scholarly journals FABP1 Polymorphisms Contribute to Hepatocellular Carcinoma Susceptibility in Chinese Population with Liver Cirrhosis: A Case-Control Study

2018 ◽  
Vol 9 (22) ◽  
pp. 4294-4300 ◽  
Author(s):  
Meng Wang ◽  
Xinghan Liu ◽  
Shuai Lin ◽  
Tian Tian ◽  
Feng Guan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Chinese Population ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

CASP 3 genetic polymorphisms and risk of Hepatocellular carcinoma: a case-control study in a Chinese population

Tumor Biology ◽  
2016 ◽  
Vol 37 (7) ◽  
pp. 8985-8991 ◽  
Author(s):  
Benyuan Deng ◽  
Fei Liu ◽  
Limei Luo ◽  
Yonggang Wei ◽  
Bo Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Genetic Polymorphisms ◽  
Chinese Population ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

Association of TNF-α Genetic Polymorphisms with Hepatocellular Carcinoma Susceptibility: A Case-Control Study in a Han Chinese Population

2011 ◽  
Vol 26 (3) ◽  
pp. 181-187 ◽  
Author(s):  
Xiangmei Chen ◽  
Ling Zhang ◽  
Yibin Chang ◽  
Tao Shen ◽  
Ling Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chinese Population ◽  
Case Control Study ◽  
Case Control ◽  
Han Chinese ◽  
Nucleotide Polymorphisms ◽  
Han Chinese Population ◽  
Direct Dna Sequencing ◽  
Tnf Α ◽  
Control Study

The single nucleotide polymorphisms (SNPs) within the tumor necrosis factor-α (TNF-α) gene promoter region have been reported to be associated with susceptibility to various types of cancers. A case-control study (126 hepatocellular carcinoma [HCC] patients and 126 normal controls) was conducted to elucidate their possible association with the risk of hepatitis B virus (HBV)-related HCC in a Han Chinese population. TNF-α polymorphisms -1031T/C, -863C/A, -857C/T, -308G/A, and -238G/A were genotyped by polymerase chain reaction (PCR) and direct DNA sequencing. Disease associations were analyzed by the chi-square test or Fisher's exact test. When analyzed by overall groups, no significant differences in genotype and allele distributions were observed between the control and cases. However, stratified analysis according to sex showed that the frequency of the homozygous C allele of the -857 polymorphism was lower in female cases than in female controls (62.9% vs. 88.9%, p=0.026). In addition, further haplotype analysis revealed that the TCCGA (-1031/-863/-857/-308/-238) was more frequent in controls than cases (p=0.018; odds ratio = 0.266; 95% confidence interval, 0.083–0.857). These results indicated that the TNF-α-857C/T polymorphism may modify HBV-related HCC risk among women, and the haplotype TCCGA (-1031/-863/-857/-308/-238) may account for a decreased susceptibility to HCC development in the Han Chinese population. Additional studies in patients with different ethnic backgrounds are needed to validate these finding and to further explore the genetic pathogenesis of HBV-related HCC.

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