Repurposing of Anthelminthics as Anticancer Drugs

The combination of anticancer drugs in nanoparticles has great potential as a promising strategy to maximize efficacies by eradicating resistant, reduce the dosage of the drug and minimize toxicities on the normal cells. Gemcitabine (GEM), a nucleoside analogue, and atorvastatin (ATV), a cholesterol lowering agent, have shown anticancer effect with some limitations. The objective of this in vitro study was to evaluate the antitumor activity of the combination therapy of GEM and ATVencapsulated in a microemulsion (ME) formulation in the HCT116 colon cancer cells. The cytotoxicity and efficacy of the formulation were assessed by the 3- (4,5dimethylthiazole-2-yl)-2,5-diphyneltetrazolium bromide (MTT) assay. The mechanism of cell death was examined by observing the morphological changes of treated cells under light microscope, identifying apoptosis by using the ApopNexin apoptosis detection kit, and viewing the morphological changes in the chromatin structure stained with 4′,6-diamidino-2-phenylindole (DAPI) under the inverted fluorescence microscope. It has been found that reducing the concentration of GEM loaded on ME (GEM-ME) from 5μM to 1.67μM by combining it with 3.33μM of ATV in a ME formulation (GEM/2ATV-ME) has preserved the strong cytotoxicity of GEM-ME against HCT116 cells. The current study proved that formulating GEM with ATV in ME has improved the therapeutic potential of GEM and ATV as anticancer drugs.

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Highly Potent rhenium(I) Tricarbonyl Complexes with Dual Anticancer and Anti-Angiogenic Activity Against Colorectal Carcinoma

10.26434/chemrxiv.12012840.v1 ◽

2020 ◽

Cited By ~ 1

Author(s):

Joachim Delasoie ◽

Aleksandar Pavic ◽

Noémie Voutier ◽

Sandra Vojnovic ◽

Aurélien Crochet ◽

...

Keyword(s):

Colorectal Carcinoma ◽

Anticancer Drugs ◽

Xenograft Model ◽

Therapeutic Window ◽

Low Doses ◽

Sunitinib Malate ◽

Angiogenic Activity ◽

Antimetastatic Activity ◽

Clinical Drugs

Synthesized and characterized a series of rhenium(I) trycarbonyl-based complexes with increased lipophilicity. Two of these novel compounds were discovered to possess remarkable anticancer, anti-angiogenic and antimetastatic activity <i>in vivo</i> (zebrafish-human CRC xenograft model), being effective at very low doses (1-3 µM). At doses as high as 250 µM the complexes did not provoke toxicity issues encountered in clinical anticancer drugs (cardio-, hepato-, and myelotoxicity). The two compounds exceed the antiproliferative and anti-angiogenic potency of clinical drugs cisplatin and sunitinib-malate, and display a large therapeutic window.

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Faculty Opinions recommendation of Oral delivery of anticancer drugs I: general considerations.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717985925.793472135 ◽

2013 ◽

Author(s):

Gerald Shipps ◽

Xiaohua Huang

Keyword(s):

Anticancer Drugs ◽

Oral Delivery

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ABATEMENT OF ANTICANCER DRUGS VIA ELECTROCHEMICAL OXIDATION PROCESS: A REVIEW

10.37516/global.j.sci.eng.2020.010 ◽

2020 ◽

pp. 1-4

Author(s):

CHARULATA SIVODIA ◽

ALOK SINHA

Keyword(s):

Anticancer Drugs ◽

Cell Function ◽

Electrochemical Techniques ◽

Aquatic Organisms ◽

Pharmaceutical Drugs ◽

Cytostatic Drugs ◽

Cancerous Cell ◽

Pharmaceutical Removal ◽

Mutagenic Effects ◽

Made In

The advancement made in biomedical industry upsurges the consumption rate of pharmaceutical drugs. The lack of proper monitoring and regulation methods leads to the unregulated discharge of pharmaceuticals in wastewater, where it can affect the aquatic organisms. Anticancer drugs are also known as cytostatic drugs mainly used for the treatment of cancer by disrupting the cell function and prevent multiplication of cancerous cell. Therefore, anticancer drugs are suspected to pose potential risk on environment by influencing mutagenic effects on the cells of aquatic organisms. An extensive research has been already made in the field of pharmaceutical removal, however their application on the removal of anticancer drugs is limited. This review paper elucidates about different electrochemical techniques for the mitigation of cytostatic drugs.

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