scholarly journals Transcriptional cofactor Mask2 is required for YAP-induced cell growth and migration in bladder cancer cell

2016 ◽  
Vol 7 (14) ◽  
pp. 2132-2138 ◽  
Author(s):  
Liang Dong ◽  
Fan Lin ◽  
Wanjun Wu ◽  
Weiren Huang ◽  
Zhiming Cai
Keyword(s):  
Bladder Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Bladder Cancer Cell ◽  
Cell Growth And Migration ◽  
And Migration

scholarly journals The Inhibitory Effect of Sulforaphane on Bladder Cancer Cell Depends on GSH Depletion-Induced by Nrf2 Translocation

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4919
Author(s):  
Canxia He ◽  
Luigina P. Buongiorno ◽  
Wei Wang ◽  
Jonathan C. Y. Tang ◽  
Natalizia Miceli ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Bladder Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Inhibitory Effect ◽  
Bladder Cancer Cell ◽  
High Dose ◽  
Cell Growth And Migration ◽  
T24 Cells ◽  
And Migration

Sulforaphane (SFN), an isothiocyanate (ITCs) derived from glucosinolate that is found in cruciferous vegetables, has been reported to exert a promising anticancer effect in a substantial amount of scientific research. However, epidemical studies showed inconsistencies between cruciferous vegetable intake and bladder cancer risk. In this study, human bladder cancer T24 cells were used as in vitro model for revealing the inhibitory effect and its potential mechanism of SFN on cell growth. Here, a low dose of SFN (2.5 µM) was shown to promote cell proliferation (5.18–11.84%) and migration in T24 cells, whilst high doses of SFN (>10 µM) inhibited cell growth significantly. The induction effect of SFN on nuclear factor (erythroid-derived 2)-like 2 (Nrf2) expression at both low (2.5 µM) and high dose (10 µM) was characterized by a bell-shaped curve. Nrf2 and glutathione (GSH) might be the underlying mechanism in the effect of SFN on T24 cell growth since Nrf2 siRNA and GSH-depleting agent L-Buthionine-sulfoximine abolished the effect of SFN on cell proliferation. In summary, the inhibitory effect of SFN on bladder cancer cell growth and migration is highly dependent on Nrf2-mediated GSH depletion and following production. These findings suggested that a higher dose of SFN is required for the prevention and treatment of bladder cancer.

Ailanthone inhibits cell growth and migration of cisplatin resistant bladder cancer cells through down-regulation of Nrf2, YAP, and c-Myc expression.

Phytomedicine ◽  
2019 ◽  
Vol 56 ◽  
pp. 156-164 ◽  
Author(s):  
Martina Daga ◽  
Stefania Pizzimenti ◽  
Chiara Dianzani ◽  
Marie Angele Cucci ◽  
Roberta Cavalli ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Down Regulation ◽  
Cell Growth And Migration ◽  
Bladder Cancer Cells ◽  
And Migration

Endogenously formed nitric oxide modulates cell growth in bladder cancer cell lines

Urology ◽  
1999 ◽  
Vol 53 (6) ◽  
pp. 1252-1257 ◽  
Author(s):  
Edward Morcos ◽  
Olof T Jansson ◽  
Jan Adolfsson ◽  
Gunnar Kratz ◽  
N.Peter Wiklund
Keyword(s):  
Nitric Oxide ◽  
Bladder Cancer ◽  
Cell Growth ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Bladder Cancer Cell

scholarly journals Enhanced Inhibition of Bladder Cancer Cell Growth by Simultaneous Knockdown of Antiapoptotic Bcl-xL and Survivin in Combination with Chemotherapy

2013 ◽  
Vol 14 (6) ◽  
pp. 12297-12312 ◽  
Author(s):  
Doreen Kunze ◽  
Kati Erdmann ◽  
Michael Froehner ◽  
Manfred Wirth ◽  
Susanne Fuessel
Keyword(s):  
Bladder Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Bladder Cancer Cell ◽  
Cancer Cell Growth
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