scholarly journals Pathologic and prognostic impacts of FGFR2 amplification in gastric cancer: a meta-analysis and systemic review

2019 ◽  
Vol 10 (11) ◽  
pp. 2560-2567
Author(s):  
Hyeong Su Kim ◽  
Jung Han Kim ◽  
Hyun Joo Jang
Keyword(s):  
Gastric Cancer ◽  
Meta Analysis ◽  
Systemic Review

scholarly journals A systemic review and meta-analysis for prognostic values of pretreatment lymphocyte-to-monocyte ratio on gastric cancer

2019 ◽  
Vol 17 ◽  
pp. 205873921983109
Author(s):  
Zhigui Li ◽  
Zhaofen Xu ◽  
Yuqian Huang ◽  
Yong Wang ◽  
Hare Ram Karn ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Clinical Outcomes ◽  
Cancer Progression ◽  
Meta Analysis ◽  
Prognostic Significance ◽  
Young Patients ◽  
Systemic Review ◽  
Cochrane Library ◽  
Low Level ◽  
Lymphocyte To Monocyte Ratio

The systemic inflammation plays a crucial role in carcinogenesis and cancer progression. Pretreatment lymphocyte-to-monocyte ratio (LMR) has been suggested to be associated with clinical outcomes in various malignancies. To evaluate the prognostic significance of pretreatment LMR on gastric cancer, we conducted a comprehensive literature search in PubMed, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov (Prospero Registration No. CRD42018087263). This meta-analysis included all studies evaluating the prognostic significance of pretreatment LMR on gastric cancer. The main outcome measures included overall survival (OS), progression-free survival (PFS), and the relationship between LMR and clinicopathological features. In total, 11 studies (12 cohorts) enrolling 14,262 patients with gastric cancer were included. The pooled estimates showed that elevated pretreatment LMR was significantly associated with better OS (hazard ratio (HR): 0.71, 95% confidence interval (CI): 0.58–0.83) and better PFS (HR: 0.71, 95% CI: 0.44–0.99). The elevated LMR was also significantly associated with young patients, female, low level of carcinoembryonic antigen (CEA), low level of carbohydrate antigen 19-9 (CA19-9), stage I–II, small tumor size, absence of lymph node metastasis, absence of vascular invasion, and absence of perineural invasion. In conclusion, the elevated pretreatment LMR predicted the better clinical outcomes in patients with gastric cancer.

scholarly journals Systemic Review and Meta-analysis of Impact of Splenectomy for Advanced Gastric Cancer

In Vivo ◽  
2020 ◽  
Vol 34 (6) ◽  
pp. 3115-3125
Author(s):  
CHIKARA KUNISAKI ◽  
SHO SATO ◽  
NOBUHIRO TSUCHIYA ◽  
JUN WATANABE ◽  
TSUTOMU SATO ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Advanced Gastric Cancer ◽  
Meta Analysis ◽  
Systemic Review

scholarly journals Partial Versus Total Omentectomy in Patients with Gastric Cancer: A Systemic Review and Meta-Analysis

Cancers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 4971
Author(s):  
Shion Wei Chai ◽  
Suo-Hsien Wang ◽  
Chih-Yuan Wang ◽  
Yi-Chan Chen ◽  
Ruey-Shyang Soong ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Overall Survival ◽  
Meta Analysis ◽  
Disease Free Survival ◽  
Systemic Review ◽  
Cochrane Library ◽  
Free Survival ◽  
Significant Difference ◽  
Hospital Stays ◽  
Disease Free

Background: Surgical treatment is the key to cure localized gastric cancer. There is no strong evidence that supports the value of omentectomy. Thus, a meta-analysis was conducted to compare the safety and efficiency of partial and total omentectomy in patients with gastric cancer. Methods: PubMed, Embase, and Cochrane Library databases were searched. All studies that compared total and partial omentectomy as treatments for gastric cancer were included. The primary outcomes were patients’ overall survival and disease-free survival, while the secondary outcomes were perioperative outcome and postoperative complications. Results: A total of nine studies were examined, wherein 1043 patients were included in the partial omentectomy group, and 1995 in the total omentectomy group. The partial omentectomy group was associated with better overall survival (hazard ratio: 0.80, 95% CI: 0.66 to 0.98, p = 0.04, I2 = 0%), shorter operative time, and lesser blood loss than the total omentectomy group. In addition, no statistically significant difference was observed in the number of dissected lymph nodes, length of hospital stays, complication rate, and disease-free survival. Conclusions: Our results show that, compared with total omentectomy in gastric cancer surgery, partial omentectomy had non-inferior oncological outcomes and comparable safety outcomes.

