scholarly journals LncRNA SNHG14 promotes cell proliferation and invasion in colorectal cancer through modulating miR-519b-3p/DDX5 axis

2021 ◽  
Vol 12 (16) ◽  
pp. 4958-4970
Author(s):  
Xiaoyuan Wang ◽  
Peng Yang ◽  
Dongsheng Zhang ◽  
Ming Lu ◽  
Chi Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Proliferation And Invasion

scholarly journals MicroRNA-362 Inhibits Cell Proliferation and Invasion by Directly Targeting SIX1 in Colorectal Cancer

2019 ◽  
Vol 60 (5) ◽  
pp. 414 ◽  
Author(s):  
Jin'e Wan ◽  
Jian Yang ◽  
Cuixia Qiao ◽  
Xiaomei Sun ◽  
Aiting Di ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Proliferation And Invasion

scholarly journals Promotion of Tumor Growth by ADAMTS4 in Colorectal Cancer: Focused on Macrophages

2018 ◽  
Vol 46 (4) ◽  
pp. 1693-1703 ◽  
Author(s):  
Jianjun Chen ◽  
Yang Luo ◽  
Yong Zhou ◽  
Shaolan Qin ◽  
Yier Qiu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Tumor Growth ◽  
Expression Profile ◽  
Copy Number ◽  
Copy Number Alterations ◽  
Extracellular Proteases ◽  
Proliferation And Invasion

Background/Aims: ADAMTSs (A disintegrin and metalloprotease domains with thrombospondins motifs) are a family of extracellular proteases that have been related to both oncogenic and tumor-suppressive functions. The aim of the present study was to investigate: 1) the mutation, copy-number alterations, and expression profile of ADAMTSs in colorectal cancer and 2) whether ADAMTSs participate in colorectal cancer (CRC) progression and invasion. Methods: The mutation, copy-number alterations, and expression profile of ADAMTSs in CRC were analyzed in the TCGA cohort using cBioportal. ADAMTS4 expression in tumor tissues and cell lines were determined by immunostaining and real-time quantitative PCR. The role of ADAMTS-4 in CRC progression and the underlying mechanisms were studied by using short hairpin RNA-mediated knockdown of ADAMTS4. The effects of ADAMTS4 in cell proliferation and invasion were determined by clone formation assay and transwell migration assay, respectively. Macrophages were depleted by liposomal clodronate in immune-competent BALB/c mice and tumor growth was analyzed. Results: ADAMTS4 was differentially expressed in CRC and predicted a poor prognosis. Elevated ADAMTS4 expression was closely associated with larger tumor size, enhanced TNM stage, and a poor clinical outcome in patients with CRC. ADAMTS4 knockdown had no inhibitory implications on cell proliferation and invasion in vitro, but significantly attenuated tumor growth in vivo. Mechanistically, we revealed that ADAMTS4 was associated macrophages infiltration and polarization in the tumor microenvironment of CRC. Macrophage depletion largely abolished the promotive effect of ADAMTS4 on tumor growth in the immune competent BALB/c mice. Conclusion: ADAMTS4 seemed to be a promising prognostic indicator in CRC. The novel link between ADAMTS4 and macrophages mirrors the potential regulatory roles of ADAMTSs in the inflammatory microenvironment of cancers.

scholarly journals MicroRNA 345, a methylation-sensitive microRNA is involved in cell proliferation and invasion in human colorectal cancer

2011 ◽  
Vol 32 (8) ◽  
pp. 1207-1215 ◽  
Author(s):  
Jie-Ting Tang ◽  
Ji-Lin Wang ◽  
Wan Du ◽  
Jie Hong ◽  
Shu-Liang Zhao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Human Colorectal Cancer ◽  
Proliferation And Invasion

Catechol-O-Methyltransferase Inhibits Colorectal Cancer Cell Proliferation and Invasion

2015 ◽  
Vol 46 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Wenming Wu ◽  
Qiao Wu ◽  
Xiafei Hong ◽  
Guangbing Xiong ◽  
Yi Xiao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Colorectal Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Proliferation And Invasion
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