scholarly journals Functional Genome-wide Screening Identifies Targets and Pathways Sensitizing Pancreatic Cancer Cells to Dasatinib

2018 ◽  
Vol 9 (24) ◽  
pp. 4762-4773 ◽  
Author(s):  
Wenwen Chien ◽  
Makoto Sudo ◽  
Ling-Wen Ding ◽  
Qiao-Yang Sun ◽  
Peer Wuensche ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Pancreatic Cancer Cells ◽  
Genome Wide ◽  
Functional Genome

scholarly journals Genome-Wide Screening Reveals an EMT Molecular Network Mediated by Sonic Hedgehog-Gli1 Signaling in Pancreatic Cancer Cells

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e43119 ◽  
Author(s):  
Xuanfu Xu ◽  
Yingqun Zhou ◽  
Chuangao Xie ◽  
Shu-mei Wei ◽  
Huizhong Gan ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Sonic Hedgehog ◽  
Molecular Network ◽  
Pancreatic Cancer Cells ◽  
Genome Wide

scholarly journals The Significance of Targeting Poly (ADP-Ribose) Polymerase-1 in Pancreatic Cancer for Providing a New Therapeutic Paradigm

2021 ◽  
Vol 22 (7) ◽  
pp. 3509
Author(s):  
Keun-Yeong Jeong ◽  
Min Hee Park
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Cancer Progression ◽  
Adenosine Diphosphate ◽  
Pancreatic Cancer Cells ◽  
Distinct Subpopulation ◽  
Genome Wide ◽  
Cancer Cell Survival ◽  
Survival And Growth ◽  
Parp 1

Genome-wide studies focusing on elucidating the effects on cancer progression have enabled the consequent identification of a distinct subpopulation of pancreatic cancer cells with unstable genomic characteristics. Based on this background, deleterious changes by poly (adenosine diphosphate (ADP)-ribose) polymerase-1 (PARP)-1 have been concentrated in oncology. One of the critical functions of PARP-1 is the response to DNA damage, which plays a pivotal role in DNA repair in cancers. PARP-1 also has widespread functions that are essential for the survival and growth of cancer cells. It regulates oxidative stress in mitochondria through the regulation of superoxide and oxidation. PARP-1 is in charge of regulating mitosis, which is a crucial role in tumorigenesis and remodels histones and chromatin enzymes related to transcriptional regulation, causing alterations in epigenetic markers and chromatin structure. Given the significance of these processes, it can be understood that these processes in cancer cells are at the frontline of the pathogenetic changes required for cancer cell survival, and these contributions can result in malignant transformation. Therefore, this review addresses the current molecular biological features for understanding the multifactorial function of PARP-1 in pancreatic cancer related to the aforementioned roles, along with the summary of recent approaches with PARP-1 inhibition in clinical studies targeting pancreatic cancer. This understanding could help to embrace the importance of targeting PARP-1 in the treatment of pancreatic cancer, which may present the potential to find out a variety of research topics that can be both challenged clinically and non-clinically.

scholarly journals Genome-wide gene loss in human pancreatic cancer cells

2008 ◽  
Vol 16 (17) ◽  
pp. 1849
Author(s):  
Lian-Jie Lin ◽  
Yu-Feng Wang ◽  
Chang-Qing Zheng ◽  
Yu Jin ◽  
Gang-Zheng Hu ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Gene Loss ◽  
Human Pancreatic Cancer ◽  
Pancreatic Cancer Cells ◽  
Genome Wide

scholarly journals Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Jesse Bakke ◽  
William C. Wright ◽  
Anthony E. Zamora ◽  
Peter Oladimeji ◽  
Jeremy Chase Crawford ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Essential Gene ◽  
Pancreatic Cancer Cells ◽  
Genome Wide ◽  
Crispr Screen
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