scholarly journals The Tumor Microenvironment Contribution to Development, Growth, Invasion and Metastasis of Head and Neck Squamous Cell Carcinomas

2013 ◽  
Vol 4 (1) ◽  
pp. 66-83 ◽  
Author(s):  
Sittichai Koontongkaew
Keyword(s):  
Tumor Microenvironment ◽  
Head And Neck ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Invasion And Metastasis

The tumor microenvironment in head and neck squamous cell carcinomas: Predictive value and clinical relevance of molecular markers

2007 ◽  
Vol 82 ◽  
pp. S27-S28
Author(s):  
I.J. Hoosteen ◽  
K.I. Wijffels ◽  
H.A.M. Marres ◽  
F.J.A. van den Hoogen ◽  
A.J. van der Kogel ◽  
...  
Keyword(s):  
Molecular Markers ◽  
Tumor Microenvironment ◽  
Head And Neck ◽  
Squamous Cell ◽  
Predictive Value ◽  
Clinical Relevance ◽  
Squamous Cell Carcinomas

scholarly journals Potential Therapeutic Significance of Laminin in Head and Neck Squamous Carcinomas

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1890
Author(s):  
Nathalia Meireles Da Costa ◽  
Fábio A. Mendes ◽  
Bruno Pontes ◽  
Luiz Eurico Nasciutti ◽  
Luis Felipe Ribeiro Pinto ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Head And Neck ◽  
Squamous Cell ◽  
Mapk Signaling ◽  
Squamous Cell Carcinomas ◽  
Attractive Potential ◽  
Invasion And Metastasis ◽  
Potential Therapeutic Target ◽  
Convergence Point ◽  
Main Components

Head and neck squamous cell carcinomas (HNSCC) are among the most common and lethal tumors worldwide, occurring mostly in oral cavity, pharynx, and larynx tissues. The squamous epithelia homeostasis is supported by the extracellular matrix (ECM), and alterations in this compartment are crucial for cancer development and progression. Laminin is a fundamental component of ECM, where it represents one of the main components of basement membrane (BM), and data supporting its contribution to HNSCC genesis and progression has been vastly explored in oral cavity squamous cell carcinoma. Laminin subtypes 111 (LN-111) and 332 (LN-332) are the main isoforms associated with malignant transformation, contributing to proliferation, adhesion, migration, invasion, and metastasis, due to its involvement in the regulation of several pathways associated with HNSCC carcinogenesis, including the activation of the EGFR/MAPK signaling pathway. Therefore, it draws attention to the possibility that laminin may represent a convergence point in HNSCC natural history, and an attractive potential therapeutic target for these tumors.

scholarly journals N1-Methyladenosine (m1A) Regulator-Mediated Methylation Modification Modes and Tumor Microenvironment Infiltration Characteristics in Head and Neck Squamous Cell Carcinomas

2021 ◽  
Author(s):  
Yan-Dong Miao ◽  
Lin-Jie Mu ◽  
Xiao-Long Tang ◽  
Jiang-Tao Wang ◽  
Jing-Jing Wu ◽  
...  
Keyword(s):  
Overall Survival ◽  
Tumor Microenvironment ◽  
Head And Neck ◽  
Squamous Cell ◽  
Immune Regulation ◽  
Prognostic Indicator ◽  
Squamous Cell Carcinomas ◽  
Poor Overall Survival ◽  
Tumor Mutation Burden ◽  
Mutation Burden

Background: Recent researches have investigated the biological importance of RNA N1-methyladenosine (m1A) modifications in oncogenesis and progression of head and neck squamous cell carcinoma (HNSCC). However, whether m1A modifications also have latent effect in tumor microenvironment (TME) generation and immune regulation in HNSCC is unknown. Methods: We evaluated the m1A modification patterns and related to these modification patterns with TME cell infiltration features in 1041 HNSCC samples by bioinformatics approach. Results: The m1A score is an independent prognostic indicator. HNSCC patients with low m1A score group with poor overall survival (OS) was mainly characterized by stroma activation, lack of sufficient immune infiltration, and exhibited an immune- desert TME phenotype. Low m1A scores were also correlated with increased tumor mutation burden (TMB), and HNSCC patients with high TMB and low m1A scores had the worst OS. In addition, anti-CTLA-4 combined with anti-PD1 treatment was more effective in the high m1A score subgroup than in the low m1A score subgroup. Conclusions: This study revealed that m1A modifications play a non-negligible role in developing the TME versatility and complexity of HNSCC. Assessing m1A modification patterns in HNSCC helps improve our comprehension of its TME infiltration profile and guides more effective immunotherapeutic approaches.

Tumor microenvironment in head and neck squamous cell carcinomas: Predictive value and clinical relevance of hypoxic markers. A review

Head & Neck ◽  
2007 ◽  
Vol 29 (6) ◽  
pp. 591-604 ◽  
Author(s):  
Ilse J. Hoogsteen ◽  
Henri A. M. Marres ◽  
Johan Bussink ◽  
Albert J. van der Kogel ◽  
Johannes H. A. M. Kaanders
Keyword(s):  
Tumor Microenvironment ◽  
Head And Neck ◽  
Squamous Cell ◽  
Predictive Value ◽  
Clinical Relevance ◽  
Squamous Cell Carcinomas

Smoking correlates with the presence of p53 mutations in squamous cell carcinomas of the head and neck (SCCHN)

1998 ◽  
Vol 23 (3) ◽  
pp. 268-269
Author(s):  
Liloglou ◽  
Scholes ◽  
Spandidos ◽  
Jones ◽  
Vaughan ◽  
...  
Keyword(s):  
Head And Neck ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
P53 Mutations

Identification of the Genomic Structure of Tumor Suppressor ING1 and Mutation Analysis in Head and Neck Squamous Cell Carcinomas

2005 ◽  
Vol 14 (2) ◽  
pp. 320-321
Author(s):  
Mehmet Gunduz ◽  
Esra Gunduz ◽  
Byung-Moo Min ◽  
Gene Lee ◽  
Ji-Jun Lim ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Head And Neck ◽  
Mutation Analysis ◽  
Squamous Cell ◽  
Genomic Structure ◽  
Squamous Cell Carcinomas

O53. Multicenter validation of a lymph node metastasis gene expression signature for head and neck squamous cell carcinomas

Oral Oncology ◽  
2011 ◽  
Vol 47 ◽  
pp. S46
Author(s):  
F.K.J. Leusink ◽  
P.J. Slootweg ◽  
M.W.M. van den Brekel ◽  
R.J. Baatenburg de Jong ◽  
F.C.P. Holstege ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Head And Neck ◽  
Squamous Cell ◽  
Gene Expression Signature ◽  
Squamous Cell Carcinomas ◽  
Expression Signature ◽  
Node Metastasis ◽  
Multicenter Validation

Long-Term Follow-up on an Intensified Treatment Regimen for Advanced Resectable Head and Neck Squamous Cell Carcinomas

2001 ◽  
Vol 19 (2) ◽  
pp. 127-136 ◽  
Author(s):  
John C. Grecula ◽  
David E. Schuller ◽  
Roy Smith ◽  
Chris A. Rhoades ◽  
Subir Nag ◽  
...  
Keyword(s):  
Head And Neck ◽  
Treatment Regimen ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Long Term Follow Up
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