scholarly journals Alkaline Phosphatase-To-Albumin Ratio as a Prognostic Indicator in Pancreatic Ductal Adenocarcinoma after Curative Resection

2017 ◽  
Vol 8 (16) ◽  
pp. 3362-3370 ◽  
Author(s):  
Ning Pu ◽  
Shanshan Gao ◽  
Yadong Xu ◽  
Guochao Zhao ◽  
Yang Lv ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Curative Resection ◽  
Prognostic Indicator ◽  
Ductal Adenocarcinoma ◽  
Albumin Ratio

scholarly journals Albumin-to-alkaline phosphatase ratio serves as a prognostic indicator in unresectable pancreatic ductal adenocarcinoma: a propensity score matching analysis

2020 ◽  
Author(s):  
Ke Zhang ◽  
Shu Dong ◽  
Yan Hua Jing ◽  
Hui Feng Gao ◽  
Lian Yu Chen ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Propensity Score ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Propensity Score Matching ◽  
Prognostic Model ◽  
Information Criterion ◽  
Prognostic Indicator ◽  
Prediction Performance ◽  
Ductal Adenocarcinoma ◽  
Entire Cohort

Abstract Background Recent evidence suggests that albumin-to-Alkaline Phosphatase Ratio (AAPR) functions as a novel prognostic marker in several malignancies. However, whether it can predict the prognosis of unresectable pancreatic ductal adenocarcinoma (PDAC) remains unclear. Herein, we seek to investigate this possibility by a propensity score matching (PSM) analysis.Methods This was a retrospective cohort study in which 419 patients diagnosed with unresectable PDAC and receiving chemotherapy were recruited. Patients were stratified based on the cutoff value of AAPR. The PSM analysis was performed to identify 156 well-balanced patients in each group for overall survival (OS) comparison and subgroup analysis. Univariate and multivariate analyses were carried out to examine the potential of AAPR to indicate the prognosis of unresectable PDAC. The prediction performance of conventional model and combined model including AAPR was compared using the Akaike Information Criterion (AIC) and concordance index (C-index).Results We identified an AAPR of 0.4 to be the optimal cutoff for OS prediction. Patients with AAPR≤0.4 had significantly shorter OS compared with patients with AAPR>0.4 (6.4 versus 9.3 months; P<0.001). Based on the PSM cohort and entire cohort, multivariate Cox analysis revealed that high pretreatment for AAPR was an independent marker predicting favorable survival in unresectable PDAC (hazard ratio, 0.556; 95% confidence interval, 0.408 to 0.757; P<0.001). Significant differences in OS were observed in all subgroups except for the group of patients age≤60. Combined prognostic model including AAPR had lower AIC and higher C-index than conventional prognostic model.Conclusions Pretreatment AAPR servers as an independent prognostic indicator for patients with unresectable PDAC. Inclusion of AAPR improved the prediction performance of conventional prognostic model, potentially helping clinicians to identify patients at high risk and guide individualized treatment.

scholarly journals Albumin-to-alkaline phosphatase ratio serves as a prognostic indicator in unresectable pancreatic ductal adenocarcinoma: a propensity score matching analysis

2020 ◽  
Author(s):  
Ke Zhang ◽  
Shu Dong ◽  
Yan-Hua Jing ◽  
Hui-Feng Gao ◽  
Lian-Yu Chen ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Propensity Score ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Propensity Score Matching ◽  
Prognostic Indicator ◽  
Ductal Adenocarcinoma ◽  
Entire Cohort ◽  
Propensity Score Matching Analysis ◽  
Cox Analysis ◽  
Independent Marker

Abstract Background Recent evidence suggests that albumin-to-Alkaline Phosphatase Ratio (AAPR) functions as a novel prognostic marker in several malignancies. However, whether it can predict the prognosis of unresectable pancreatic ductal adenocarcinoma (PDAC) remains unclear. Herein, we seek to explore this possibility by a propensity score matching (PSM) analysis. Methods This was a retrospective design in which 419 patients diagnosed with unresectable PDAC and receiving chemotherapy were recruited. Patients were stratified based on the cutoff value of AAPR. The PSM analysis was used to identify 156 well-balanced patients in each group for overall survival (OS) comparison and subgroup analysis. Univariate and multivariate analyses were carried out to examine the potential of AAPR to indicate the prognosis of unresectable PDAC. Results We identified an AAPR of 0.4 to be the optimal cutoff for OS prediction. Patients with AAPR≤0.4 had significantly shorter OS compared with patients with AAPR>0.4 (6.4 versus 9.3 months; P<0.001). Based on the PSM cohort and entire cohort, multivariate Cox analysis revealed that high pretreatment for AAPR was an independent marker predicting favorable survival in unresectable PDAC (hazard ratio, 0.556; 95% confidence interval, 0.408 to 0.757; P<0.001). Significant differences in OS were observed in all subgroups except for the group of patients age≤60. Conclusions Pretreatment AAPR is an effective marker that predicts outcomes of patients with unresectable PDAC, potentially helping clinicians to identify patients at high risk and guide individualized treatment.

