scholarly journals Nomograms and risk scores for predicting the risk of oral cancer in different sexes: a large-scale case-control study

2018 ◽  
Vol 9 (14) ◽  
pp. 2543-2548 ◽  
Author(s):  
Fa Chen ◽  
Lisong Lin ◽  
Lingjun Yan ◽  
Fengqiong Liu ◽  
Yu Qiu ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Large Scale ◽  
Case Control Study ◽  
Case Control ◽  
Risk Scores ◽  
Control Study

Serum copper and zinc levels and the risk of oral cancer: A new insight based on large‐scale case–control study

Oral Diseases ◽  
2018 ◽  
Vol 25 (1) ◽  
pp. 80-86 ◽  
Author(s):  
Fa Chen ◽  
Jing Wang ◽  
Jinfa Chen ◽  
Lingjun Yan ◽  
Zhijian Hu ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Large Scale ◽  
Case Control Study ◽  
Case Control ◽  
Serum Copper ◽  
Copper And Zinc ◽  
Zinc Levels ◽  
Control Study

scholarly journals COVID-19 and Its Symptoms’ Panoply: A Case-Control Study of 919 Suspected Cases in Locked-Down Ovar, Portugal

2021 ◽  
pp. 1-8
Author(s):  
Regina Sá ◽  
Tiago Pinho-Bandeira ◽  
Guilherme Queiroz ◽  
Joana Matos ◽  
João Duarte Ferreira ◽  
...  
Keyword(s):  
Large Scale ◽  
Case Control Study ◽  
Statistical Significance ◽  
Case Control ◽  
Case Definition ◽  
Suspected Case ◽  
Risk Characteristics ◽  
Increased Risk ◽  
Wide Range ◽  
Control Study

<b><i>Background:</i></b> Ovar was the first Portuguese municipality to declare active community transmission of SARS-CoV-2, with total lockdown decreed on March 17, 2020. This context provided conditions for a large-scale testing strategy, allowing a referral system considering other symptoms besides the ones that were part of the case definition (fever, cough, and dyspnea). This study aims to identify other symptoms associated with COVID-19 since it may clarify the pre-test probability of the occurrence of the disease. <b><i>Methods:</i></b> This case-control study uses primary care registers between March 29 and May 10, 2020 in Ovar municipality. Pre-test clinical and exposure-risk characteristics, reported by physicians, were collected through a form, and linked with their laboratory result. <b><i>Results:</i></b> The study population included a total of 919 patients, of whom 226 (24.6%) were COVID-19 cases and 693 were negative for SARS-CoV-2. Only 27.1% of the patients reporting contact with a confirmed or suspected case tested positive. In the multivariate analysis, statistical significance was obtained for headaches (OR 0.558), odynophagia (OR 0.273), anosmia (OR 2.360), and other symptoms (OR 2.157). The interaction of anosmia and odynophagia appeared as possibly relevant with a borderline statistically significant OR of 3.375. <b><i>Conclusion:</i></b> COVID-19 has a wide range of symptoms. Of the myriad described, the present study highlights anosmia itself and calls for additional studies on the interaction between anosmia and odynophagia. Headaches and odynophagia by themselves are not associated with an increased risk for the disease. These findings may help clinicians in deciding when to test, especially when other diseases with similar symptoms are more prevalent, namely in winter.

scholarly journals Dietary patterns and risk of oral cancer: a case-control study in São Paulo, Brazil

2007 ◽  
Vol 41 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Dirce Maria Lobo Marchioni ◽  
Regina Mara Fisberg ◽  
José Francisco de Góis Filho ◽  
Luiz Paulo Kowalski ◽  
Marcos Brasilino de Carvalho ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Dietary Patterns ◽  
Case Control Study ◽  
Case Control ◽  
Sao Paulo ◽  
Southeastern Brazil ◽  
P Value ◽  
São Paulo ◽  
Factor Scores ◽  
Control Study

OBJECTIVE: To analyze the association between dietary patterns and oral cancer. METHODS: The study, part of a Latin American multicenter hospital-based case-control study, was conducted in São Paulo, Southeastern Brazil, between November 1998 and March 2002 and included 366 incident cases of oral cancer and 469 controls, frequency-matched with cases by sex and age. Dietary data were collected using a food frequency questionnaire. The risk associated with the intake of food groups defined a posteriori, through factor analysis (called factors), was assessed. The first factor, labeled "prudent," was characterized by the intake of vegetables, fruit, cheese, and poultry. The second factor, "traditional," consisted of the intake of rice, pasta, pulses, and meat. The third factor, "snacks," was characterized as the intake of bread, butter, salami, cheese, cakes, and desserts. The fourth, "monotonous," was inversely associated with the intake of fruit, vegetables and most other food items. Factor scores for each component retained were calculated for cases and controls. After categorization of factor scores into tertiles according to the distribution of controls, odds ratios and 95% confidence intervals were calculated using unconditional multiple logistic regression. RESULTS: "Traditional" factor showed an inverse association with cancer (OR=0.51; 95% CI: 0.32; 0.81, p-value for trend 0.14), whereas "monotonous" was positively associated with the outcome (OR=1.78; 95% CI: 1.78; 2.85, p-value for trend <0.001). CONCLUSIONS: The study data suggest that the traditional Brazilian diet, consisting of rice and beans plus moderate amounts of meat, may confer protection against oral cancer, independently of any other risk factors such as alcohol intake and smoking.

scholarly journals Tinnitus severity correlated with zinc, copper, risk factors: a large-scale case-control study

