scholarly journals Preoperative LMR and Serum CA125 Level as Risk Factors for Advanced Stage of Ovarian Cancer

2021 ◽  
Vol 12 (19) ◽  
pp. 5923-5928
Author(s):  
Ying Tang ◽  
Hui-quan Hu ◽  
Ya-lan Tang ◽  
Fang-xiang Tang ◽  
Xue-mei Zheng ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ovarian Cancer ◽  
Advanced Stage ◽  
Ca125 Level ◽  
Serum Ca125 ◽  
Serum Ca125 Level

Significance of the Serum CA125 Level in Recurrent Ovarian Cancer

2010 ◽  
Vol 18 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Haruo Nishimura ◽  
Masamichi Tashiro ◽  
Kinya Hamaguchi ◽  
Yasuyuki Kiyozuka ◽  
Hiroshi Ide ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Recurrent Ovarian Cancer ◽  
Ca125 Level ◽  
Serum Ca125 ◽  
Serum Ca125 Level

Serum CA125 level before the development of ovarian cancer

2007 ◽  
Vol 99 (2) ◽  
pp. 95-99 ◽  
Author(s):  
H. Kobayashi ◽  
H. Ooi ◽  
Y. Yamada ◽  
M. Sakata ◽  
R. Kawaguchi ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Ca125 Level ◽  
Serum Ca125 ◽  
Serum Ca125 Level

scholarly journals Gynecological malignancies at tertiary care hospital, Pakistan: A five-year review

2021 ◽  
Vol 37 (3) ◽  
Author(s):  
Tayyiba Wasim ◽  
Javeria Mushtaq ◽  
Ahmad Zunair Wasim ◽  
Gul e Raana
Keyword(s):  
Risk Factors ◽  
Ovarian Cancer ◽  
Cervical Cancer ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Advanced Stage ◽  
Gynecological Malignancy ◽  
Abdominal Symptoms ◽  
Gynecological Malignancies

Background & Objective: Gynecological malignancies are important cause of female morbidity and mortality. They pose significant burden on health resources in low middle-income countries. Data on presentation and risk factors can help in early identification and reduce this burden. Our objective was to evaluate frequency, stage of presentation and risk factors of gynecological malignancies in a tertiary care setting. Methods: It was cross sectional study done in Gynecology Department, Services Institute of Medical Sciences, Services Hospital, Lahore from January 2015- December 2019. The records of the patients were retrospectively reviewed to include all cases of gynecologic malignancies. Demographic information, frequency, risk factors, symptoms, grade and stage of tumor was collected. Results: There were 122 patients diagnosed with gynecological malignancy during the study period. Ovarian cancer was seen in 60 (49.18%) patients followed by cervical cancer in 29(23.7%), endometrial cancer 27(22.1%) and vulva 06(4.9%). Mean age for all cancers was 51±12.7 to 55±9.3 except cervical cancer which was seen in 43±8.9 years. Patients with ovarian cancer had significantly more hypertension and diabetes (p<0.05). Heavy menstrual bleeding and postmenopausal bleeding was significantly seen in patients of endometrial and cervical cancer (p<0.05). Abdominal symptoms of pain, mass and distension were seen in patients with ovarian cancer (p<0.05). Majority patients presented in advanced stage. Among ovarian cancer, 52/60(86.6%) were epithelial in origin while 25(86.2%) cervical cancer and all vulva cancers were squamous cell carcinoma. Conclusion: Ovarian cancer was commonest gynecological malignancy followed by cervical cancer. Late presentation with advanced stage was seen in majority of all cancers. doi: https://doi.org/10.12669/pjms.37.3.3596 How to cite this:Wasim T, Mushtaq J, Wasim AZ, Gul-e-Raana. Gynecological malignancies at tertiary care hospital, Pakistan: A five-year review. Pak J Med Sci. 2021;37(3):---------. doi: https://doi.org/10.12669/pjms.37.3.3596 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Preoperative Lymphocyte-to-monocyte Ratio and CA125 Level as Risk Factors for Advanced Ovarian Cancer

2020 ◽  
Author(s):  
Ying Tang ◽  
Huiquan Hu ◽  
Yalan Tang ◽  
Fangxiang Tang ◽  
Dan Lin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ovarian Cancer ◽  
Logistic Regression ◽  
Early Stage ◽  
Advanced Ovarian Cancer ◽  
High Specificity ◽  
Advanced Stage ◽  
Binary Logistic Regression Model ◽  
Lymphocyte To Monocyte Ratio ◽  
The Relationship