Prognostic Significance of Plasma Fibrinogen/Serum Albumin Ratio in the Postoperative Outcome of Pancreatic Ductal Adenocarcinoma

2020 ◽  
Vol 40 (12) ◽  
pp. 7017-7023
Author(s):  
KOICHI TOMITA ◽  
SHIGETO OCHIAI ◽  
TAKAHIRO GUNJI ◽  
KOSUKE HIKITA ◽  
TOSHIMICHI KOBAYASHI ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Prognostic Significance ◽  
Postoperative Outcome ◽  
Plasma Fibrinogen ◽  
Ductal Adenocarcinoma ◽  
Albumin Ratio

Patterns of recurrence after curative resection of pancreatic ductal adenocarcinoma

2009 ◽  
Vol 35 (6) ◽  
pp. 600-604 ◽  
Author(s):  
A. Van den broeck ◽  
G. Sergeant ◽  
N. Ectors ◽  
W. Van Steenbergen ◽  
R. Aerts ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Curative Resection ◽  
Ductal Adenocarcinoma ◽  
Patterns Of Recurrence

Impact of the Controlling Nutritional Status Score on the Prognosis After Curative Resection of Pancreatic Ductal Adenocarcinoma

Pancreas ◽  
2018 ◽  
Vol 47 (7) ◽  
pp. 823-829 ◽  
Author(s):  
Yoshiyasu Kato ◽  
Suguru Yamada ◽  
Masaya Suenaga ◽  
Hideki Takami ◽  
Yukiko Niwa ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Curative Resection ◽  
Ductal Adenocarcinoma ◽  
Status Score

Clinical usefulness of postoperative C-reactive protein/albumin ratio in pancreatic ductal adenocarcinoma

2018 ◽  
Vol 216 (1) ◽  
pp. 111-115 ◽  
Author(s):  
Kota Arima ◽  
Yo-ichi Yamashita ◽  
Daisuke Hashimoto ◽  
Shigeki Nakagawa ◽  
Naoki Umezaki ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Clinical Usefulness ◽  
Ductal Adenocarcinoma ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Reactive Protein

scholarly journals Fibroblasts as a Biological Marker for Curative Resection in Pancreatic Ductal Adenocarcinoma

2020 ◽  
Vol 21 (11) ◽  
pp. 3890 ◽  
Author(s):  
Eriko Katsuta ◽  
Omar M. Rashid ◽  
Kazuaki Takabe
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Cancer Cell ◽  
Cancer Biology ◽  
Curative Resection ◽  
Biological Marker ◽  
Ductal Adenocarcinoma ◽  
R0 Resection ◽  
Small Subset ◽  
Inverse Association ◽  
Anti Cancer

Achievement of microscopic tumor clearance (R0) after pancreatic ductal adenocarcinoma (PDAC) surgery is determined by cancer biology rather than operative technique. Fibroblasts are known to play pro-cancer roles; however, a small subset was recently found to play anti-cancer roles. Therefore, we hypothesized that intratumor fibroblasts contribute to curative resection and a better survival of PDAC. Utilizing a large, publicly available PDAC cohort, we found that fibroblast composition was associated with R0 curative resection. A high amount of fibroblasts in PDACs was significantly associated with a higher amount of mature vessels, but not with blood angiogenesis. A high amount of fibroblasts was also associated with a higher infiltration of anti-cancer immune cells, such as CD8+ T-cells and dendritic cells, together with higher inflammatory signaling, including IL2/STAT5 and IL6/JAK/STAT3 signaling. Further, the fibroblast composition was inversely associated with cancer cell composition in the bulk tumor, along with an inverse association with proliferative characteristics, such as MYC signaling and glycolysis. The patients with high-fibroblast PDACs showed an improved prognosis. In conclusion, we found that PDACs with high fibroblasts were associated with a higher R0 resection rate, resulting in a better prognosis. These findings may be due to less aggressive biology with a higher vascularity and anti-cancer immunity, and a low cancer cell component.

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