scholarly journals High serum CCL20 is associated with tumor progression in penile cancer

2020 ◽  
Vol 11 (23) ◽  
pp. 6812-6822
Author(s):  
Miao Mo ◽  
Shiyu Tong ◽  
Wei Huang ◽  
Yi Cai ◽  
Xiongbing Zu ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Penile Cancer ◽  
High Serum

scholarly journals Serum CXCL13 Level is Associated with Tumor Progression and Unfavorable Prognosis in Penile Cancer

2020 ◽  
Vol Volume 13 ◽  
pp. 8757-8769
Author(s):  
Miao Mo ◽  
Shiyu Tong ◽  
Tao Li ◽  
Xiongbing Zu ◽  
Xiheng Hu
Keyword(s):  
Tumor Progression ◽  
Penile Cancer ◽  
Cxcl13 Level

scholarly journals Serum miR-373-3p and miR-194-5p Are Associated with Early Tumor Progression during FOLFIRINOX Treatment in Pancreatic Cancer Patients: A Prospective Multicenter Study

2021 ◽  
Vol 22 (20) ◽  
pp. 10902
Author(s):  
Fleur van der Sijde ◽  
Marjolein Y. V. Homs ◽  
Marlies L. van Bekkum ◽  
Thierry P. P. van den Bosch ◽  
Koop Bosscha ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Mirna Expression ◽  
Progressive Disease ◽  
High Serum ◽  
Disease Stage ◽  
Ductal Adenocarcinoma ◽  
Chemotherapy Response ◽  
Total N ◽  
Serum Microrna ◽  
Early Tumor

In this study, we explored the predictive value of serum microRNA (miRNA) expression for early tumor progression during FOLFIRINOX chemotherapy and its association with overall survival (OS) in patients with pancreatic ductal adenocarcinoma (PDAC). A total of 132 PDAC patients of all disease stages were included in this study, of whom 25% showed progressive disease during FOLFIRINOX according to the RECIST criteria. MiRNA expression was analyzed in serum collected before the start and after one cycle of chemotherapy. In the discovery cohort (n = 12), a 352-miRNA RT-qPCR panel was used. In the validation cohorts (total n = 120), miRNA expression was detected using individual RT-qPCR miRNA primers. Before the start of FOLFIRINOX, serum miR-373-3p expression was higher in patients with progressive disease compared to patients with disease control after FOLFIRINOX (Log2 fold difference (FD) 0.88, p = 0.006). MiR-194-5p expression after one cycle of FOLFIRINOX was lower in patients with progressive disease (Log2 FD −0.29, p = 0.044). Both miRNAs were predictors of early tumor progression in a multivariable model including disease stage and baseline CA19-9 level (miR-373-3p odds ratio (OR) 3.99, 95% CI 1.10–14.49; miR-194-5p OR 0.91, 95% CI 0.83–0.99). MiR-373-3p and miR-194-5p did not show an association with OS after adjustment for disease stage, baseline CA19-9, and chemotherapy response. In conclusion, high serum miR-373-3p before the start and low serum miR-194-5p after one cycle are associated with early tumor progression during FOLFIRINOX.

scholarly journals High serum haptoglobin level is associated with tumor progression and predicts poor prognosis in non-small cell lung cancer

Oncotarget ◽  
2016 ◽  
Vol 7 (27) ◽  
pp. 41758-41766 ◽  
Author(s):  
Jianjun Lu ◽  
Yanhong Wang ◽  
Miansheng Yan ◽  
Pinning Feng ◽  
Linjing Yuan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Tumor Progression ◽  
Cell Lung Cancer ◽  
Poor Prognosis ◽  
High Serum ◽  
Small Cell ◽  
Small Cell Lung ◽  
Serum Haptoglobin ◽  
Haptoglobin Level

scholarly journals Impact of Fetuin-A (AHSG) on Tumor Progression and Type 2 Diabetes

2018 ◽  
Vol 19 (8) ◽  
pp. 2211 ◽  
Author(s):  
Josiah Ochieng ◽  
Gladys Nangami ◽  
Amos Sakwe ◽  
Cierra Moye ◽  
Joel Alvarez ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Tumor Progression ◽  
Tumor Cells ◽  
Protein Product ◽  
High Serum ◽  
Ectopic Calcification ◽  
Fetuin A ◽  
Multifunctional Protein ◽  
Pathophysiological Role

Fetuin-A is the protein product of the AHSG gene in humans. It is mainly synthesized by the liver in adult humans and is secreted into the blood where its concentration can vary from a low of ~0.2 mg/mL to a high of ~0.8 mg/mL. Presently, it is considered to be a multifunctional protein that plays important roles in diabetes, kidney disease, and cancer, as well as in inhibition of ectopic calcification. In this review we have focused on work that has been done regarding its potential role(s) in tumor progression and sequelae of diabetes. Recently a number of laboratories have demonstrated that a subset of tumor cells such as pancreatic, prostate and glioblastoma multiform synthesize ectopic fetuin-A, which drives their progression. Fetuin-A that is synthesized, modified, and secreted by tumor cells may be more relevant in understanding the pathophysiological role of this enigmatic protein in tumors, as opposed to the relatively high serum concentrations of the liver derived protein. Lastly, auto-antibodies to fetuin-A frequently appear in the sera of tumor patients that could be useful as biomarkers for early diagnosis. In diabetes, solid experimental evidence shows that fetuin-A binds the β-subunit of the insulin receptor to attenuate insulin signaling, thereby contributing to insulin resistance in type 2 diabetes mellitus (T2DM). Fetuin-A also may, together with free fatty acids, induce apoptotic signals in the beta islets cells of the pancreas, reducing the secretion of insulin and further exacerbating T2DM.

