scholarly journals Overexpression of TMEFF1 in Endometrial Carcinoma and the Mechanism Underlying its Promotion of Malignant Behavior in Cancer Cells

2021 ◽  
Vol 12 (19) ◽  
pp. 5772-5788
Author(s):  
Xin Nie ◽  
Lingling Gao ◽  
Mingjun Zheng ◽  
Caixia Wang ◽  
Shuang Wang ◽  
...  
Keyword(s):  
Endometrial Carcinoma ◽  
Cancer Cells ◽  
Malignant Behavior

scholarly journals A Feedback Loop Regulation Of LINC01433 And YAP Promotes Malignant Behavior In Gastric Cancer Cells

2019 ◽  
Vol Volume 12 ◽  
pp. 7949-7962 ◽  
Author(s):  
Cao Zhang ◽  
Haiquan Qian ◽  
Ke Liu ◽  
Wei Zhao ◽  
Lei Wang
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Feedback Loop ◽  
Gastric Cancer Cells ◽  
Malignant Behavior

LncRNA LINC00470 promotes the degradation of PTEN mRNA to facilitate malignant behavior in gastric cancer cells

2020 ◽  
Vol 521 (4) ◽  
pp. 887-893 ◽  
Author(s):  
Jijun Yan ◽  
Xiufang Huang ◽  
Xiongjie Zhang ◽  
Zhijie Chen ◽  
Chao Ye ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Gastric Cancer Cells ◽  
Pten Mrna ◽  
Malignant Behavior

scholarly journals GRSF1-mediated MIR-G-1 promotes malignant behavior and nuclear autophagy by directly upregulating TMED5 and LMNB1 in cervical cancer cells

Autophagy ◽  
2018 ◽  
Vol 15 (4) ◽  
pp. 668-685 ◽  
Author(s):  
Zhen Yang ◽  
Qi Sun ◽  
Junfei Guo ◽  
Shixing Wang ◽  
Ge Song ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Cervical Cancer Cells ◽  
Malignant Behavior

Models of Hormone Regulation of Cancer Cells: Endometrial Carcinoma

1995 ◽  
pp. 1-21
Author(s):  
Miguel Beato ◽  
Gerd Helftenbein ◽  
Jörg Klug ◽  
Andrea Sandmöller ◽  
Axel Scholz ◽  
...  
Keyword(s):  
Endometrial Carcinoma ◽  
Cancer Cells ◽  
Hormone Regulation

Overexpression of MYB is associated with growth and malignant behavior of ovarian cancer cells

2018 ◽  
Vol 149 ◽  
pp. 63-64
Author(s):  
O. Miree ◽  
S.K. Srivastava ◽  
S. Singh ◽  
J.M. Scalici ◽  
J.E. Carter ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Malignant Behavior

Lentivirus-Mediated RNA Interference Targeting the Long Noncoding RNA HOTAIR Inhibits Proliferation and Invasion of Endometrial Carcinoma Cells In Vitro and In Vivo

2014 ◽  
Vol 24 (4) ◽  
pp. 635-642 ◽  
Author(s):  
Jiaming Huang ◽  
Peiqi Ke ◽  
Luyan Guo ◽  
Wei Wang ◽  
Hao Tan ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Endometrial Cancer ◽  
Endometrial Carcinoma ◽  
Cancer Cells ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Proliferation And Invasion

ObjectiveThe overexpression of long noncoding RNA HOTAIR is associated with various aggressive solid carcinomas. However, its relationship with endometrial carcinoma has not been reported. The present study aimed to investigate the expression of the long noncoding RNA HOTAIR in endometrial carcinoma, its relationship with the carcinoma’s clinicopathologic features, and the biological function of HOTAIR in regulating endometrial cancer cell proliferation and invasion in vitro and in vivo.MethodsThe expression of HOTAIR was detected in different tissues and cell lines by real-time PCR. Lentivirus-mediated HOTAIR-specific shRNAvectors were transfected into endometrial cancer HEC-1A cells. Cell proliferation and colony formation were examined by CCK-8 assays and colony formation assays, respectively. Invasion and migration were examined by Transwell assays. Flow cytometry assay was used to examine the cell cycle. In addition, xenograft model assays were performed to analyze the growth of endometrial cancer cells in vivo.ResultsOur data showed that HOTAIR expression was higher in endometrial cancer cells and tissues than in normal endometrial tissues. HOTAIR expression was closely related to the tumor stage (P= 0.045), myometrial invasion (P= 0.014), and lymph node metastasis (P= 0.033). The down-regulation of HOTAIR resulted in a significant inhibition of cell proliferation, migration, and invasion and in cell cycle arrest at the G0/G1 phase. Furthermore, HOTAIR depletion significantly suppressed the endometrial cancer tumorigenesis in vivo.ConclusionsThis study is the first to suggest that HOTAIR plays an important role in the carcinogenesis of endometrial cancer. Targeting HOTAIR may be a novel therapeutic strategy for endometrial cancer.

scholarly journals CREB1 acts via the miR‑922/ARID2 axis to enhance malignant behavior of liver cancer cells

2021 ◽  
Vol 45 (5) ◽  
Author(s):  
Xinyu Liu ◽  
Hao Zhang ◽  
Pengcheng Zhou ◽  
Yaqun Yu ◽  
Haoye Zhang ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Liver Cancer Cells ◽  
Malignant Behavior
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