scholarly journals Interferon-α Promotes the Expression of Cancer Stem Cell Markers in Oral Squamous Cell Carcinoma

2017 ◽  
Vol 8 (12) ◽  
pp. 2384-2393 ◽  
Author(s):  
Hailong Ma ◽  
Shufang Jin ◽  
Wenyi Yang ◽  
Zhuowei Tian ◽  
Shuli Liu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Oral Squamous Cell Carcinoma ◽  
Cancer Stem Cell ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Interferon Α ◽  
Stem Cell Markers ◽  
Cell Markers ◽  
Cancer Stem Cell Markers

scholarly journals Cancer stem cell markers in patterning differentiation and in prognosis of oral squamous cell carcinoma

Tumor Biology ◽  
2017 ◽  
Vol 39 (6) ◽  
pp. 101042831770365 ◽  
Author(s):  
Simple Mohanta ◽  
Gangotri Siddappa ◽  
Sindhu Govindan Valiyaveedan ◽  
Ravindra Dodda Thimmasandra Ramanjanappa ◽  
Debashish Das ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Oral Squamous Cell Carcinoma ◽  
Cancer Stem Cell ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Stem Cell Markers ◽  
Cell Markers ◽  
Cancer Stem Cell Markers

scholarly journals Prognostic Relevance of CD4+, CD8+ and FOXP3+ TILs in Oral Squamous Cell Carcinoma and Correlations with PD-L1 and Cancer Stem Cell Markers

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 653
Author(s):  
Paloma Lequerica-Fernández ◽  
Julián Suárez-Canto ◽  
Tania Rodriguez-Santamarta ◽  
Juan Pablo Rodrigo ◽  
Faustino Julián Suárez-Sánchez ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Prognostic Factor ◽  
Oral Squamous Cell Carcinoma ◽  
Cancer Stem Cell ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Independent Prognostic Factor ◽  
Stem Cell Markers ◽  
Cancer Stem Cell Markers

This study investigates the relevance of tumor-infiltrating lymphocytes (TILs) in oral squamous cell carcinoma (OSCC). Immunohistochemical analysis of stromal/tumoral CD4+, CD8+ and FOXP3+ TILs is performed in 125 OSCC patients. Potential relationships with the expression of tumoral PD-L1 and cancer stem cell (CSC) markers (NANOG, SOX2, OCT4, Nestin and Podoplanin (PDPN)) are assessed. CD4+ and CD8+ TILs are significantly associated with smoking and alcohol habits. CD4+ and CD8+ TILs show an inverse relationship with NANOG and SOX2 expression, and FOXP3+ TILs is significantly correlated with Nestin and PDPN expression. High infiltration of CD4+ and CD8+ TILs and a high tumoral CD8+/FOXP3+ ratio are significantly associated with tumors harboring positive PD-L1 expression. Infiltration of stromal/tumoral FOXP3+ TILs and a low stromal CD8+/FOXP3+ ratio are significantly associated with better disease-specific survival. Multivariate analysis reveals that the stromal CD8+/FOXP3+ TILs ratio is a significant independent prognostic factor. Regarding OSCC patient survival, the CD8+/FOXP3+ TILs ratio is an independent prognostic factor. TILs may act as biomarkers and potential therapeutic targets for OSCC.

scholarly journals Combined prognostic value of the cancer stem cell markers CD47 and CD133 in esophageal squamous cell carcinoma

2019 ◽  
Vol 8 (3) ◽  
pp. 1315-1325 ◽  
Author(s):  
Jian‐Hua Wang ◽  
Shu‐Ting Huang ◽  
Lan Zhang ◽  
Zi‐Gang Liu ◽  
Rong‐Xin Liang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cancer Stem Cell ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Stem Cell Markers ◽  
Cell Markers ◽  
Cancer Stem Cell Markers
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