scholarly journals Prognostic role of pretreatment red blood cell distribution width in patients with cancer: A meta-analysis of 49 studies

2019 ◽  
Vol 10 (18) ◽  
pp. 4305-4317 ◽  
Author(s):  
Peng-Fei Wang ◽  
Si-Ying Song ◽  
Hang Guo ◽  
Ting-Jian Wang ◽  
Ning Liu ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Meta Analysis ◽  
Cell Distribution ◽  
Prognostic Role ◽  
Distribution Width ◽  
Patients With Cancer ◽  
Red Blood Cell Distribution

scholarly journals Prognostic Role of the Red Blood Cell Distribution Width (RDW) in Hodgkin Lymphoma

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3262
Author(s):  
Ines Herraez ◽  
Leyre Bento ◽  
Raquel Del Campo ◽  
Adriana Sas ◽  
Rafael Ramos ◽  
...  
Keyword(s):  
Blood Cell ◽  
Hodgkin Lymphoma ◽  
Red Blood Cell ◽  
Prognostic Scores ◽  
Cell Distribution ◽  
Secondary Malignancies ◽  
Prognostic Role ◽  
Distribution Width ◽  
Red Blood Cell Distribution

The red blood cell distribution width (RDW) is a parameter available from an automated blood count, which measures the degree of heterogeneity of erythrocyte volume and increases in inflammatory conditions. The prognostic role of RDW has been described in different types of cancers. Hodgkin lymphoma (HL) is a hematological malignancy, known to have a proinflammatory background. We aim to study the prognostic role of RDW in HL. We retrospectively analyzed 264 patients with HL from two hospitals in the Balearic Islands between 1990 and 2018. Higher levels of RDW were independently related to anemia, B-symptoms, and low albumin. In age ≥45 years, the presence of lymphopenia and higher RDW were independently associated with worse event-free survival (EFS) and overall survival (OS). Long-term incidence of secondary malignancies was significantly higher in patients with higher RDW, particularly lung cancer. In conclusion, we report for the first time that RDW is a simple, cheap, and easily available prognostic factor in HL that identifies a group with worse EFS, OS, and a higher potential incidence of secondary malignancies. RDW seems to be related to most adverse prognostic factors in HL, making RDW an excellent candidate to be included in prognostic scores for HL.

The prognostic role of red blood cell distribution width in transfused and non-transfused critically ill patients

2019 ◽  
Vol 85 (11) ◽  
Author(s):  
Alberto Fogagnolo ◽  
Savino Spadaro ◽  
Fabio S. Taccone ◽  
Riccardo Ragazzi ◽  
Anna Romanello ◽  
...  
Keyword(s):  
Blood Cell ◽  
Critically Ill ◽  
Red Blood Cell ◽  
Critically Ill Patients ◽  
Cell Distribution ◽  
Prognostic Role ◽  
Distribution Width ◽  
Red Blood Cell Distribution

scholarly journals Red Blood Cell Distribution Width, Disease Severity, and Mortality in Hospitalized Patients with SARS-CoV-2 Infection: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 10 (2) ◽  
pp. 286
Author(s):  
Angelo Zinellu ◽  
Arduino A. Mangoni
Keyword(s):  
Systematic Review ◽  
Blood Cell ◽  
Disease Severity ◽  
Red Blood Cell ◽  
Effect Size ◽  
Meta Analysis ◽  
Severe Illness ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution

The identification of biomarkers predicting disease severity and outcomes is the focus of intense research in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 infection). Ideally, such biomarkers should be easily derivable from routine tests. We conducted a systematic review and meta-analysis of the predictive role of the red blood cell distribution width (RDW), a routine hematological test, in patients with SARS-CoV-2 infection. We searched the electronic databases PubMed, Web of Science and Scopus, from January 2020 to November 2020, for studies reporting data on the RDW and coronavirus disease 2019 (COVID-19) severity, defined as severe illness or admission to the intensive care unit (ICU), and mortality. Eleven studies in 4901 COVID-19 patients were selected for the meta-analysis. Pooled results showed that the RDW values were significantly higher in patients with severe disease and non-survivors (standard mean difference, SMD = 0.56, 95% CI 0.31 to 0.81, p < 0.001). Heterogeneity between studies was extreme (I2 = 80.6%; p < 0.001). In sensitivity analysis, the effect size was not modified when each study was in turn removed (effect size range, between 0.47 and 0.63). The Begg’s (p = 0.53) and Egger’s tests (p = 0.52) showed no evidence of publication bias. No significant correlations were observed between SMD and age, gender, whole blood count, end point, study geographic area, or design. Our meta-analysis showed that higher RDW values are significantly associated with COVID-19 severity and mortality. This routine parameter might assist with early risk stratification in patients with SARS-CoV-2 infection.

scholarly journals Association between red blood cell distribution width and mortality and severity among patients with COVID‐19: A systematic review and meta‐analysis

2021 ◽  
Vol 93 (4) ◽  
pp. 2513-2522
Author(s):  
Jane J. Lee ◽  
Sahar M. Montazerin ◽  
Adeel Jamil ◽  
Umer Jamil ◽  
Jolanta Marszalek ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Meta Analysis ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution
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