scholarly journals RNF114 Silencing Inhibits the Proliferation and Metastasis of Gastric Cancer

2022 ◽  
Vol 13 (2) ◽  
pp. 565-578
Author(s):  
Zongfeng Feng ◽  
Leyan Li ◽  
Qingwen Zeng ◽  
Yang Zhang ◽  
Yi Tu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Proliferation And Metastasis

HnRNPR/CCNB1/CENPF Axis Contributes to Gastric Cancer Proliferation and Metastasis

2019 ◽  
Author(s):  
Er-Bao Chen ◽  
Xuan Qin ◽  
Ke Peng ◽  
Qian Li ◽  
Cheng Tang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Proliferation ◽  
Proliferation And Metastasis

scholarly journals Long non‑coding RNA MIAT promotes gastric cancer proliferation and metastasis via modulating the miR‑331‑3p/RAB5B pathway

2020 ◽  
Vol 20 (6) ◽  
pp. 1-1
Author(s):  
Xiao-Mei Li ◽  
Yan-Yan Jiao ◽  
Bao-Hong Luan ◽  
Hong-Xia Wu ◽  
Rong-Rong Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Proliferation ◽  
Non Coding Rna ◽  
Proliferation And Metastasis ◽  
Long Non Coding Rna

scholarly journals PI3K/AKT/β-Catenin Signaling Regulates Vestigial-Like 1 Which Predicts Poor Prognosis and Enhances Malignant Phenotype in Gastric Cancer

Cancers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1923 ◽  
Author(s):  
Bo-Kyung Kim ◽  
Jae-Ho Cheong ◽  
Joo-Young Im ◽  
Hyun Seung Ban ◽  
Seon-Kyu Kim ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Target Genes ◽  
Prognostic Biomarker ◽  
Xenograft Model ◽  
Gastric Cancer Cells ◽  
Metastatic Lesions ◽  
Proliferation And Metastasis ◽  
Cancer Tissues ◽  
Sphere Formation

Although gastric cancer is a common cause of cancer mortality worldwide, its biological heterogeneity limits the available therapeutic options. Therefore, identifying novel therapeutic targets for developing effective targeted therapy of gastric cancer is a pressing need. Here, we investigate molecular function and regulatory mechanisms of Vestigial-like 1 (VGLL1) in gastric cancer. Microarray analysis of 556 gastric cancer tissues revealed that VGLL1 was a prognostic biomarker that correlated with PI3KCA and PI3KCB. VGLL1 regulates the proliferation of gastric cancer cells, as shown in live cell imaging, sphere formation, and in vivo xenograft model. Tail vein injection of NUGC3 cells expressing shVGLL1 resulted in less lung metastasis occurring when compared to the control. In contrast, larger metastatic lesions in lung and liver were detected in the VGLL1-overexpressing NUGC3 cell xenograft excision mouse model. Importantly, VGLL1 expression is transcriptionally regulated by the PI3K-AKT-β-catenin pathway. Subsequently, MMP9, a key molecule in gastric cancer, was explored as one of target genes that were transcribed by VGLL1-TEAD4 complex, a component of the transcription factor. Taken together, PI3K/AKT/β-catenin signaling regulates the transcription of VGLL1, which promotes the proliferation and metastasis in gastric cancer. This finding suggests VGLL1 as a novel prognostic biomarker and a potential therapeutic target.

LncRNA PCAT18/miR-301a/TP53INP1 axis is involved in gastric cancer cell viability, migration and invasion

2020 ◽  
Vol 168 (5) ◽  
pp. 547-555
Author(s):  
Jin Dou ◽  
Daoyuan Tu ◽  
Haijian Zhao ◽  
Xiaoyu Zhang
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Cell Viability ◽  
Cell Lines ◽  
Underlying Mechanism ◽  
Migration And Invasion ◽  
Invasion And Migration ◽  
Proliferation And Metastasis ◽  
And Migration ◽  
Cell Proliferation And Metastasis

Abstract MiR-301a is as an oncogene involved in the regulation of gastric cancer (GC) progression, but the underlying mechanism is unclear. This study was to explore the lncRNA PCAT18/miR-301a/TP53INP1 axis in regulating the GC cell proliferation and metastasis. In the present study, GC tissues and cell lines were collected for the detection of PCAT18 expression. Herein, we found that PCAT18 is significantly decreases in human GC tissues and five GC cell lines. Overexpression of PCAT18 inhibits cell viability, invasion and migration of GC cells and tumour growth of GC xenograft tumours. PCAT18 negatively regulates the expression level of miR-301a. The interaction between PCAT18 and miR-301a is confirmed by RIP and RNA pull down. MiR-301a mimic increases cell viability and promotes cell migration and invasion and reverses the inhibitory action of PCAT18. TP53INP1 expression is negatively regulated by miR-301a and TP53INP1/miR-301a is involved in GC viability, migration and invasion. The promoting of PCAT18 on TP53INP1 expression is abolished by miR-301a overexpression. In conclusion, lncRNA PCAT18 acts as a tumour suppressor for GC and lncRNA PCAT18, miR-301a and TP53INP1 comprise a signal axis in regulating GC cell proliferation, migration and invasion.

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