scholarly journals Regulatory sequence analysis of semaphorin 4D 5' non-coding region

2019 ◽  
Vol 10 (4) ◽  
pp. 903-910
Author(s):  
Lijuan Qiu ◽  
Hongchao Jiang ◽  
Jia Luo ◽  
Juemin Xi ◽  
Xiaodan Wang ◽  
...  
Keyword(s):  
Sequence Analysis ◽  
Regulatory Sequence ◽  
Coding Region ◽  
Semaphorin 4D

scholarly journals Woot, an Active Gypsy-Class Retrotransposon in the Flour Beetle, Tribolium castaneum, is Associated With a Recent Mutation

Genetics ◽  
1996 ◽  
Vol 143 (1) ◽  
pp. 417-426
Author(s):  
Richard W Beeman ◽  
M Scott Thomson ◽  
John M Clark ◽  
Marco A DeCamillis ◽  
Susan J Brown ◽  
...  
Keyword(s):  
Sequence Analysis ◽  
Tribolium Castaneum ◽  
Frameshift Mutation ◽  
Open Reading Frames ◽  
Red Flour Beetle ◽  
Intron Sequence ◽  
Coding Region ◽  
Long Terminal Repeats ◽  
Flour Beetle ◽  
Reading Frames

Abstract A recently isolated, lethal mutation of the homeotic Abdominal gene of the red flour beetle Tribolium castaneum is associated with an insertion of a novel retrotransposon into an intron. Sequence analysis indicates that this retrotransposon, named Woot, is a member of the gypsy family of mobile elements. Most strains of T. castaneum appear to harbor ~25-35 copies of Woot per genome. Woot is composed of long terminal repeats of unprecedented length (3.6 kb each), flanking an internal coding region 5.0 kb in length. For most copies of Woot, the internal region includes two open reading frames (ORFs) that correspond to the gag and pol genes of previously described retrotransposons and retroviruses. The copy of Woot inserted into Abdominal bears an apparent single frameshift mutation that separates the normal second ORF into two. Woot does not appear to generate infectious virions by the criterion that no envelop gene is discernible. The association of Woot with a recent mutation suggests that this retroelement is currently transpositionally active in at least some strains.

scholarly journals RSAT 2011: regulatory sequence analysis tools

2011 ◽  
Vol 39 (suppl) ◽  
pp. W86-W91 ◽  
Author(s):  
M. Thomas-Chollier ◽  
M. Defrance ◽  
A. Medina-Rivera ◽  
O. Sand ◽  
C. Herrmann ◽  
...  
Keyword(s):  
Sequence Analysis ◽  
Regulatory Sequence ◽  
Analysis Tools

scholarly journals Structural genes of the mouse major urinary protein are on chromosome 4.

1982 ◽  
Vol 94 (2) ◽  
pp. 414-417 ◽  
Author(s):  
K Krauter ◽  
L Leinwand ◽  
P D'Eustachio ◽  
F Ruddle ◽  
J E Darnell
Keyword(s):  
Protein Synthesis ◽  
Sequence Analysis ◽  
Chromosome 4 ◽  
Structural Genes ◽  
Urinary Proteins ◽  
Coding Region ◽  
Somatic Cell Genetics ◽  
Major Urinary Protein ◽  
Major Urinary Proteins ◽  
Trans Regulation

The major urinary proteins (MUPs) of mouse are a family of at least three major proteins which are synthesized in the liver of all strains of mice. The relative levels of synthesis of these proteins with respect to each other in the presence of testosterone is regulated by the Mup-a locus located on chromosome 4. In an effort to determine the mechanism of this regulation in molecular terms, a cDNA clone containing most of the coding region of a MUP protein has been isolated and identified by partial DNA sequence analysis. Using a combination of hybridization analysis and somatic cell genetics, the structural gene family has been unambiguously mapped to mouse chromosome 4. These data suggest that Mup-a regulation operates in a cis fashion and that models proposing trans regulation of MUP protein synthesis are unlikely.

Simple PCR Amplification of the Entire Glucocerebrosidase Gene (GBA) Coding Region for Diagnostic Sequence Analysis

DNA Sequence ◽  
1998 ◽  
Vol 8 (6) ◽  
pp. 349-356 ◽  
Author(s):  
Ulrich Finckh ◽  
Pavel Seeman ◽  
Oldrik Cardinal von Widdern ◽  
Arndt Rolfs
Keyword(s):  
Sequence Analysis ◽  
Pcr Amplification ◽  
Coding Region ◽  
Glucocerebrosidase Gene

Sequence analysis of the 5′ non coding region of Turkish HCV isolates: implications for PCR diagnosis

1996 ◽  
Vol 5 (2-3) ◽  
pp. 211-214 ◽  
Author(s):  
Y.Hakan Abacioğlu ◽  
Fiona Davidson ◽  
Peter Simmonds
Keyword(s):  
Sequence Analysis ◽  
Coding Region ◽  
Pcr Diagnosis

Sequence analysis of the ADRA2A coding region in children affected by attention deficit hyperactivity disorder

2013 ◽  
Vol 34 (12) ◽  
pp. 2219-2222 ◽  
Author(s):  
Taryn Castro ◽  
Heidi Eliana Mateus ◽  
Dora Janeth Fonseca ◽  
Diego Forero ◽  
Carlos Martín Restrepo ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Sequence Analysis ◽  
Attention Deficit ◽  
Coding Region ◽  
Hyperactivity Disorder

scholarly journals TET2 Mutations in Ph-Negative Myeloproliferative Neoplasms: Identification of Three Novel Mutations and Relationship with Clinical and Laboratory Findings

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Andrea Patriarca ◽  
Donatella Colaizzo ◽  
Gianluca Tiscia ◽  
Raffaele Spadano ◽  
Silvia Di Zacomo ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Sequence Analysis ◽  
Essential Thrombocythemia ◽  
Myeloproliferative Neoplasms ◽  
Jak2 V617f ◽  
Primary Myelofibrosis ◽  
Coding Region ◽  
Novel Mutations ◽  
Laboratory Findings ◽  
Mutational Frequency

High-throughput DNA sequence analysis was used to screen for TET2 mutations in peripheral blood derived DNA from 97 patients with BCR-ABL-negative myeloproliferative neoplasms (MPNs). Overall six mutations in the coding region of the gene were identified in 7 patients with an overall mutational frequency of 7.2%. In polycythemia vera patients (n=25) 2 mutations were identified (8%), and in those with essential thrombocythemia (n=55) 2 mutations (3.6%); in those with unclassifiable MPN (n=8) 3 mutations (37.5%). No primary myelofibrosis patients (n=6) harboured TET2 mutations. Three unreported mutations were identified (p.P177fs, p.C1298del, and p.P411del), the first two in patients with unclassifiable MPN, the last in a patient with essential thrombocythemia. On multivariate analysis the diagnosis of an unclassifiable MPN was significantly related to the presence of TET2 mutations (P=0.02; OR: 2.81; 95% CI 1.11–7.06). We conclude that TET2 mutations occur in both JAK2 V617F-positive and -negative MPNs and are more frequent in MPN-U patients. This could represent the biological link between the different classes of myeloid malignancies.

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