scholarly journals Surrogate endpoints shortening the therapeutic evaluation duration for different subgroups of patients with nasopharyngeal carcinoma receiving intensity-modulated radiotherapy: A retrospective analysis of 830 patients stratified by the 8th edition of the UICC/AJCC staging system and plasma Epstein-Barr viral

2018 ◽  
Vol 9 (18) ◽  
pp. 3352-3360 ◽  
Author(s):  
Shu Zhou ◽  
Chen Chen ◽  
Song-ran Liu ◽  
Ya-lan Tao ◽  
Hui Chang ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Intensity Modulated Radiotherapy ◽  
Staging System ◽  
Surrogate Endpoints ◽  
Intensity Modulated ◽  
Therapeutic Evaluation ◽  
Ajcc Staging System ◽  
Epstein Barr ◽  
Ajcc Staging ◽  
8Th Edition

scholarly journals Comparison of The 7th and 8th Editions of The Union for International Cancer Control /American Joint Committee on Cancer Staging System for Nonmetastatic Nasopharyngeal Carcinoma in The Intensity-Modulated Radiotherapy Era

2020 ◽  
Author(s):  
Tao He ◽  
Ruo-Nan Yan ◽  
Hua-Ying Chen ◽  
Yuan-Yuan Zeng ◽  
Zhong-Zheng Xiang ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Intensity Modulated Radiotherapy ◽  
Cancer Control ◽  
Staging System ◽  
Intensity Modulated ◽  
7Th Edition ◽  
N Classification ◽  
Ajcc Staging System ◽  
Ajcc Staging ◽  
T Classification

Abstract Background: To compare the prognostic value of 7th and 8th editions of the Union for International Cancer Control /American Joint Committee on Cancer (AJCC) staging system for patients with nonmetastatic nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy and simultaneous integrated boost– intensity-modulated radiation therapy (SIB-IMRT).Methods: Patients with NPC (n = 300) who received SIB-IMRT were included. Survival by T-classification, N-classification, and stage group of each staging system was assessed.Results: For T-classification, nonsignificant difference was observed between T1 and T2 and between T2 and T3 disease (P = 0.066 and 0.106, respectively) for overall survival (OS) in the 7th staging system, whereas all these differences were significant in the 8th staging system (all P < 0.05). The survival curves for disease-free survival (DFS) and LRFS in both staging systems were similar, except for the comparison of T2 and T4 disease for LRFS (P = 0.07 for 7th edition; P = 0.011 for 8th edition). For N-classification, significant differences were observed between N2 and N3 diseases after revision (P = 0.046 and P = 0.043 for OS and DFS, respectively). For staging system, no significant difference was observed between IVA and IVB of 7th edition.Conclusion: The 8th AJCC staging system appeared to have superior prognosis value in the SIB-IMRT era compared with the 7th edition.

scholarly journals Comparing the 7th and 8th editions of UICC/AJCC staging system for nasopharyngeal carcinoma in the IMRT era

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Tao He ◽  
Ruo-Nan Yan ◽  
Hua-Ying Chen ◽  
Yuan-Yuan Zeng ◽  
Zhong-Zheng Xiang ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Staging System ◽  
Free Survival ◽  
Intensity Modulated ◽  
7Th Edition ◽  
Staging Systems ◽  
N Classification ◽  
Ajcc Staging System ◽  
Ajcc Staging ◽  
T Classification

Abstract Background To compare the prognostic value of 7th and 8th editions of the Union for International Cancer Control/American Joint Committee on Cancer (UICC/AJCC) staging system for patients with nonmetastatic nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy and simultaneous integrated boost– intensity-modulated radiation therapy (SIB-IMRT). Methods Patients with NPC (n = 300) who received SIB-IMRT were included. Survival by T-classification, N-classification, and stage group of each staging system was assessed. Results For T-classification, nonsignificant difference was observed between T1 and T3 and between T2 and T3 disease (P = 0.066 and 0.106, respectively) for overall survival (OS) in the 7th staging system, whereas all these differences were significant in the 8th staging system (all P < 0.05). The survival curves for disease-free survival (DFS) and locoregional recurrence-free survival (LRRFS) in both staging systems were similar, except for the comparison of T2 and T4 disease for LRRFS (P = 0.070 for 7th edition; P = 0.011 for 8th edition). For N-classification, significant differences were observed between N2 and N3 diseases after revision (P = 0.046 and P = 0.043 for OS and DFS, respectively). For staging system, no significant difference was observed between IVA and IVB of 7th edition. Conclusion The 8th AJCC staging system appeared to have superior prognosis value in the SIB-IMRT era compared with the 7th edition.

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