scholarly journals Additional induction chemotherapy to concurrent chemotherapy and intensity-modulated radiotherapy with or without nimotuzumab in first-line treatment for locoregionally advanced nasopharyngeal carcinoma: a propensity score matched analysis

2018 ◽  
Vol 9 (3) ◽  
pp. 594-603 ◽  
Author(s):  
Fangzheng Wang ◽  
Quanquan Sun ◽  
Chuner Jiang ◽  
Tongxin Liu ◽  
Aizawa Rihito ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Propensity Score ◽  
Induction Chemotherapy ◽  
Intensity Modulated Radiotherapy ◽  
Concurrent Chemotherapy ◽  
Line Treatment ◽  
First Line ◽  
Intensity Modulated ◽  
First Line Treatment

scholarly journals Patterns of regional lymph node failure of locally advanced hypopharynx squamous cell carcinoma after first-line treatment with surgery and/or intensity-modulated radiotherapy

2019 ◽  
Author(s):  
Dongqing Wang ◽  
Shui Yu ◽  
Liming Zhai ◽  
Jin Xu ◽  
Baosheng Li
Keyword(s):  
Lymph Node ◽  
Regional Lymph Node ◽  
Locally Advanced ◽  
Intensity Modulated Radiotherapy ◽  
Line Treatment ◽  
First Line ◽  
Node Failure ◽  
Intensity Modulated ◽  
Level Ii ◽  
First Line Treatment

Abstract Purpose : To identify the spatial patterns of regional lymph node failure of locally advanced hypopharynx squamous cell carcinoma (SCC) after first-line treatment with surgery and/or intensity-modulated radiotherapy (IMRT). Methods : We retrospectively analyzed 123 patients of the hypopharynx SCC consecutively treated with radical surgical resection and/or IMRT. Results : Median PFS were 13 months (95% CI 6.4-19.6 months), and 11 months (95% CI 9.1-12.9 months) for patients receiving surgery and IMRT, respectively. The cervical lymph node failure was accounted for 32.5% of patients, with involved ipsilateral neck level II in 22 patients (55.0%), III in 12 patients (30.0%), IV in 2 patients (5%), VIb and VII both in 6 patients (5.0%), furthermore, involved contralateral neck level II in 7 patients (17.5%), III in 3 patients (7.5%). The commonly failure levels were the II (15.2%), III (8.7%), VIb (8.7%), and VII (10.9%) for surgery. The lymph node recurrence and persistent disease at levels II (24.7%) and III (13.0%) remained the major cause of failure following curative intent of IMRT. Conclusions: Whatever the treatment modality, levels II and III were most commonly failure regions. Because of high rate of node failure of level VIb and VII for patients receiving surgery, post-operative radiation should included of these territories in locally advanced hypopharynx SCC.

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