scholarly journals Angiopoietin-like Protein 2 is a Useful Biomarker for Pancreatic Cancer that is Associated with Type 2 Diabetes Mellitus and Inflammation

2018 ◽  
Vol 9 (24) ◽  
pp. 4736-4741 ◽  
Author(s):  
Takuma Yoshinaga ◽  
Tatsuyuki Niou ◽  
Toru Niihara ◽  
Yoriko Kajiya ◽  
Emiko Hori ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Pancreatic Cancer ◽  
Type 2 Diabetes Mellitus

Cytokines as potential biomarkers for distinguishing patients with pancreatic cancer and type 2 diabetes mellitus

Pancreatology ◽  
2017 ◽  
Vol 17 (3) ◽  
pp. S33
Author(s):  
Rohith Gopala Rao ◽  
Lucy Oldfield ◽  
Anthony Evans ◽  
Lavanya Sivapalan ◽  
Philip Schuler ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Pancreatic Cancer ◽  
Type 2 Diabetes Mellitus ◽  
Potential Biomarkers

scholarly journals Type 2 Diabetes Mellitus Intersects With Pancreatic Cancer Diagnosis and Development

2021 ◽  
Vol 11 ◽  
Author(s):  
Xiaoye Duan ◽  
Weihao Wang ◽  
Qi Pan ◽  
Lixin Guo
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Pancreatic Cancer ◽  
Type 2 Diabetes Mellitus ◽  
Cancer Diagnosis ◽  
Complex Diabetes ◽  
The Relationship ◽  
Early Manifestation ◽  
New Onset

The relationship between type 2 diabetes mellitus (T2DM) and pancreatic cancer (PC) is complex. Diabetes is a known risk factor for PC, and new-onset diabetes (NOD) could be an early manifestation of PC that may be facilitate the early diagnosis of PC. Metformin offers a clear benefit of inhibiting PC, whereas insulin therapy may increase the risk of PC development. No evidence has shown that novel hypoglycemic drugs help or prevent PC. In this review, the effects of T2DM on PC development are summarized, and novel strategies for the prevention and treatment of T2DM and PC are discussed.

scholarly journals Effect of type 2 diabetes mellitus on survival in metastatic pancreatic cancer

2021 ◽  
Vol 5 (1) ◽  
pp. 17-21
Author(s):  
Ayşegül SAKİN ◽  
Suleyman SAHİN ◽  
Abdullah SAKİN ◽  
Muhammed ATCİ ◽  
Çağlayan GEREDELİ ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Pancreatic Cancer ◽  
Type 2 Diabetes Mellitus ◽  
Metastatic Pancreatic Cancer

scholarly journals Type 2 diabetes mellitus is associated with increased risk of pancreatic cancer: A veteran administration registry study

2016 ◽  
Vol 4 ◽  
pp. 205031211668225 ◽  
Author(s):  
Issam Makhoul ◽  
Abdulraheem Yacoub ◽  
Eric Siegel
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Pancreatic Cancer ◽  
Type 2 Diabetes Mellitus ◽  
Veteran Administration ◽  
Healthcare Facility ◽  
Administrative Database ◽  
Increased Risk ◽  
Rising Incidence

Background: The etiology of pancreatic cancer remains elusive. Several studies have suggested a role for diabetes mellitus, but the magnitude of its contribution remains controversial. Objectives: Utilizing a large administrative database, this retrospective cohort study was designed to investigate the relationship between type 2 diabetes mellitus and pancreatic cancer. Patients and design: Using the Veterans Integrated Services Network 16 database, 322,614 subjects were enrolled in the study, including 110,919 with type 2 diabetes mellitus and 211,695 diabetes-free controls matched by gender, year of birth and healthcare facility. Results: A significantly higher incidence of pancreatic cancer was observed in patients with type 2 diabetes mellitus, with an adjusted hazard ratio (95% confidence interval) of 2.17 (1.70–2.77) for type 2 diabetes mellitus compared to controls (p < 10−9) after controlling for the matching factors. Conclusion: The association between type 2 diabetes mellitus and pancreatic cancer was statistically significant and may, in part, explain the rising incidence of pancreatic cancer.

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