Authorea ◽  
2020 ◽  
Author(s):  
Jiangfeng Huang ◽  
Jing He ◽  
Qingping Zhu ◽  
Zhiwei Zheng ◽  
Peiji Zeng ◽  
...  
Keyword(s):  
Risk Factors ◽  
Large Scale ◽  
Case Control Study ◽  
Case Control ◽  
Tinnitus Severity ◽  
Control Study

scholarly journals Association of Mesothelioma Deaths With Cumulated Neighborhood Exposures Due to a Large-Scale Asbestos Cement Plant in Amagasaki City, Japan: A Nested Case-control Study

2021 ◽  
Author(s):  
Yuri Kitamura ◽  
Ling Zha ◽  
Rong Liu ◽  
Masayuki Shima ◽  
Tomoki Nakaya ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Large Scale ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Asbestos Exposure ◽  
Case Control ◽  
Asbestos Cement ◽  
Nested Case Control ◽  
Dose Dependent ◽  
Control Study

Abstract BackgroundAlthough a causal relationship between mesothelioma and asbestos exposure is well known, few studies have shown a relationship to non-occupational exposure, including neighborhood exposure, most likely because of the large effect size of occupational exposure. The aim of this study was to quantify the risk of malignant mesothelioma death associated with neighborhood asbestos exposure due to a large-scale asbestos-cement (AC) plant in Amagasaki, Japan, by properly adjusting for occupational exposure. MethodsThis was a nested case-control study in which a fixed population of 143,929 residents who had been living in Amagasaki City between 1975 and 2002 were followed from 2002 to 2015. All 133 cases and 403 matched controls were interviewed about their occupational, domestic, household, and neighborhood asbestos exposures. Odds ratios (ORs) for mesothelioma death associated with neighborhood exposure were estimated by a conditional logistic-regression model that adjusted for other asbestos exposures. We adopted cumulative indices that considered residence-specific asbestos (crocidolite) concentrations and durations during the potential exposure period of 1957-1975 to evaluate individual neighborhood exposures.ResultsThere was an increasing, dose-dependent risk of mesothelioma death associated with neighborhood exposure, demonstrated by ORs in the highest quintile category that were 21.4 (95%CI: 5.8 to 79.2) for all, 23.7 (95% CI: 3.8-147.2) for males and 26.0 (95% CI: 2.8-237.5) for females, compared to the lowest quintile, respectively. These results clearly demonstrated no substantial differences between males and females in relation to the magnitude of risk from neighborhood exposure.Our findings suggest that the risk of mesothelioma death associated with neighborhood exposure persists and will not be diminished for many years, even though it has been decades since the AC plant closed. ConclusionsBy adjusting for occupational and other asbestos exposures, a dose-dependent relationship was demonstrated between mesothelioma death and neighborhood asbestos exposure from a large-scale AC plant.

scholarly journals Does Parkinson's Disease Increase the Risk of Atrial Fibrillation? Insights From Electrocardiogram and Risk Scores From a Case-Control Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Mariana Alves ◽  
Ana Mafalda Abrantes ◽  
Gonçalo Portugal ◽  
M. Manuela Cruz ◽  
Sofia Reimão ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Case Control Study ◽  
Case Control ◽  
P Wave ◽  
Risk Scores ◽  
Wave Duration ◽  
P Wave Duration ◽  
Increased Risk ◽  
The Mean ◽  
Control Study

Background: Previous studies suggested that Parkinson's Disease (PD) patients could have an increased risk of atrial fibrillation. However, data supporting this association is not robust. We aimed to compare the potential risk of atrial fibrillation associated with PD in an age and gender matched case-control study, comparing the p-wave indexes from electrocardiograms and clinical risk scores among groups.Methods: A cross-sectional case-control study was performed. All subjects included in the analysis were clinically evaluated and subjected to a 12-lead electrocardiogram. Two blinded independent raters measured the p-wave duration. Subjects were classified as having normal P-wave duration (&lt;120 ms), partial IAB (P-wave duration ≥ 120 ms, positive in inferior leads), and advanced IAB (p-wave duration ≥ 120 ms with biphasic morphology in inferior leads). Atrial fibrillation risk scores (CHARGE-AF, HATCH, and HAVOC) were calculated.Results: From 194 potential participants, three were excluded from the control group due to a previous diagnosis of atrial fibrillation. Comparing the PD patients (n = 97) with controls (n = 95), there were no statistically significant differences regarding the mean p-wave duration (121 ms vs. 122 ms, p = 0.64) and proportion of advanced interatrial block (OR = 1.4, 95%CI = 0.37–5.80, p = 0.58). All patients had a low or medium risk of developing atrial fibrillation based on the clinical scores. There were no differences between the PD patients and controls regarding the mean values of CHARGE-AF, HATCH, and HAVOC.Conclusions: Our results do not support the hypothesis that PD patients have an increased risk of atrial fibrillation based on the p-wave predictors and atrial fibrillation clinical scores.

Influence of CYP1A1, CYP2E1, GSTM3 and NAT2 genetic polymorphisms in oral cancer susceptibility: Results from a case-control study in Rio de Janeiro

Oral Oncology ◽  
2006 ◽  
Vol 42 (6) ◽  
pp. 632-637 ◽  
Author(s):  
Christiane F.S. Marques ◽  
Sérgio Koifman ◽  
Rosalina J. Koifman ◽  
Paolo Boffetta ◽  
Paul Brennan ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Genetic Polymorphisms ◽  
Rio De Janeiro ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Case Control ◽  
Control Study

scholarly journals Independent and joint effects of tea and milk consumption on oral cancer among non-smokers and non-drinkers: a case-control study in China

Oncotarget ◽  
2017 ◽  
Vol 8 (30) ◽  
pp. 50091-50097 ◽  
Author(s):  
Fa Chen ◽  
Lingjun Yan ◽  
Lisong Lin ◽  
Fengqiong Liu ◽  
Yu Qiu ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Milk Consumption ◽  
Joint Effects ◽  
Control Study
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