scholarly journals Down-regulation of RPS9 Inhibits Osteosarcoma Cell Growth through Inactivation of MAPK Signaling Pathway

2017 ◽  
Vol 8 (14) ◽  
pp. 2720-2728 ◽  
Author(s):  
Dong-dong Cheng ◽  
Bin Zhu ◽  
Shi-jie Li ◽  
Ting Yuan ◽  
Qing-cheng Yang ◽  
...  
Keyword(s):  
Cell Growth ◽  
Signaling Pathway ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Osteosarcoma Cell ◽  
Down Regulation

Glutathione S-transferase omega 2 regulates cell growth and the expression of E-cadherin via post-transcriptional down-regulation of β-catenin in human esophageal squamous cells

2019 ◽  
Vol 41 (7) ◽  
pp. 875-886
Author(s):  
Masayoshi Terayama ◽  
Kazuhiko Yamada ◽  
Teruki Hagiwara ◽  
Fumika Inazuka ◽  
Takuhito Sezaki ◽  
...  
Keyword(s):  
Cell Growth ◽  
Signaling Pathway ◽  
Cell Lines ◽  
Mapk Signaling ◽  
Membrane Localization ◽  
Esophageal Mucosa ◽  
Glutathione S Transferase ◽  
Down Regulation ◽  
Transfected Cells ◽  
E Cadherin

Abstract Glutathione S-transferase omega 2 (GSTO2), which belongs to the superfamily of GST omega class, lacks any appreciable GST activity. Although GSTO2 exhibits thioltransferase and glutathione dehydrogenase activities, its precise expression and physiological functions are still unclear. In the present study, we found that GSTO2 is exclusively expressed in the basal cell layer in Ki67-negative non-proliferative cells in the human esophageal mucosa. GSTO2 overexpression in esophageal squamous cell carcinoma (ESCC) cell lines inhibited cell growth and colony formation, and GSTO2-transfected cells formed smaller tumors in nude mice compared with mock-transfected cells. Interestingly, GSTO2 induction suppressed the expressions of E-cadherin and β-catenin at the cell–cell contact site. We quantified the phosphorylation levels of key proteins of MAPK signaling pathway and identified phosphorylation of p38. Additionally, HSP27, a downstream molecule of p38, was accelerated in GSTO2-transfected cells, unlike in mock-transfected cells. When GSTO2-transfected cells were treated with a p38 inhibitor, the expression of β-catenin and the membrane localization of E-cadherin was recovered. We next examined GSTO2 expression in 61 ESCC tissues using quantitative reverse transcription polymerase chain reaction and immunostaining. The results showed that GSTO2 mRNA and protein were significantly reduced in ESCC compared with normal tissues. When human ESCC cell lines were treated with 5-aza-2′-deoxycytidine, a DNA-methyltransferase inhibitor, GSTO2 transcription was induced, suggesting that aberrant hypermethylation is the cause of the down-regulated expression. Our results indicate that GSTO2 expression inhibits the membrane localization of E-cadherin, probably by modulation of the p38 signaling pathway. Down-regulation of GSTO2 by DNA hypermethylation contributes to the growth and progression of ESCC.

scholarly journals Arsenic trioxide inhibits osteosarcoma cell invasiveness via MAPK signaling pathway

2010 ◽  
Vol 10 (3) ◽  
pp. 251-257 ◽  
Author(s):  
Ren Tingting ◽  
Guo Wei ◽  
Peng Changliang ◽  
Lu Xinchang ◽  
Yang Yi
Keyword(s):  
Arsenic Trioxide ◽  
Signaling Pathway ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Osteosarcoma Cell ◽  
Cell Invasiveness

scholarly journals Aloesin Suppresses Cell Growth and Metastasis in Ovarian Cancer SKOV3 Cells through the Inhibition of the MAPK Signaling Pathway

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Li-qian Zhang ◽  
Rong-wei Lv ◽  
Xiang-dong Qu ◽  
Xian-jun Chen ◽  
Hong-sheng Lu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Growth ◽  
Signaling Pathway ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Mitogen Activated Protein Kinase ◽  
Migration And Invasion ◽  
Therapeutic Drug ◽  
Dependent Manner ◽  
Skov3 Cells

Aloesin is an active constituent of the herb aloe vera and plays a crucial role in anti-inflammatory activity, ultraviolet protection, and antibacterium. We investigated the role and possible mechanisms of aloesin in the cell growth and metastasis of ovarian cancer. It was found that aloesin inhibited cell viability and cell clonality in a dose-dependent manner. It arrests the cell cycle at the S-phase and induced apoptosis in SKOV3 cells. In an in vivo experiment, it was observed that aloesin inhibited tumor growth. Moreover, it inhibited migration and invasion of cancer in SKOV3 cells. Interestingly, members from the mitogen-activated protein kinase (MAPK) signaling family became less phosphorylated as the aloesin dose increased. This suggests that aloesin exerts its anticancer effect through the MAPK signaling pathway. Our data also highlights the possibility of using aloesin as a novel therapeutic drug for ovarian cancer treatment.

scholarly journals miR-433 inhibits breast cancer cell growth via the MAPK signaling pathway by targeting Rap1a

2018 ◽  
Vol 14 (6) ◽  
pp. 622-632 ◽  
Author(s):  
Tao Zhang ◽  
Kangfeng Jiang ◽  
Xinying Zhu ◽  
Gan Zhao ◽  
Haichong Wu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth

scholarly journals Down-regulation of HIV-1 infection by inhibition of the MAPK signaling pathway

2011 ◽  
Vol 26 (2) ◽  
pp. 114-122 ◽  
Author(s):  
Jian Gong ◽  
Xi-hui Shen ◽  
Chao Chen ◽  
Hui Qiu ◽  
Rong-ge Yang
Keyword(s):  
Signaling Pathway ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Down Regulation ◽  
Hiv 1

scholarly journals Regulation of mPGES‑1 composition and cell growth via the MAPK signaling pathway in jurkat cells

2018 ◽  
Author(s):  
Yi‑Qing Li ◽  
Jiao‑Ting Chen ◽  
Song‑Mei Yin ◽  
Da‑Nian Nie ◽  
Zhi‑Yuan He ◽  
...  
Keyword(s):  
Cell Growth ◽  
Signaling Pathway ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Jurkat Cells
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