scholarly journals Combined Detection of Plasma ZIC1, HOXD10 and RUNX3 Methylation is a Promising Strategy for Early Detection of Gastric Cancer and Precancerous Lesions

2017 ◽  
Vol 8 (6) ◽  
pp. 1038-1044 ◽  
Author(s):  
Zhenghua Lin ◽  
Mengzhao Luo ◽  
Xueqing Chen ◽  
Xingkang He ◽  
Yun Qian ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Detection ◽  
Precancerous Lesions ◽  
Promising Strategy ◽  
Combined Detection

scholarly journals HypermethylatedFAM5CandMYLKin Serum as Diagnosis and Pre-Warning Markers for Gastric Cancer

2012 ◽  
Vol 32 (3) ◽  
pp. 195-202 ◽  
Author(s):  
Lu Chen ◽  
Liping Su ◽  
Jianfang Li ◽  
Yanan Zheng ◽  
Beiqin Yu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Candidate Genes ◽  
Early Stage ◽  
Precancerous Lesions ◽  
Single Gene ◽  
High Specificity ◽  
Serum Samples ◽  
Promoter Regions ◽  
Gastric Cancer Cell Lines ◽  
Combined Detection

Most cases of gastric cancer (GC) are not diagnosed at early stage which can be curable, so it is necessary to identify effective biomarkers for its diagnosis and pre-warning. We have used methylated DNA immunoprecipitation (MeDIP) to identify genes that are frequently methylated in gastric cancer cell lines. Promoter regions hypermethylation of candidate genes were tested by methylation-specific polymerase chain reaction (MSP) in serum samples, including GC (n= 58), gastric precancerous lesions (GPL,n= 46), and normal controls (NC,n= 30). Eighty two hypermethylated genes were acquired by array analysis and 5 genes (BCAS4, CHRM2, FAM5C, PRACandMYLK) were selected as the candidate genes. Three genes (CHRM2, FAM5CandMYLK) were further confirmed to show methylation rates increased with progression from NC to GPL, then to GC. There was obvious decrease in detection ofFAM5CandMYLKhypermethylation, but notCHRM2, from preoperative to postoperative evaluation (P< 0.001). Combined detection of FAM5C and MYLK hypermethylation had a higher sensitivity in GC diagnosis (77.6%,45/58) and pre-warning (30.4%,14/46) than one single gene detection and also had a high specificity of 90%. The combined hypermethylated status ofFAM5CandMYLKcorrelated with tumor size (P< 0.001), tumor invasion depth (P= 0.001) and tumor-node-metastasis (TNM) stage (P= 0.003). HypermethylatedFAM5CandMYLKcan be used as potential biomarkers for diagnosis and pre-warning of GC.

Effect of periodic endoscopy for gastric cancer on early detection and improving survival

2001 ◽  
Vol 120 (5) ◽  
pp. A606-A606
Author(s):  
Y MORII ◽  
T YOSHIDA ◽  
T MATSUMATA ◽  
T ARITA ◽  
K SHIMODA ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Detection

scholarly journals Gankyrin Drives Malignant Transformation of Gastric Cancer and Alleviates Oxidative Stress via mTORC1 Activation

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Bo Huang ◽  
Weiyang Cai ◽  
Qian Wang ◽  
Feng Liu ◽  
Ming Xu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gastric Cancer ◽  
Malignant Transformation ◽  
Precancerous Lesions ◽  
Poor Overall Survival ◽  
Epithelial Tumor ◽  
Pathway Activation ◽  
Mtorc1 Pathway ◽  
Malignant Epithelial Tumor ◽  
Mtorc1 Activation

Gastric cancer, as a malignant epithelial tumor, is a major health threat leading to poor overall survival and death. It is usually diagnosed at an advanced stage due to asymptomatic or only nonspecific early symptoms. The present study demonstrated that gankyrin contributes to the early malignant transformation of gastric cancer and can be selected to predict the risk of gastric cancer in those patients harboring the precancerous lesions (dysplasia and intestinal metaplasia). In addition, a new insight into gastric cancer was provided, which stated that gankyrin alleviates oxidative stress via mTORC1 pathway activation. It can potentiate the mTORC1 by PGK1-AKT signaling that promotes the tumor process, and this phenomenon is not completely consistent with the previous report describing colorectal cancer.

scholarly journals Early Detection is Important to Reduce the Economic Burden of Gastric Cancer

2018 ◽  
Vol 18 (1) ◽  
pp. 82 ◽  
Author(s):  
Jie-Hyun Kim ◽  
Sung Soo Kim ◽  
Jeong Hoon Lee ◽  
Da Hyun Jung ◽  
Dae Young Cheung ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Detection ◽  
Economic Burden

Tu1308 Methylation Analysis of Gastric Juice-derived Exosomal DNA is Useful for Early Detection of Gastric Cancer

2016 ◽  
Vol 150 (4) ◽  
pp. S871
Author(s):  
Hiroyuki Yamamoto ◽  
Yoshihito Yoshida ◽  
Ryo Morita ◽  
Ritsuko Oikawa ◽  
Tadateru Maehata ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Detection ◽  
Gastric Juice ◽  
Methylation Analysis

scholarly journals Identification of Early Diagnostic and Prognostic Biomarkers via WGCNA in Stomach Adenocarcinoma

2021 ◽  
Vol 11 ◽  
Author(s):  
Ruoyue Tan ◽  
Guanghui Zhang ◽  
Ruochen Liu ◽  
Jianbing Hou ◽  
Zhen Dong ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Extracellular Matrix ◽  
Early Detection ◽  
Early Stage ◽  
Gene Set Enrichment Analysis ◽  
Stage I ◽  
Tyrosine Kinase Receptor ◽  
Stomach Adenocarcinoma ◽  
Early Diagnostic ◽  
Potential Biomarkers

Stomach adenocarcinoma (STAD) is a leading cause of cancer deaths, and the outcome of the patients remains dismal for the lack of effective biomarkers of early detection. Recent studies have elucidated the landscape of genomic alterations of gastric cancer and reveal some biomarkers of advanced-stage gastric cancer, however, information about early-stage biomarkers is limited. Here, we adopt Weighted Gene Co-expression Network Analysis (WGCNA) to screen potential biomarkers for early-stage STAD using RNA-Seq and clinical data from TCGA database. We find six gene clusters (or modules) are significantly correlated with the stage-I STADs. Among these, five hub genes, i.e., MS4A1, THBS2, VCAN, PDGFRB, and KCNA3 are identified and significantly de-regulated in the stage-I STADs compared with the normal stomach gland tissues, which suggests they can serve as potential early diagnostic biomarkers. Moreover, we show that high expression of VCAN and PDGFRB is associated with poor prognosis of STAD. VCAN encodes a large chondroitin sulfate proteoglycan that is the main component of the extracellular matrix, and PDGFRB encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor (PDGF) family. Consistently, Gene Ontology (GO) analysis of differentially expressed genes in the STADs indicates terms associated with extracellular matrix and receptor ligand activity are significantly enriched. Protein-protein network interaction analysis (PPI) and Gene Set Enrichment Analysis (GSEA) further support the core role of VCAN and PDGFRB in the tumorigenesis. Collectively, our study identifies the potential biomarkers for early detection and prognosis of STAD.

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