scholarly journals A Pilot Study Assessing the Potential Role of non-CD133 Colorectal Cancer Stem Cells as Biomarkers

2012 ◽  
Vol 3 ◽  
pp. 231-240 ◽  
Author(s):  
Russell C. Langan ◽  
John E. Mullinax ◽  
Satyajit Ray ◽  
Manish T. Raiji ◽  
Nicholas Schaub ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Pilot Study ◽  
Cancer Stem Cells ◽  
Potential Role ◽  
Colorectal Cancer Stem Cells

Abstract 1083: A novel role of SRC in mediating bypass resistance to MEK inhibition in colorectal cancer stem cells

2021 ◽  
Author(s):  
Mingli Yang ◽  
Thomas B. Davis B. Davis ◽  
Michael V. Nebozhyn ◽  
Andrey Loboda ◽  
Heiman Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Mek Inhibition ◽  
Colorectal Cancer Stem Cells

Dietary Choices Modulate Colorectal Cancer Stem Cells: A Role of FXR Nuclear Receptor

2020 ◽  
pp. 1-8
Author(s):  
Nilesh Kumar Sharma ◽  
Sachin C. Sarode ◽  
Gargi S Sarode ◽  
Shankargouda Patil ◽  
Jayanta K. Pal
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Nuclear Receptor ◽  
Dietary Choices ◽  
Colorectal Cancer Stem Cells

scholarly journals Colorectal Cancer Biomarkers and the Potential Role of Cancer Stem Cells

2013 ◽  
Vol 4 (3) ◽  
pp. 241-250 ◽  
Author(s):  
Russell C. Langan ◽  
John E. Mullinax ◽  
Manish T. Raiji ◽  
Trevor Upham ◽  
Thomas Summers ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Potential Role ◽  
Cancer Biomarkers

scholarly journals The Role of Colorectal Cancer Stem Cells in Metastatic Disease and Therapeutic Response

Cancers ◽  
2011 ◽  
Vol 3 (1) ◽  
pp. 319-339 ◽  
Author(s):  
Eric C. Anderson ◽  
Crystal Hessman ◽  
Trevor G. Levin ◽  
Marcus M. Monroe ◽  
Melissa H. Wong
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Metastatic Disease ◽  
Therapeutic Response ◽  
Colorectal Cancer Stem Cells

Abstract 1716: The role of CD44v9+ colorectal cancer stem cells in the resistance to cetuximab treatment

2016 ◽  
Author(s):  
Chia-Nung Hung ◽  
Ching-Yu Chang ◽  
Jou Hsiao ◽  
Wan-Chen Wei ◽  
Wei-Ting Chao
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Colorectal Cancer Stem Cells

A pilot study evaluating the safety and impact of pretreatment with metformin on colorectal cancer stem cells (CCSC) in patients undergoing resection.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. e14581-e14581 ◽  
Author(s):  
Nicholas C. DeVito ◽  
Martin D. Goodman ◽  
Jennifer Caplain ◽  
Shrikar Rajagopal ◽  
Daniel Popowich ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Pilot Study ◽  
Cancer Stem Cells ◽  
Colorectal Cancer Stem Cells

scholarly journals The microRNA-210-Stathmin1 Axis Decreases Cell Stiffness to Facilitate the Invasiveness of Colorectal Cancer Stem Cells

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1833
Author(s):  
Tsai-Tsen Liao ◽  
Wei-Chung Cheng ◽  
Chih-Yung Yang ◽  
Yin-Quan Chen ◽  
Shu-Han Su ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cell Motility ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Cell Stiffness ◽  
Mesenchymal Transition ◽  
Cytoskeletal Dynamics ◽  
Colorectal Cancer Stem Cells

Cell migration is critical for regional dissemination and distal metastasis of cancer cells, which remain the major causes of poor prognosis and death in patients with colorectal cancer (CRC). Although cytoskeletal dynamics and cellular deformability contribute to the migration of cancer cells and metastasis, the mechanisms governing the migratory ability of cancer stem cells (CSCs), a nongenetic source of tumor heterogeneity, are unclear. Here, we expanded colorectal CSCs (CRCSCs) as colonospheres and showed that CRCSCs exhibited higher cell motility in transwell migration assays and 3D invasion assays and greater deformability in particle tracking microrheology than did their parental CRC cells. Mechanistically, in CRCSCs, microRNA-210-3p (miR-210) targeted stathmin1 (STMN1), which is known for inducing microtubule destabilization, to decrease cell elasticity in order to facilitate cell motility without affecting the epithelial–mesenchymal transition (EMT) status. Clinically, the miR-210-STMN1 axis was activated in CRC patients with liver metastasis and correlated with a worse clinical outcome. This study elucidates a miRNA-oriented mechanism regulating the deformability of CRCSCs beyond the EMT process.

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