scholarly journals Long non-coding RNA NNT-AS1 positively regulates NPM1 expression to affect the proliferation of estrogen-mediated endometrial carcinoma by interacting

2022 ◽  
Vol 13 (1) ◽  
pp. 112-123
Author(s):  
Jie Shen ◽  
Xiaoping Feng ◽  
Hao Wang ◽  
Yanli Wang ◽  
Yunxiao Zhou
Keyword(s):  
Endometrial Carcinoma ◽  
Non Coding Rna ◽  
Long Non Coding Rna

The tumor suppressive effect of long non-coding RNA FRMD6-AS2 in uteri corpus endometrial carcinoma

Life Sciences ◽  
2020 ◽  
Vol 243 ◽  
pp. 117254 ◽  
Author(s):  
Jing Wang ◽  
Zenghui Li ◽  
Xiuli Wang ◽  
Yan Ding ◽  
Ning Li
Keyword(s):  
Endometrial Carcinoma ◽  
Suppressive Effect ◽  
Non Coding Rna ◽  
Long Non Coding Rna ◽  
Tumor Suppressive Effect

Long non-coding RNA HAND2-AS1 inhibits invasion and metastasis in endometrioid endometrial carcinoma through inactivating neuromedin U

2018 ◽  
Vol 413 ◽  
pp. 23-34 ◽  
Author(s):  
Xueying Yang ◽  
Chi Chiu Wang ◽  
Wayne Yuk Wai Lee ◽  
Jone Trovik ◽  
Tony Kwok Hung Chung ◽  
...  
Keyword(s):  
Endometrial Carcinoma ◽  
Invasion And Metastasis ◽  
Non Coding Rna ◽  
Endometrioid Endometrial Carcinoma ◽  
Long Non Coding Rna

scholarly journals Long non-coding RNA (lncRNA) HOXB-AS3 promotes cell proliferation and inhibits apoptosis by regulating ADAM9 expression through targeting miR-498-5p in endometrial carcinoma

2021 ◽  
Vol 49 (6) ◽  
pp. 030006052110135
Author(s):  
Ying Xing ◽  
Xianhua Sun ◽  
Feng Li ◽  
Xuan Jiang ◽  
Afang Jiang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Endometrial Carcinoma ◽  
Antisense Rna ◽  
Luciferase Reporter ◽  
Non Coding Rna ◽  
Proliferation And Apoptosis ◽  
Direct Target Gene ◽  
Ec Cells ◽  
Direct Target ◽  
Long Non Coding Rna

Objective Long non-coding RNA (lncRNA) expression is closely related to the pathogenesis and progression of various tumors. In this study, we investigated the mechanisms of lncRNA HOXB cluster antisense RNA 3 (HOXB-AS3), miRNA(miR)-498-5p, and disintegrin and metalloproteinase domain-containing protein 9 (ADAM9) in endometrial carcinoma (EC) cells. Methods The expression levels of lncRNA HOXB-AS3 in EC tissues and cells were detected using RT-qPCR assays. The effects of HOXB-AS3 knockdown on EC cell proliferation and apoptosis were measured using CCK-8 assays, colony formation assays, and flow cytometry. In addition, putative miR-498-5p binding sites were identified in HOXB-AS3 and ADAM9. The targeted relationships were further verified using dual-luciferase reporter and RNA pull-down assays. Results HOXB-AS3 expression was upregulated in EC tissues and cells. EC cell proliferation and viability decreased significantly in HOXB-AS3 knockdown groups. A putative miR-498-5p binding site in HOXB-AS3 was verified. Inhibition of miR-498-5p rescued the effects of HOXB-AS3 knockdown on cell proliferation and apoptosis. Finally, ADAM9 was verified as a direct target gene of miR-498-5p. Conclusions Our results suggest that lncRNA HOXB-AS3 is highly expressed in EC tissues and cells. Downregulation of HOXB-AS3 inhibits cell proliferation and promotes apoptosis in EC cells. HOXB-AS3 can upregulate ADAM9 expression by sponging miR-498-5p.

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