scholarly journals The long noncoding RNA KCNQ1DN suppresses the survival of renal cell carcinoma cells through downregulating c-Myc

2019 ◽  
Vol 10 (19) ◽  
pp. 4662-4670
Author(s):  
Fan Yang ◽  
Qingjian Wu ◽  
Le Zhang ◽  
Wei Xie ◽  
Xiaoli Sun ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Long Noncoding Rna ◽  
Renal Cell ◽  
Noncoding Rna ◽  
Carcinoma Cells

scholarly journals Downregulation of long noncoding RNA FENDRR predicts poor prognosis in renal cell carcinoma

2018 ◽  
Author(s):  
Wang He ◽  
Guangzheng Zhong ◽  
Pei Wang ◽  
Chun Jiang ◽  
Ning Jiang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Long Noncoding Rna ◽  
Renal Cell ◽  
Noncoding Rna ◽  
Poor Prognosis

scholarly journals Genetic variants in a long noncoding RNA related to Sunitinib Resistance predict risk and survival of patients with renal cell carcinoma

2019 ◽  
Vol 8 (6) ◽  
pp. 2886-2896 ◽  
Author(s):  
Qianwei Xing ◽  
Ran Li ◽  
Aiming Xu ◽  
Zhiqiang Qin ◽  
Jinyuan Tang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Genetic Variants ◽  
Long Noncoding Rna ◽  
Renal Cell ◽  
Noncoding Rna

scholarly journals Long Noncoding RNA MALAT1 Promotes Aggressive Renal Cell Carcinoma through Ezh2 and Interacts with miR-205

2015 ◽  
Vol 75 (7) ◽  
pp. 1322-1331 ◽  
Author(s):  
Hiroshi Hirata ◽  
Yuji Hinoda ◽  
Varahram Shahryari ◽  
Guoren Deng ◽  
Koichi Nakajima ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Long Noncoding Rna ◽  
Renal Cell ◽  
Noncoding Rna

scholarly journals Long Noncoding RNA LINC01133 Promotes the Malignant Behaviors of Renal Cell Carcinoma by Regulating the miR-30b-5p/Rab3D Axis

2020 ◽  
Vol 29 ◽  
pp. 096368972096441
Author(s):  
Xiaoqiang Zhai ◽  
Yan Wu ◽  
Zhenlong Wang ◽  
Dawei Zhao ◽  
Hecheng li ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Lines ◽  
Long Noncoding Rna ◽  
Renal Cell ◽  
Noncoding Rna ◽  
Polymerase Chain Reaction Analysis ◽  
Migration And Invasion ◽  
Tissue Specimens

Renal cell carcinoma (RCC) is the most common type of kidney cancer with rising incidence. Long noncoding RNA (lncRNA) LINC01133 is a novel lncRNA that is involved in the development of several types of cancers. However, the role of LINC01133 in RCC has not been reported. Thus, in this study, we investigated the functions of LINC01133 in RCC. The qualitative real-time polymerase chain reaction analysis was performed to examine the levels of LINC01133 in RCC tissues and adjacent tissues, as well as RCC cell lines. The results showed that LINC01133 was highly expressed in RCC tissue specimens and cell lines. Downregulation of LINC01133 significantly inhibited the proliferation, migration, and invasion of RCC cells. Further mechanistic investigations proved that LINC01133 directly interacted with microRNA (miR)-30b-5p and regulated the miR-30b-5p expression in RCC cell lines. Moreover, miR-30b-5p exhibited tumor-suppressive activity in RCC cell lines, which was mediated by targeting Ras-related protein Rab-3D (Rab3D). In vivo study showed that LINC01133 knockdown suppressed tumor growth in the nude mice. Taken together, these findings indicated that LINC01133 might be an oncogene in RCC through regulation of the miR-30b-5p/Rab3D axis. Thus, LINC01133 might serve as a potential therapeutic target for the treatment of RCC.

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