scholarly journals Mild hyperthermia accelerates doxorubicin clearance from tumour-extravasated temperature-sensitive liposomes

2022 ◽  
Vol 6 (3) ◽  
pp. 230-242
Author(s):  
Wafa' T. Al-Jamal ◽  
Kostas Kostarelos
Keyword(s):  
Temperature Sensitive ◽  
Mild Hyperthermia

scholarly journals Biodistribution and Efficacy of Low Temperature-Sensitive Liposome Encapsulated Docetaxel Combined with Mild Hyperthermia in a Mouse Model of Prostate Cancer

2016 ◽  
Vol 33 (10) ◽  
pp. 2459-2469 ◽  
Author(s):  
Ashish Ranjan ◽  
Compton J. Benjamin ◽  
Ayele H. Negussie ◽  
Saurin Chokshi ◽  
Paul H. Chung ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Low Temperature ◽  
Mouse Model ◽  
Temperature Sensitive ◽  
Mild Hyperthermia

Anandamide modulates carotid sinus nerve afferent activity via TRPV1 receptors increasing responses to heat

2012 ◽  
Vol 112 (1) ◽  
pp. 212-224 ◽  
Author(s):  
Arijit Roy ◽  
Sravan Mandadi ◽  
Marie-Noelle Fiamma ◽  
Ekaterina Rodikova ◽  
Erin V. Ferguson ◽  
...  
Keyword(s):  
Carotid Body ◽  
Carotid Sinus ◽  
Ex Vivo ◽  
Null Mouse ◽  
Temperature Sensitive ◽  
Carotid Sinus Nerve ◽  
Afferent Activity ◽  
Mild Hyperthermia ◽  
Carotid Bodies ◽  
Trpv1 Receptors

Abnormal respiratory chemosensitivity is implicated in recurrent apnea syndromes, with the peripheral chemoreceptors, the carotid bodies, playing a particularly important role. Previous work suggests that supraphysiological concentrations of the endocannabinoid endovanilloid and TASK channel blocker anandamide (ANA) excite carotid bodies, but the mechanism(s) and physiological significance are unknown. Given that carotid body output is temperature-sensitive, we hypothesized that ANA stimulates carotid body chemosensory afferents via temperature-sensitive vanilloid (TRPV1) receptors. To test this hypothesis, we used the dual-perfused in situ rat preparation to confirm that independent perfusion of carotid arteries with supraphysiological concentrations of ANA strongly excites carotid sinus nerve afferents and that this activity is sufficient to increase phrenic activity. Next, using ex vivo carotid body preparations, we demonstrate that these effects are mediated by TRPV1 receptors, not CB1 receptors or TASK channels: in CB1-null mouse preparations, ANA increased afferent activity across all levels of Po2, whereas in TRPV1-null mouse preparations, the stimulatory effect of ANA was absent. In rat ex vivo preparations, ANA's stimulatory effects were mimicked by olvanil, a nonpungent TRPV1 agonist, and suppressed by the TRPV1 antagonist AMG-9810. The specific CB1 agonist oleamide had no effect. Physiological levels of ANA had no effect alone but increased sensitivity to mild hyperthermia. AMG-9810 blocked ANA's effect on the temperature response. Immunolabeling and RT-PCR demonstrated that TRPV1 receptors are not expressed in carotid body glomus cells but reside in petrosal sensory afferents. Together, these results suggest that ANA plays a physiological role in augmenting afferent responses to mild hyperthermia by activating TRPV1 receptors on petrosal afferents.

Oncogenesis and the Lucké Virus

1968 ◽  
Vol 26 ◽  
pp. 200-201
Author(s):  
A. E. Vatter ◽  
J. Zambernard
Keyword(s):  
Rna Viruses ◽  
Vegetative State ◽  
Temperature Sensitive ◽  
Structural Level ◽  
Oncogenic Viruses ◽  
Dna Viruses ◽  
Leopard Frogs ◽  
Renal Adenocarcinoma ◽  
Induced Tumors ◽  
Northern Leopard Frogs

Oncogenic viruses, like viruses in general, can be divided into two classes, those that contain deoxyribonucleic acid (DNA) and those that contain ribonucleic acid (RNA). The RNA viruses have been recovered readily from the tumors which they cause whereas, the DNA-virus induced tumors have not yielded the virus. Since DNA viruses cannot be recovered, the bulk of present day investigations have been concerned with RNA viruses.The Lucké renal adenocarcinoma is a spontaneous tumor which occurs in northern leopard frogs (Rana pipiens) and has received increased attention in recent years because of its probable viral etiology. This hypothesis was first advanced by Lucké after he observed intranuclear inclusions in some of the tumor cells. Tumors with inclusions were examined at the fine structural level by Fawcett who showed that they contained immature and mature virus˗like particles.The use of this system in the study of oncogenic tumors offers several unique features, the virus has been shown to contain DNA and it can be recovered from the tumor, also, it is temperature sensitive. This latter feature is of importance because the virus can be transformed from a latent to a vegetative state by lowering or elevating the environmental temperature.

THEORETICAL ELECTRON DENSITY AND TEMPERATURE SENSITIVE EMISSION LINE RATIOS FOR HELIUM-LIKE Si XIII COMPARED TO DITE TOKAMAK OBSERVATIONS

1989 ◽  
Vol 50 (C1) ◽  
pp. C1-559-C1-564
Author(s):  
F. P. KEENAN ◽  
R. BARNSLEY ◽  
J. DUNN ◽  
K. D. EVANS ◽  
S. M. McCANN ◽  
...  
Keyword(s):  
Emission Line ◽  
Electron Density ◽  
Temperature Sensitive ◽  
Electron Density And Temperature
Sign in / Sign up

Export Citation Format

Share Document