin functionalized liposomal doxorubicin (ES-PEG L-DXR) significantly increased the number of breast adenocarcinoma MCF7 cells captured from flow, yet also significantly reduced the number of captured neutrophils. Neutrophils firmly adhered and projected pseudopods on surfaces coated only with liposomes, while neutrophils adherent to HNT-liposome surfaces maintained a round morphology. Perfusion of both MCF7 cells and neutrophils resulted in primarily cancer cell adhesion to the HNT-liposome surface, and induced significant cancer cell death. This work demonstrates that nanostructured surfaces consisting of HNTs and ES-PEG L-DXR can increase CTC recruitment for chemotherapeutic delivery, while also preventing healthy cell adhesion and uptake of therapeutic intended for CTCs.

The impact of HER2 phenotype of circulating tumor cells in metastatic breast cancer: a study in 107 patients

2014 ◽  
Vol 74 (S 01) ◽  
Author(s):  
M Wallwiener ◽  
AD Hartkopf ◽  
S Riethdorf ◽  
J Nees ◽  
FA Taran ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Metastatic Breast ◽  
The Impact

EpCAM-independent enrichment approach for isolation of circulating tumor cells (CTCs) in breast cancer

2015 ◽  
Vol 75 (08) ◽  
Author(s):  
H Schneck ◽  
B Gierke ◽  
M Pawlak ◽  
M Templin ◽  
T Fehm ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells
Sign in / Sign up

Export Citation Format

Share Document