scholarly journals Lysophosphatidic Acid Receptors: Biochemical and Clinical Implications in Different Diseases

2020 ◽  
Vol 11 (12) ◽  
pp. 3519-3535 ◽  
Author(s):  
Hongjiao Xiang ◽  
Yifei Lu ◽  
Mingmei Shao ◽  
Tao Wu
Keyword(s):  
Lysophosphatidic Acid ◽  
Clinical Implications ◽  
Lysophosphatidic Acid Receptors

Systemic blockade of LPA1/3 lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior

2018 ◽  
Vol 133 ◽  
pp. 189-201 ◽  
Author(s):  
Laura Sánchez-Marín ◽  
David Ladrón de Guevara-Miranda ◽  
M. Carmen Mañas-Padilla ◽  
Francisco Alén ◽  
Román D. Moreno-Fernández ◽  
...  
Keyword(s):  
Lysophosphatidic Acid ◽  
Brain And Behavior ◽  
And Behavior ◽  
The Brain ◽  
Lysophosphatidic Acid Receptors

scholarly journals MicroRNA Regulation of the Autotaxin-Lysophosphatidic Acid Signaling Axis

Cancers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1369 ◽  
Author(s):  
Mandi M. Murph
Keyword(s):  
Lysophosphatidic Acid ◽  
Current Status ◽  
Mirna Regulation ◽  
Exciting Field ◽  
Microrna Regulation ◽  
Normal Tissues ◽  
Argonaute Proteins ◽  
Signaling Axis ◽  
Lysophosphatidic Acid Signaling ◽  
Lysophosphatidic Acid Receptors

The revelation that microRNAs (miRNAs) exist within the human genome uncovered an underappreciated mechanism of gene expression. For cells to regulate expression of their genes, miRNA molecules and argonaute proteins bind to mRNAs and interfere with efficient translation of the RNA transcript. Although miRNAs have important roles in normal tissues, miRNAs may adopt aberrant functions in malignant cells depending on their classification as either a tumor suppressor or oncogenic miRNA. Within this review, the current status of miRNA regulation is described in the context of signaling through the lysophosphatidic acid receptors, including the lysophosphatidic acid-producing enzyme, autotaxin. Thus far, research has revealed miRNAs that increase in response to lysophosphatidic acid stimulation, such as miR-21, miR-30c-2-3p, and miR-122. Other miRNAs inhibit the translation of lysophosphatidic acid receptors, such as miR-15b, miR-23a, and miR200c, or proteins that are downstream of lysophosphatidic acid signaling, such as miR-146 and miR-21. With thousands of miRNAs still uncharacterized, it is anticipated that the complex regulation of lysophosphatidic acid signaling by miRNAs will continue to be elucidated. RNA-based therapeutics have entered the clinic with enormous potential in precision medicine. This exciting field is rapidly emerging and it will be fascinating to witness its expansion in scope.

scholarly journals Identification of Residues Responsible for Ligand Recognition and Regioisomeric Selectivity of Lysophosphatidic Acid Receptors Expressed in Mammalian Cells

2005 ◽  
Vol 280 (41) ◽  
pp. 35038-35050 ◽  
Author(s):  
Yuko Fujiwara ◽  
Vineet Sardar ◽  
Akira Tokumura ◽  
Daniel Baker ◽  
Kimiko Murakami-Murofushi ◽  
...  
Keyword(s):  
Lysophosphatidic Acid ◽  
Mammalian Cells ◽  
Ligand Recognition ◽  
Lysophosphatidic Acid Receptors

scholarly journals Lysophosphatidic Acid Receptors Determine Tumorigenicity and Aggressiveness of Ovarian Cancer Cells

2008 ◽  
Vol 100 (22) ◽  
pp. 1630-1642 ◽  
Author(s):  
Shuangxing Yu ◽  
Mandi M. Murph ◽  
Yiling Lu ◽  
Shuying Liu ◽  
Hassan S. Hall ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Lysophosphatidic Acid ◽  
Ovarian Cancer Cells ◽  
Lysophosphatidic Acid Receptors
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