scholarly journals PNCK depletion inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells in vitro and in vivo

2019 ◽  
Vol 10 (27) ◽  
pp. 6925-6932 ◽  
Author(s):  
Yuanji Xu ◽  
Jiling Wang ◽  
Shaoli Cai ◽  
Guanghao Chen ◽  
Nanyang Xiao ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Carcinoma Cells ◽  
Human Nasopharyngeal Carcinoma

Chk1 inhibitor Gö6976 enhances the sensitivity of nasopharyngeal carcinoma cells to radiotherapy and chemotherapy in vitro and in vivo

2010 ◽  
Vol 297 (2) ◽  
pp. 190-197 ◽  
Author(s):  
Zizhen Feng ◽  
Shuangbing Xu ◽  
Mengzhong Liu ◽  
Yi-Xin Zeng ◽  
Tiebang Kang
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Carcinoma Cells ◽  
Chk1 Inhibitor

scholarly journals RASSF1A inhibits PDGFB-driven malignant phenotypes of nasopharyngeal carcinoma cells in a YAP1-dependent manner

2020 ◽  
Vol 11 (10) ◽  
Author(s):  
Ying-Ying Liang ◽  
Xu-Bin Deng ◽  
Xian-Tao Lin ◽  
Li-Li Jiang ◽  
Xiao-Ting Huang ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Underlying Mechanism ◽  
Carcinoma Cells ◽  
Dependent Manner ◽  
Transcriptional Coactivator ◽  
Actin Remodeling ◽  
Aggressive Tumor ◽  
Subunit B

Abstract Nasopharyngeal carcinoma (NPC) is a highly aggressive tumor characterized by distant metastasis. Deletion or down-regulation of the tumor suppressor protein ras-association domain family protein1 isoform A (RASSF1A) has been confirmed to be a key event in NPC progression; however, little is known about the effects or underlying mechanism of RASSF1A on the malignant phenotype. In the present study, we observed that RASSF1A expression inhibited the malignant phenotypes of NPC cells. Stable silencing of RASSF1A in NPC cell lines induced self-renewal properties and tumorigenicity in vivo/in vitro and the acquisition of an invasive phenotype in vitro. Mechanistically, RASSF1A inactivated Yes-associated Protein 1 (YAP1), a transcriptional coactivator, through actin remodeling, which further contributed to Platelet Derived Growth Factor Subunit B (PDGFB) transcription inhibition. Treatment with ectopic PDGFB partially increased the malignancy of NPC cells with transient knockdown of YAP1. Collectively, these findings suggest that RASSF1A inhibits malignant phenotypes by repressing PDGFB expression in a YAP1-dependent manner. PDGFB may serve as a potential interest of therapeutic regulators in patients with metastatic NPC.

scholarly journals Osthole sensitizes with radiotherapy to suppress tumorigenesis of human nasopharyngeal carcinoma in vitro and in vivo

2018 ◽  
Vol Volume 10 ◽  
pp. 5471-5477 ◽  
Author(s):  
Lin Peng ◽  
Yi-Teng Huang ◽  
Jian Chen ◽  
Yi-Xuan Zhuang ◽  
Fan Zhang ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Human Nasopharyngeal Carcinoma

COMPARISON OF AMINOLEVULINIC ACID AND ITS METHYL ESTER MEDIATED PHOTOCYTOTOXICITY ON HUMAN NASOPHARYNGEAL CARCINOMA CELLS

2012 ◽  
Vol 05 (02) ◽  
pp. 1250007 ◽  
Author(s):  
CHRISTINE M. N. YOW ◽  
RICKY W. K. WU ◽  
ZHENG HUANG
Keyword(s):  
Photodynamic Therapy ◽  
Methyl Ester ◽  
Nasopharyngeal Carcinoma ◽  
Small Molecule ◽  
Aminolevulinic Acid ◽  
Carcinoma Cells ◽  
Southern Asia ◽  
Human Nasopharyngeal Carcinoma

Nasopharyngeal carcinoma (NPC) is a prevalent cancer in some areas of southern Asia. To explore the potential of photodynamic therapy (PDT) for the treatment of NPC, a small molecule prodrug 5-aminolevulinic acid (ALA) and its methyl ester (MAL) mediated PDT was studied in vitro. The results showed that human NPC cells were sensitive to both ALA- and MAL-mediated PDT. However, ALA was more effective than MAL, possiblly due to a higher efficiency of ALA on producing endogenous protoporphyrin (PpIX) in NPC cells. Neither ALA nor MAL caused any significant genotoxicity. The ALA-based PDT might be a useful modality in the treatment of NPC.

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