scholarly journals Aided Diagnosis of Hepatocellular Carcinoma Using Serum Fucosylated Haptoglobin Ratios

2017 ◽  
Vol 8 (5) ◽  
pp. 887-893 ◽  
Author(s):  
Shuxin Shang ◽  
Wei Li ◽  
Xue Qin ◽  
Shu Zhang ◽  
Yinkun Liu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Aided Diagnosis ◽  
Fucosylated Haptoglobin

scholarly journals Evaluation of Fucosylated Haptoglobin as a Diagnostic Biomarker for Hepatocellular Carcinoma in Egypt

2019 ◽  
Vol 9 (1) ◽  
pp. 31-37
Author(s):  
Nahla M. Shalably ◽  
Rehab Badawi ◽  
Nehad Hawash ◽  
Sherief Abd-Elsalam ◽  
Walaa Elkhalawany ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Predictive Value ◽  
Percutaneous Biopsy ◽  
Staging System ◽  
Control Group ◽  
Diagnostic Biomarker ◽  
Group Iii ◽  
Group I ◽  
Patients At Risk ◽  
Fucosylated Haptoglobin

Background: Most Hepatocellular Carcinomas (HCCs) are diagnosed at an advanced stage. Therefore, there is citation-type an urgent need for better methods of detection and surveillance of patients at risk of HCC. Alpha-fetoprotein (AFP) has a suboptimal diagnostic performance for HCC surveillance, so novel and reliable diagnostic biomarkers are required. Objective: The aim of this work is to evaluate fucosylated haptoglobin as a diagnostic biomarker for hepatocellular carcinoma in Egyptian patients. Materials and Methods: This case-control study was carried out on 60 patients classified into 3 groups (20 patients on each); group I (HCC group), group II (Cirrhotic group) and group III (Control group). Diagnosis of liver cirrhosis was done by clinical, biochemical and ultrasound (US), whereas the diagnosis of HCC was done by percutaneous biopsy or radiological (by US and triphasic Computerized Tomography (CT) based on the guidelines of the American-Association for the Study of Liver Diseases. HCC stage was clinically defined according to the Barcelona Clinic Liver Cancer (BCLC) staging system. AFP & fucosylated haptoglobin levels were estimated in all groups. Results: There was a statistically significant positive correlation between serum fucosylated haptoglobin and tumor size in the HCC group. Serum fucosylated haptoglobin (at 116 U/ ml) showed sensitivity 80%, specificity 65%, positive predictive value 53% and negative predictive value 87% with AUC 0.786. Combination of serum fucosylated haptoglobin and serum AFP at (200 ng/ ml) increased sensitivity that reached 95%. Conclusion: Serum fucosylated haptoglobin may serve as a novel diagnostic biomarker for the detection of HCC with higher sensitivity than AFP.

Computer-aided diagnosis of cirrhosis and hepatocellular carcinoma using multi-phase abdomen CT

2019 ◽  
Vol 14 (8) ◽  
pp. 1341-1352 ◽  
Author(s):  
Akash Nayak ◽  
Esha Baidya Kayal ◽  
Manish Arya ◽  
Jayanth Culli ◽  
Sonal Krishan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Computer Aided Diagnosis ◽  
Abdomen Ct ◽  
Computer Aided ◽  
Multi Phase ◽  
Aided Diagnosis

Multimodality treatment of hepatocellular carcinoma

1998 ◽  
Vol 13 (11-s4) ◽  
pp. S315-S319 ◽  
Author(s):  
ZHAO-YOU TANG ◽  
XIN-DA ZHOU ◽  
ZENG-CHEN MA ◽  
ZHI-QUAN WU ◽  
JIA FAN ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Multimodality Treatment

Hepatocellular carcinoma

1982 ◽  
Vol 118 (1) ◽  
pp. 69-70 ◽  
Author(s):  
A. J. Bennett
Keyword(s):  
Hepatocellular Carcinoma
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