scholarly journals Cinobufacini Injection Improves the Efficacy of Chemotherapy on Advanced Stage Gastric Cancer: A Systemic Review and Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Xing Zhang ◽  
Yuan Yuan ◽  
Yupeng Xi ◽  
Xinyao Xu ◽  
Qiujun Guo ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Meta Analysis ◽  
Life Quality ◽  
Systemic Review ◽  
High Morbidity ◽  
Increase Response Rate ◽  
Advanced Stage ◽  
Treatment Protocols ◽  
Hand Foot Syndrome ◽  
Cinobufacini Injection

Gastric cancer has a high morbidity and mortality. Chemotherapy regimens are routine advanced stage gastric cancer (AGC) treatment protocols, but most of these drugs have side-effects such as myelosuppression and gastrointestinal disorders. Cinobufacini, an extractive from TCM, could suppress cell proliferation and inhibit gastric cancer. In this study, we comprehensively reviewed the literature on the efficacy comparison between Cinobufacini injection combined with chemotherapy and chemotherapy solely used in AGC treatment. We extracted data for from six electronic databases to evaluate the efficacy of Cinobufacini injection on AGC patients. Twelve studies with a total of 853 patients were finally included in our study. The results indicated that Cinobufacini injection could increase response rate and disease control rate of chemotherapy on AGC, improve the life quality of AGC patients, increase leukocytes, improve anemia, improve hand-foot syndrome induced by chemotherapy, and relieve cancer pain. This study has its own limitations that prevented us from drawing a definite conclusion and more well-designed clinical trials of TCM are needed.

scholarly journals Efficacy and safety of targeting VEGFR drugs in treatment for advanced or metastatic gastric cancer: a systemic review and meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 9 (8) ◽  
pp. 8120-8132
Author(s):  
Duanrui Liu ◽  
Xiaoli Ma ◽  
Dongjie Xiao ◽  
Yanfei Jia ◽  
Yunshan Wang
Keyword(s):  
Gastric Cancer ◽  
Meta Analysis ◽  
Metastatic Gastric Cancer ◽  
Systemic Review ◽  
Efficacy And Safety

scholarly journals Association between Habitual Dietary Salt Intake and Risk of Gastric Cancer: A Systematic Review of Observational Studies

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Sheng Ge ◽  
Xiaohui Feng ◽  
Li Shen ◽  
Zhanying Wei ◽  
Qiankun Zhu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Salt Intake ◽  
Meta Analysis ◽  
Positive Association ◽  
Case Control ◽  
Systemic Review ◽  
Dietary Salt ◽  
Case Control Studies ◽  
Dietary Salt Intake ◽  
High Salt Intake

Purpose.Systematic reviews of case-control and prospective studies showed a positive association between habitual salt intake and gastric cancer. Given new studies published thereafter, we carried out a meta-analysis to assess the association between dietary salt intake and gastric cancer.Methods.Case-control studies and cohort studies published between January 1992 and January 2012 on PubMed and Embase were searched. We quantified associations between salt intake and gastric cancer with meta-analysis.Results.Eleven studies (7 case controls and 4 cohorts) finally were included in the meta-analysis (total population:n=2076498; events:n=12039). The combined odds ratio showed significantly positive association between high salt intake and gastric cancer compared with low salt intake (OR = 2.05, 95% CI [1.60, 2.62];P<0.00001). In subgroup meta-analysis, findings were slightly different when analyses were restricted to salty food intake (OR = 2.41, 95% CI [2.08, 2.78];P<0.00001) as well as in Asia (OR = 1.27 95% CI [1.22, 1.32];P<0.00001). There was no evidence that sample size, exposure assessment substantially influenced the estimate of effects.Conclusions.The systemic review supports the hypothesis that dietary salt intake is positively associated with the risk of gastric cancer.

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