scholarly journals The role of copper transporter ATP7A in platinum-resistance of esophageal squamous cell cancer (ESCC)

2016 ◽  
Vol 7 (14) ◽  
pp. 2085-2092 ◽  
Author(s):  
Zhuang-hua Li ◽  
Rongjie Zheng ◽  
Jing-tang Chen ◽  
Jun Jia ◽  
Miaozhen Qiu
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
Esophageal Squamous Cell Cancer ◽  
Platinum Resistance ◽  
Copper Transporter

The role of salvage surgery for recurrence of esophageal squamous cell cancer

2006 ◽  
Vol 32 (5) ◽  
pp. 544-547 ◽  
Author(s):  
S. Natsugoe ◽  
H. Okumura ◽  
M. Matsumoto ◽  
Y. Uchikado ◽  
T. Setoyama ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Cancer ◽  
Salvage Surgery ◽  
Cell Cancer ◽  
Esophageal Squamous Cell Cancer

547 THE ROLE OF HEAT SHOCK PROTEIN 90 IN HYPOXIA INDUCED ANGIOGENESIS AND EPITHELIAL-MESENCHYMAL TRANSITION OF ESOPHAGEAL SQUAMOUS CELL CANCER

2021 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Ching Tzao ◽  
Chin-Kun Wang
Keyword(s):  
Cell Migration ◽  
Heat Shock ◽  
Squamous Cell ◽  
Epithelial Mesenchymal Transition ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
Esophageal Squamous Cell Cancer ◽  
Mesenchymal Transition ◽  
And Migration

Abstract   Hypoxia is known as an important trigger for the development of metastases in human cancers. Heat shock proteins (Hsps) are up-regulated by cellular stressors including hypoxia. To date, the functional role of Hsps within the hypoxic tumor microenvironment for esophageal squamous cell cancer (ESCC) remains poorly defined. Methods CoCl₂ was used to induce hypoxia in cultured ESCC cells which was confirmed by 2′,7′ –dichlorofluorescin diacetate (DCFDA) assay. 7-Dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a selective Hsp90 inhibitor, was used to treat 2 ESCC cell lines, KYSE-170 and -510 cells pretreated with or without CoCl₂₂₂₂₂ in different concentrations, followed by cytotoxicity (MTT) and migration assays. In parallel, expression of Hsp90, vascular endothelial growth factor (VEGF), hypoxia-inducible factor-1α (HIF-1α), and markers related to epithelial-mesenchymal transition (EMT) such as snail/E-cadherin, by immunoblot or ELISA while analyzing cell proliferation and migration of treated ESCC cells. Results CoCl₂ induced hypoxia was supported by induction of reactive oxygen species (ROS). CoCl₂ (200 μM) significantly suppressed cell viability and proliferation with a concomitant up-regulation of VEGF and HIF-1α in a dose-dependent fashion. In contrast, cell migration was significantly increased in response to CoCl₂ while down-regulating E-cadherin with a concomitant increase in Snail expression. 17-DMAG decreased expression of VEGF and HIF-1α while inhibiting cell migration and invasion. Conclusion Our data demonstrate that CoCl2 induced hypoxia promotes EMT and angiogensis, which are inhibited by 17-DMAG. These results suggest that hypoxia induced EMT and angiogensis is Hsp90 dependent in ESCC.

scholarly journals Role of serum angiopoietin-2 level in screening for esophageal squamous cell cancer and its precursors

2007 ◽  
Vol 120 (14) ◽  
pp. 1216-1219 ◽  
Author(s):  
Ying-zhi ZHOU ◽  
Xue-qiang FANG ◽  
Hao LI ◽  
Yu-tao DIAO ◽  
Yan-fang YANG ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
Esophageal Squamous Cell Cancer ◽  
Angiopoietin 2

Abstract B49: The role of LKB1 as a tumor suppressor in esophageal squamous cell cancer

2010 ◽  
Author(s):  
Ching Tzao ◽  
An-Li Hsueh ◽  
Ban-Hen Chen ◽  
Yaw-Wen Guo ◽  
Guang-Guan Sun, Shih-Chun Lee
Keyword(s):  
Tumor Suppressor ◽  
Squamous Cell ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
Esophageal Squamous Cell Cancer
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