scholarly journals Immune Cell Population in Ovarian Tumor Microenvironment

2017 ◽  
Vol 8 (15) ◽  
pp. 2915-2923 ◽  
Author(s):  
Dong Li Cai ◽  
Li-Ping Jin
Keyword(s):  
Tumor Microenvironment ◽  
Cell Population ◽  
Ovarian Tumor ◽  
Immune Cell ◽  
Immune Cell Population

scholarly journals P062 Differences in immune cell population subsets in inflammatory bowel disease patients under anti-TNF treatment

2019 ◽  
Vol 13 (Supplement_1) ◽  
pp. S117-S117
Author(s):  
S Notararigo ◽  
J E Viñuela Roldán ◽  
M Abanades-Tercero ◽  
J E Dominguez-Munoz ◽  
M Barreiro-de Acosta
Keyword(s):  
Inflammatory Bowel Disease ◽  
Cell Population ◽  
Bowel Disease ◽  
Immune Cell ◽  
Immune Cell Population ◽  
Inflammatory Bowel

scholarly journals 110 Characterizing the immune cell population in the human fetal membrane

2021 ◽  
Vol 224 (2) ◽  
pp. S76-S77
Author(s):  
Sara Jacobs ◽  
Samantha Sheller-Miller ◽  
Lauren Richardson ◽  
Rheanna Urrabaz-Garza ◽  
Enkhtuya Radnaa ◽  
...  
Keyword(s):  
Cell Population ◽  
Immune Cell ◽  
Fetal Membrane ◽  
Immune Cell Population

Abstract 003: Cholinergic Expansion of an Inflammatory Macrophage Population in the Pre-Hypertensive Spontaneously Hypertensive Rat

Hypertension ◽  
2014 ◽  
Vol 64 (suppl_1) ◽  
Author(s):  
Sailesh Harwani ◽  
Mark W Chapleau ◽  
Fayyaz Sutterwala ◽  
Zuhair Ballas ◽  
David Meyerholz ◽  
...  
Keyword(s):  
Cell Population ◽  
Immune Cell ◽  
Spontaneously Hypertensive Rat ◽  
Isolated Cells ◽  
Immune Cell Population ◽  
Macrophage Population ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat ◽  
Wistar Kyoto ◽  
Cholinergic Activation

Our laboratory previously identified an abnormally elevated CD161a+ immune cell population in splenocytes of the pre-hypertensive Spontaneously Hypertensive Rat (SHR) that was abnormally expanded following cholinergic activation with nicotine . In the present study, we tested the hypothesis that the expanded CD161a+ cell population represents an activated monocyte/macrophage population and are present in the bone marrow (BM). We isolated cells from the spleen and BM of pre-hypertensive (4-5 week old) SHR (n=3) and age-matched normotensive Wistar Kyoto (WKY, n=3) rats. Isolated cells were stained with a fluorochrome conjugated anti-rat CD161a monoclonal antibody and analyzed by flow cytometry. CD161a+ cells were more prevalent in splenocytes and BM of the pre-hypertensive SHR, compared to WKY (8.7 ± 1.4% vs 1.2 ± 0.6% and 12.6 ± 1.8% vs 1.7 ± 0.8%, respectively, p<0.001). BM cells and splenocytes were cultured for 36-48 hours in the presence or absence of nicotine (10μM) and then stained with fluorochrome conjugated anti-rat CD161a and CD68 antibodies. CD68 is a well accepted pan-macrophage marker that is up-regulated on activated monocytes/macrophages. The CD161+/CD68+ macrophages were comparable between the WKY and SHR in freshly isolated cells from the spleen (0.3 ± 0.2% vs 0.9 ± 0.5%, respectively) and BM (0.6 ± 0.4% vs 0.7 ± 0.2%, respectively). However, nicotine strongly expanded the CD161a+/CD68+ macrophage population in the BM of the SHR (1.1 ± 0.15% to 11.9 ± 3.45%, p<0.001) and WKY (1.7 ± 0.17% to 11.0 ± 1.9%, p<0.001). In contrast, the response of splenocytes to nicotine was strong in SHR (1.8 ± 0.40% to 10.7 ± 1.1%, p<0.001), but not significant in WKY (1.9 ± 0.4% to 3.1 ± 0.6%, p>0.05). Nicotine had no effect on the CD161a+/CD68- cell population in either splenocytes or BM cells of the SHR or WKY. Thus, an activated monocyte/macrophage population (CD161a+/CD68+) is expanded by cholinergic activation in both the BM and spleen of SHR, but only in the BM and not spleen of the WKY. Since, the pro-inflammatory nicotinic response present in the BM of the WKY is abrogated in the peripheral spleen, we conclude that the retention of this response in the SHR may contribute to the development of hypertension.