Abstract Background: Detailed descriptions of the relationship between lymphocyte-to-monocyte ratio alone and combined with CA125 (COLC) and advanced stage of ovarian cancer (OC) have been lacking to date. This study is to analyze the relationship between LMR, CA125 and COLC and advanced stage of OC.Methods: A retrospective clinicopathologic review was performed. The receiver-operating characteristic (ROC) curves of LMR, CA125, and COLC staging OC were constructed. Furthermore, a binary logistic regression model was used to assay the independent risk factors.Results: A total of 225 patients with OC were identified in this cohort. Eighty-five patients with OC were diagnosed at an early stage, and 140 OC patients were diagnosed at an advanced stage. The median of LMR at the early stage was higher than the advanced stage (4.39 vs. 2.78), and the median of CA125 was lower than the advanced stage (80 U/mL vs. 251.25 U/mL). Multivariate logistic regression indicated that LMR (OR=0.314, 95% confidence interval [CI]: 0.143–0.687, P=0.004) and CA125 (OR=4.045, 95%CI: 1.883–8.692, P<0.001) were associated with OC staging. Furthermore, the area under the curve of COLC was higher than that of LMR (0.779 vs. 0.732) or CA125 (0.779 vs. 0.708) in staging OC. The specificity of COLC was higher than that of LMR (87.11% vs. 70.61%) or CA125 (87.11% vs. 61.21%) in staging OC.Conclusions: LMR alone or in combination with CA125 might be associated with OC staging. Besides, as a predictive factor, COLC may have high specificity in staging OC.

scholarly journals Diagnostic value of risk malignancy index (RMI) for detection of malignancies in clinically diagnosed ovarian masses and to evaluate the validity of individual constituent parameter of risk malignancy index

2019 ◽  
Vol 8 (4) ◽  
pp. 1558
Author(s):  
Jenitha B. ◽  
Subbiah M.
Keyword(s):  
Malignant Tumors ◽  
Menopausal Status ◽  
Research Centre ◽  
Ca 125 ◽  
Ovarian Mass ◽  
Individual Parameter ◽  
Ca125 Level ◽  
Serum Ca125 ◽  
Serum Ca125 Level ◽  
Ovarian Masses

Background: Pre-operative knowledge regarding the nature of ovarian mass is necessary in order to plan surgery. Risk malignancy index (RMI) is a simple scoring system based on three factors serum CA 125, USG score and menopausal status. The RMI was interpreted as 1) score >250=high risk, 2) 25-250=intermediate risk, 3) score <25=low risk. The objective of the study was to evaluate risk malignancy index (RMI) in pre-operatively clinically diagnosed ovarian mass and to compare the validity of individual parameter in RMI i.e. menopausal status, serum CA 125 and USG score to differentiate the nature of clinically diagnosed ovarian masses as benign or malignant.Methods: This was an observational study conducted in the Department of obstetrics and gynaecology, Trichy SRM Medical College and Research Centre, Trichy from January 2017 to January 2018 with a sample size of 77 cases with clinical diagnosis of ovarian mass admitted for surgery. The validity of RMI and validity of individual parameters were calculated and compared.Results: A total of 77 patients with ovarian tumors were enrolled in this study. According to the histological examination of the surgical specimens of the 77 women, 27.3% (n=21) had malignant tumors and 67.7% (n=56) had benign disease. Most common benign tumour was serous cystadenoma and the most common malignant tumour was mucinous cystadenocarcinoma. Among 77 patients, 42.85% (n=33) were postmenopausal, 44.15% (n=34) had USG score of 4, 27.27% (n=21) had serum CA125 level >cut-off values and 27.27% (n=21) had RMI >250. In cases where RMI>250, 18 out of 21 were malignant. In cases where USG score was 4, 19 out of 34 were malignant. Of the cases where serum CA125 level was > cut-off values 16 out of 21 were found to be malignant. RMI showed better sensitivity of 85.71%, specificity of 94.64%, PPV of 85.71%, NPV of 94.64% and diagnostic accuracy of 92.20%.Conclusions: RMI is highly valuable and reliable in differentiating benign and malignant ovarian lesions and facilitates selection of cases for conservative management and oncology referral.

Prechemotherapy serum CA125 level as a predictor of survival outcome in epithelial carcinoma of the ovary

1991 ◽  
Vol 3 (1) ◽  
pp. 32-36 ◽  
Author(s):  
N.G.P. Davidson ◽  
S. Khanna ◽  
P.H. Kirwan ◽  
D. Bircumshaw
Keyword(s):  
Survival Outcome ◽  
Ca125 Level ◽  
Serum Ca125 ◽  
Serum Ca125 Level ◽  
Carcinoma Of The Ovary
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