scholarly journals The latest exploration of staging and prognostic classification for pancreatic neuroendocrine tumors: a large population-based study

2018 ◽  
Vol 9 (9) ◽  
pp. 1698-1706 ◽  
Author(s):  
Shanshan Gao ◽  
Ning Pu ◽  
Lingxiao Liu ◽  
Changyu Li ◽  
Xuefeng Xu ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Large Population ◽  
Population Based ◽  
Pancreatic Neuroendocrine Tumors ◽  
Population Based Study

scholarly journals A Nationwide Population-Based Study on the Survival of Patients with Pancreatic Neuroendocrine Tumors in The Netherlands

2017 ◽  
Vol 42 (2) ◽  
pp. 490-497 ◽  
Author(s):  
C. G. Genc ◽  
H. J. Klümpen ◽  
M. G. H. van Oijen ◽  
C. H. J. van Eijck ◽  
E. J. M. Nieveen van Dijkum
Keyword(s):  
The Netherlands ◽  
Neuroendocrine Tumors ◽  
Population Based ◽  
Pancreatic Neuroendocrine Tumors ◽  
Population Based Study

scholarly journals The impact of surgery in metastatic pancreatic neuroendocrine tumors: a competing risk analysis

2019 ◽  
Vol 8 (3) ◽  
pp. 239-251 ◽  
Author(s):  
Chao-bin He ◽  
Yu Zhang ◽  
Zhi-yuan Cai ◽  
Xiao-jun Lin
Keyword(s):  
Neuroendocrine Tumors ◽  
Cox Regression ◽  
Large Population ◽  
Population Based ◽  
Study Cohort ◽  
Pancreatic Neuroendocrine Tumors ◽  
Cancer Specific Survival ◽  
Discriminative Ability ◽  
Stage System ◽  
The Impact

Aim The role of surgery in the treatment of metastatic pancreatic neuroendocrine tumors (PNETs) was controversial. The objectives of this study were to illustrate the impact of surgery in improving the prognosis of patients with metastatic PNETs and build nomograms to predict overall survival (OS) and cancer-specific survival (CSS) based on a large population-based cohort. Methods Patients diagnosed with metastatic PNETs between 2004 and 2015 from the Surveillance, Epidemiology, and End Results (SEER) database were retrospectively collected. Nomograms for estimating OS and CSS were established based on Cox regression model and Fine and Grey’s model. The precision of the nomograms was evaluated and compared using concordance index (C-index) and the area under receiver operating characteristic (ROC) curve (AUC). Results The study cohort included 1966 patients with metastatic PNETs. It was shown that the surgery provided survival benefit for all groups of patients with metastatic PNETs. In the whole study cohort, 1-, 2- and 3-year OS and CSS were 51.5, 37.1 and 29.4% and 53.0, 38.9 and 31.1%, respectively. The established nomograms were well calibrated, and had good discriminative ability, with C-indexes of 0.773 for OS prediction and 0.774 for CSS prediction. Conclusions Patients with metastatic PNETs could benefit from surgery when the surgery tolerance was acceptable. The established nomograms could stratify patients who were categorized as tumor-node-metastasis (TNM) IV stage into groups with diverse prognoses, showing better discrimination and calibration of the established nomograms, compared with 8th TNM stage system in predicting OS and CSS for patients with metastatic PNETs.

scholarly journals Incidence of patients with bone metastases at diagnosis of solid tumors in adults: a large population-based study

2020 ◽  
Vol 8 (7) ◽  
pp. 482-482 ◽  
Author(s):  
Jin-Feng Huang ◽  
Jianfei Shen ◽  
Xiao Li ◽  
Ramesh Rengan ◽  
Nicola Silvestris ◽  
...  
Keyword(s):  
Bone Metastases ◽  
Solid Tumors ◽  
Large Population ◽  
Population Based ◽  
Population Based Study
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