scholarly journals Serum CXCL5 level is associated with tumor progression in penile cancer

2021 ◽  
Vol 41 (1) ◽  
Author(s):  
Miao Mo ◽  
Yangle Li ◽  
Xiheng Hu
Keyword(s):  
Tumor Progression ◽  
Cell Lines ◽  
Penile Cancer ◽  
Cox Regression ◽  
Tumor Resection ◽  
Disease Free Survival ◽  
Cancer Biomarker ◽  
Migration And Invasion ◽  
Cox Regression Analysis ◽  
Preoperative Serum

Abstract Chemokine (C-X-C motif) ligand 5 is an important regulator of tumor progression in many cancers, and could serve as potential serum cancer biomarker. Our initial analysis identified CXCL5 as a cancer-related gene highly expressed in PC. Patients with PC exhibited markedly higher preoperative serum CXCL5 levels compared with that in healthy individuals (P<0.001). The area under the curve (AUC) was 0.880 with the sensitivity of 84.0%, and specificity of 80.4% to distinguish PC. Serum CXCL5 levels were also significantly decreased following tumor resection in patients with PC (P=0.001). Preoperative serum CXCL5 level was significantly associated with clinicopathological characteristics including T stage (P=0.001), nodal status (P<0.001), and pelvic lymph node metastasis (P=0.018). Cox regression analysis showed that serum CXCL5 level could serve as an independent prognostic factor for disease-free survival with a HR of 6.363 (95% CI: 2.185–18.531, P=0.001). CXCL5 and its receptor CXCR2 exhibited correlated expression pattern in PC tissues. Differential CXCL5 expression was observed in normal penile tissues, PC cell lines, and their culture supernatants. Furthermore, knockdown of CXCL5 or CXCR2 expression markedly suppressed malignant phenotypes (cell proliferation, clonogenesis, apoptosis escape, migration, and invasion), attenuated STAT3 and AKT signaling, and reduced MMP2/9 secretion in PC cell lines. In conclusion, our findings revealed that serum CXCL5 level might serve as a potential diagnostic and prognostic cancer biomarker for penile cancer. Autocrine CXCL5/CXCR2 signaling might activate multiple downstream oncogenic signaling pathways (STAT3, AKT, MMP2/9) to promote malignant progression of PC, which may warrant further investigation in the future.

Fibronexus-Like Adhesion Sites are Present at the Invasive Zones of Human Epidermoid Carcinomas

1982 ◽  
Vol 40 ◽  
pp. 106-109
Author(s):  
Irwin I. Singer
Keyword(s):  
Cell Cycle ◽  
Serum Concentration ◽  
Substrate Binding ◽  
High Serum ◽  
Adhesion Sites ◽  
Substrate Adhesion ◽  
Focal Contacts ◽  
Adhesion Complex ◽  
Low Serum

Our previous results indicate that two types of fibronectin-cytoskeletal associations may be formed at the fibroblast surface: dorsal matrixbinding fibronexuses generated in high serum (5% FBS) cultures, and ventral substrate-adhering units formed in low serum (0.3% FBS) cultures. The substrate-adhering fibronexus consists of at least vinculin (VN) and actin in its cytoplasmic leg, and fibronectin (FN) as one of its major extracellular components. This substrate-adhesion complex is localized in focal contacts, the sites of closest substratum approach visualized with interference reflection microscopy, which appear to be the major points of cell-tosubstrate adhesion. In fibroblasts, the latter substrate-binding complex is characteristic of cultures that are arrested at the G1 phase of the cell cycle due to the low serum concentration in their medium. These arrested fibroblasts are very well spread, flattened, and immobile.

Expressions of cyclooxygenase-2 (COX-2) and prostaglandin E receptors (EPs) in gallbladder carcinoma (GBca)-association with tumor progression

2001 ◽  
Vol 120 (5) ◽  
pp. A573-A573
Author(s):  
J SHODA ◽  
T ASANO ◽  
T KAWAMOTO ◽  
Y MATSUZAKI ◽  
N TANAKA ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Gallbladder Carcinoma ◽  
Cyclooxygenase 2 ◽  
Prostaglandin E ◽  
Cox 2

150: Inhibition of Tumor Progression Using Antisense Oligonucleotide Targeting GLI2 in Androgen Independent Prostate Cancer

2007 ◽  
Vol 177 (4S) ◽  
pp. 51-51
Author(s):  
Shintaro Narita ◽  
Alan I. So ◽  
Shannon Sinnemann ◽  
Ladan Fazli ◽  
Eric G. Marcusson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Progression ◽  
Antisense Oligonucleotide ◽  
Androgen Independent

1315: Total Phallic Reconstruction in Management of Penile Cancer: Experience in 10 Patients from a Single Centre

2006 ◽  
Vol 175 (4S) ◽  
pp. 423-423
Author(s):  
David J. Ralph ◽  
Vineet Agarwal ◽  
Suks Minhas ◽  
Nim Christopher
Keyword(s):  
Penile Cancer ◽  
Single Centre ◽  
Cancer Experience
Sign in / Sign up

Export Citation Format

Share Document