scholarly journals Prognostic Value of PDZ-Binding Kinase/T-LAK Cell-Originated Protein Kinase (PBK/TOPK) in Patients with Cancer

2019 ◽  
Vol 10 (1) ◽  
pp. 131-137 ◽  
Author(s):  
Yi Zhang ◽  
Xianjin Yang ◽  
Rong Wang ◽  
Xu Zhang
Keyword(s):  
Protein Kinase ◽  
Prognostic Value ◽  
Patients With Cancer ◽  
Lak Cell

scholarly journals T-LAK Cell-originated Protein Kinase (TOPK) Phosphorylation of Prx1 at Ser-32 Prevents UVB-induced Apoptosis in RPMI7951 Melanoma Cells through the Regulation of Prx1 Peroxidase Activity

2010 ◽  
Vol 285 (38) ◽  
pp. 29138-29146 ◽  
Author(s):  
Tatyana A. Zykova ◽  
Feng Zhu ◽  
Tatyana I. Vakorina ◽  
Jishuai Zhang ◽  
Lee Ann Higgins ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Peroxidase Activity ◽  
Melanoma Cells ◽  
Lak Cell ◽  
Induced Apoptosis

T-LAK Cell-Originated Protein Kinase (TOPK) as a Prognostic Factor and a Potential Therapeutic Target in Ovarian Cancer

2016 ◽  
Vol 22 (24) ◽  
pp. 6110-6117 ◽  
Author(s):  
Yuji Ikeda ◽  
Jae-Hyun Park ◽  
Takashi Miyamoto ◽  
Naofumi Takamatsu ◽  
Taigo Kato ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Protein Kinase ◽  
Prognostic Factor ◽  
Therapeutic Target ◽  
Potential Therapeutic Target ◽  
Lak Cell

Prognostic value of the G8 and modified-G8 screening tools for multidimensional health problems in older patients with cancer

2017 ◽  
Vol 83 ◽  
pp. 211-219 ◽  
Author(s):  
Claudia Martinez-Tapia ◽  
Elena Paillaud ◽  
Evelyne Liuu ◽  
Christophe Tournigand ◽  
Rima Ibrahim ◽  
...  
Keyword(s):  
Older Patients ◽  
Prognostic Value ◽  
Health Problems ◽  
Screening Tools ◽  
Patients With Cancer ◽  
Multidimensional Health

scholarly journals Baicalin suppresses lung cancer growth by targeting PDZ-binding kinase/T-LAK cell-originated protein kinase

2019 ◽  
Vol 39 (4) ◽  
Author(s):  
Xin Diao ◽  
Danfen Yang ◽  
Yu Chen ◽  
Wentian Liu
Keyword(s):  
Lung Cancer ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Ex Vivo ◽  
Lung Cancer Cells ◽  
Cancer Growth ◽  
Downstream Signaling ◽  
Lak Cell

AbstractBaicalin is the main bioactive component extracted from the traditional Chinese medicine Baical Skullcap Root, and its anti-tumor activity has been studied in previous studies. PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK), a serine/threonine protein kinase, is highly expressed in many cancer cells and stimulates the tumorigenic properties, and so, it is a pivotal target for agent to cure cancers. We reported for the first time that baicalin suppressed PBK/TOPK activities by directly binding with PBK/TOPK in vitro and in vivo. Ex vivo studies showed that baicalin suppressed PBK/TOPK activity in JB6 Cl41 cells and H441 lung cancer cells. Moreover, knockdown of PBK/TOPK in H441 cells decreased their sensitivity to baicalin. In vivo study indicated that injection of baicalin in H441 tumor-bearing mice effectively suppressed cancer growth. The PBK/TOPK downstream signaling molecules Histone H3 and ERK2 in tumor tissues were also decreased after baicalin treatment. Taken together, baicalin can inhibit proliferation of lung cancer cells as a PBK/TOPK inhibitor both in vitro and in vivo.

scholarly journals Prognostic Value of Albumin/Globulin Ratio in Survival and Lymph Node Metastasis in Patients with Cancer: A Systematic Review and Meta-analysis

2018 ◽  
Vol 9 (13) ◽  
pp. 2341-2348 ◽  
Author(s):  
Jieshan Chi ◽  
Qizhi Xie ◽  
Jingjing Jia ◽  
Xiaoma Liu ◽  
Jingjing Sun ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Patients With Cancer ◽  
Node Metastasis

Critical roles of T-LAK cell-originated protein kinase in cytokinesis

2010 ◽  
Vol 101 (2) ◽  
pp. 403-411 ◽  
Author(s):  
Jae-Hyun Park ◽  
Toshihiko Nishidate ◽  
Yusuke Nakamura ◽  
Toyomasa Katagiri
Keyword(s):  
Protein Kinase ◽  
Lak Cell
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