scholarly journals Association between the SNPs of the TOB1 gene and gastric cancer risk in the Chinese Han population of northeast China

2018 ◽  
Vol 9 (8) ◽  
pp. 1371-1378 ◽  
Author(s):  
Hui Wang ◽  
Huiting Hao ◽  
Haonan Guo ◽  
Yuanyuan Wang ◽  
Xuelong Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Northeast China ◽  
Chinese Han Population ◽  
Gastric Cancer Risk ◽  
Chinese Han ◽  
Han Population

scholarly journals Prediction of gastric cancer risk: association between ZBTB20 genetic variance and gastric cancer risk in Chinese Han population

2020 ◽  
Vol 40 (9) ◽  
Author(s):  
Fei Bai ◽  
Ke Xiao
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Clinical Characteristics ◽  
Protective Factor ◽  
Univariate Analysis ◽  
Genetic Models ◽  
Chinese Han Population ◽  
Gastric Cancer Risk ◽  
Chinese Han ◽  
Han Population

Abstract Background: Gastric cancer (GC) is a complex multifactorial disease. Previous studies have revealed genetic variations associated with the risk of gastric cancer. The purpose of the present study was to determine the correlation between single-nucleotide polymorphisms (SNPs) of ZBTB20 and the risk of gastric cancer in Chinese Han population. Methods: We conducted a ‘case–control’ study involving 509 GC patients and 507 healthy individuals. We selected four SNPs of ZBTB20 (10934270 T/C, rs9288999 G/A, rs9841504 G/C and rs73230612 C/T), and used logistic regression to analyze the relationship between those SNPs and GC risk under different genetic models; multi-factor dimensionality reduction (MDR) was used to analyze the interaction of “SNP–SNP” in gastric cancer risk; ANOVA and univariate analysis were used to analyze the differences in clinical characteristics among different genotypes. Results: Our results showed that ZBTB20 rs9288999 is a protective factor for the risk of gastric cancer in multiple genetic models, of which the homozygous model is the most significant (OR = 0.48, P=0.0003); we also found that rs9288999 showed a significant correlation with reducing the risk of gastric cancer in different subgroups (BMI; age; gender; smoking or drinking status; adenocarcinoma); rs9841504 is associated with increased GC risk in the participants with BMI>24 kg/m2; rs9841504 and rs73230612 are certainly associated with clinical characteristics of platelet and carbohydrate antigen 242, respectively. Conclusion: Our results suggest that ZBTB20 rs9288999 may be important for reducing the risk of GC in the Chinese Han population.

Genetic variants in Ras/Raf/MEK/ERK pathway are associated with gastric cancer risk in Chinese Han population

2020 ◽  
Vol 94 (8) ◽  
pp. 2683-2690 ◽  
Author(s):  
Xiaowei Wang ◽  
Xu Wu ◽  
Junyi Xin ◽  
Shuwei Li ◽  
Rui Zheng ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Genetic Variants ◽  
Chinese Han Population ◽  
Erk Pathway ◽  
Gastric Cancer Risk ◽  
Chinese Han ◽  
Han Population

scholarly journals Associations of the MTHFR rs1801133 polymorphism with gastric cancer risk in the Chinese Han population

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Zhiqiang Han ◽  
Huaming Sheng ◽  
Qiuzhi Gao ◽  
Yu Fan ◽  
Xiang Xie
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Chinese Han Population ◽  
Gastric Cancer Risk ◽  
Chinese Han ◽  
Han Population

Constitutive telomere length and gastric cancer risk: Case-control analysis in Chinese Han population

2009 ◽  
Vol 100 (7) ◽  
pp. 1300-1305 ◽  
Author(s):  
Xiaonan Liu ◽  
Guoqiang Bao ◽  
Tingting Huo ◽  
Zizhong Wang ◽  
Xianli He ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Telomere Length ◽  
Case Control ◽  
Chinese Han Population ◽  
Control Analysis ◽  
Gastric Cancer Risk ◽  
Chinese Han ◽  
Han Population ◽  
Case Control Analysis
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