Abstract A57: βhCG regulates immune cell population in BRCA1 mutated breast cancers

2020 ◽  
Author(s):  
Geetu Rose Varghese ◽  
Vishnu Sunil Jaikumar ◽  
Arathi Rajan ◽  
Neetha Rajan Latha ◽  
Dipyaman Patra ◽  
...  
Keyword(s):  
Cell Population ◽  
Immune Cell ◽  
Breast Cancers ◽  
Immune Cell Population

scholarly journals IMMU-20. CHARACTERIZING THE IMMUNE LANDSCAPE OF PD-1/PD-L1 IN BRAIN TUMOR IMMUNE CELL POPULATION USING CyTOF MASS CyTOMETRY

2017 ◽  
Vol 19 (suppl_6) ◽  
pp. vi116-vi116
Author(s):  
Alexander Lee ◽  
Tom Davidson ◽  
Mildred Galvez ◽  
David Nathanson ◽  
Anthony Wang ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Cell Population ◽  
Immune Cell ◽  
Mass Cytometry ◽  
Immune Cell Population

scholarly journals In situ production of innate immune cells in murine white adipose tissue

Blood ◽  
2012 ◽  
Vol 120 (25) ◽  
pp. 4952-4962 ◽  
Author(s):  
Sandrine Poglio ◽  
Fabienne De Toni ◽  
Daniel Lewandowski ◽  
Adeline Minot ◽  
Emmanuelle Arnaud ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Cell Population ◽  
White Adipose Tissue ◽  
Immune Cells ◽  
Immune Cell ◽  
Innate Immune ◽  
Immune Cell Population ◽  
Hematopoietic Stem ◽  
Hematopoietic Activity

Abstract White adipose tissue (WAT) is the focus of new interest because of the presence of an abundant and complex immune cell population that is involved in key pathologies such as metabolic syndrome. Based on in vivo reconstitution assays, it is thought that these immune cells are derived from the bone marrow (BM). However, previous studies have shown that WAT exhibits specific hematopoietic activity exerted by an unknown subpopulation of cells. In the present study, we prospectively isolated a peculiar hematopoietic stem/progenitor cell population from murine WAT. The cells are phenotypically similar to BM hematopoietic stem cells and are able to differentiate into both myeloid and lymphoid lineages in vitro. In competitive repopulation assays in vivo, they reconstituted the innate immune compartment in WAT preferentially and more efficiently than BM cells, but did not reconstitute hematopoietic organs. They were also able to give rise to multilineage engraftment in both secondary recipients and in utero transplantation. Therefore, we propose that WAT hematopoietic cells constitute a population of immature cells that are able to renew innate immune cell populations. Considering the amount of WAT in adults, our results suggest that WAT hematopoietic activity controls WAT inflammatory processes and also supports innate immune responses in other organs.

scholarly journals Microglia in Health and Disease: A Unique Immune Cell Population

2018 ◽  
Vol 9 ◽  
Author(s):  
Alessandro Michelucci ◽  
Michel Mittelbronn ◽  
Diego Gomez-Nicola
Keyword(s):  
Cell Population ◽  
Immune Cell ◽  
Immune Cell Population ◽  
Health And Disease

scholarly journals Preoperative Neutrophil-Lymphocyte and Lymphocyte-Monocyte Ratios Reflect Immune Cell Population Rearrangement in Resectable Pancreatic Cancer

2016 ◽  
Vol 24 (3) ◽  
pp. 808-815 ◽  
Author(s):  
Marek Sierzega ◽  
Marzena Lenart ◽  
Magdalena Rutkowska ◽  
Marta Surman ◽  
Bozenna Mytar ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Population ◽  
Immune Cell ◽  
Resectable Pancreatic Cancer ◽  
Immune Cell Population
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