scholarly journals Revealing Stroke Analysis Markers for Studying Heterogeneous Disease State of Stroke

2019 ◽  
Vol 4 ◽  
pp. 44-54
Author(s):  
Nikitha Rajendran ◽  
Mahadev Rao ◽  
Narayanan Rajendran
Keyword(s):  
Disease State

scholarly journals Early combination therapy with etanercept and methotrexate in JIA patients shortens the time to reach an inactive disease state and remission: results of a double-blind placebo-controlled trial

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Ekaterina Alexeeva ◽  
Gerd Horneff ◽  
Tatyana Dvoryakovskaya ◽  
Rina Denisova ◽  
Irina Nikishina ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Controlled Trial ◽  
Randomized Study ◽  
Primary Objective ◽  
Disease State ◽  
Inactive Disease ◽  
Open Label ◽  
Standard Regimen ◽  
Double Blind ◽  
Early Combination Therapy

Abstract Background Remission is the primary objective of treating juvenile idiopathic arthritis (JIA). It is still debatable whether early intensive treatment is superior in terms of earlier achievement of remission. The aim of this study was to evaluate the effectiveness of early etanercept+methotrexate (ETA+MTX) combination therapy versus step-up MTX monotherapy with ETA added in refractory disease. Methods A multi-centre, double-blind, randomized study in active polyarticular JIA patients treated with either ETA+MTX (n = 35) or placebo+MTX (n = 33) for up to 24 weeks, followed by a 24-week open-label phase. The efficacy endpoints included pedACR30 criteria improvement at week 12, inactive disease at week 24, and remission at week 48. Patients who failed to achieve the endpoints at week 12 or at week 24 escaped to open-label ETA+MTX. Safety was assessed at each visit. Results By intention-to-treat analysis, more patients in the ETA+MTX group reached the pedACR30 response at week 12 (33 (94.3%)) than in the placebo+MTX group (20 (60.6%); p = 0.001). At week 24, comparable percentages of patients reached inactive disease (11 (31.4%) vs 11 (33.3%)). At week 48, 11 (31.4%) and eight (24.2%) patients achieved remission. The median (+/−IQR) times to achieve an inactive disease state in the ETA+MTX and placebo+MTX groups were 24 (14–32) and 32 (24–40) weeks, respectively. Forty-four (74/100 patient-years) adverse events (AEs) were reported, leading to treatment discontinuation in 6 patients. Conclusions Early combination therapy with ETA+MTX proved to be highly effective compared to the standard step-up regimen. Compared to those treated with the standard regimen, more patients treated with a combination of ETA+MTX reached the pedACR30 response and achieved inactive disease and remission more rapidly.

scholarly journals Sex as a Prognostic Factor in Systematic Reviews: Challenges and Lessons Learned

2021 ◽  
Vol 11 (6) ◽  
pp. 441
Author(s):  
Elena Stallings ◽  
Alba Antequera ◽  
Jesús López-Alcalde ◽  
Miguel García-Martín ◽  
Gerard Urrútia ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Systematic Reviews ◽  
Lessons Learned ◽  
Disease State ◽  
Sex And Gender ◽  
Funding Agencies ◽  
And Gender ◽  
Baseline Factor ◽  
Clinical Domain ◽  
Made In

Sex is a common baseline factor collected in studies that has the potential to be a prognostic factor (PF) in several clinical areas. In recent years, research on sex as a PF has increased; however, this influx of new studies frequently shows conflicting results across the same treatment or disease state. Thus, systematic reviews (SRs) addressing sex as a PF may help us to better understand diseases and further personalize healthcare. We wrote this article to offer insights into the challenges we encountered when conducting SRs on sex as a PF and suggestions on how to overcome these obstacles, regardless of the clinical domain. When carrying out a PF SR with sex as the index factor, it is important to keep in mind the modifications that must be made in various SR stages, such as modifying the PF section of CHARMS-PF, adjusting certain sections of QUIPS and extracting data on the sex and gender terms used throughout the studies. In this paper, we provide an overview of the lessons learned from carrying out our reviews on sex as a PF in different disciplines and now call on researchers, funding agencies and journals to realize the importance of studying sex as a PF.

Oligometastatic Disease State Is Associated with Improved Local Control in Patients Undergoing Three or Five Fraction Spine Stereotactic Body Radiotherapy

2019 ◽  
Vol 122 ◽  
pp. e342-e348 ◽  
Author(s):  
Scott R. Silva ◽  
Adam Gliniewicz ◽  
Brendan Martin ◽  
Vikram C. Prabhu ◽  
Anand V. Germanwala ◽  
...  
Keyword(s):  
Local Control ◽  
Stereotactic Body Radiotherapy ◽  
Disease State ◽  
Oligometastatic Disease

AB0340 Fecal Calprotectin in Rheumatoid Disease, and Its Relation to Disease State: Table 1.

2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 917.1-917
Author(s):  
M. Tayel ◽  
M.H. Abdel Megid ◽  
H.H. Nouh ◽  
B. Rofaeil
Keyword(s):  
Fecal Calprotectin ◽  
Disease State ◽  
Rheumatoid Disease ◽  
State Table

scholarly journals Awareness of disease state without explicit knowledge of memory failure in transient global amnesia

Cortex ◽  
2012 ◽  
Vol 48 (8) ◽  
pp. 1079-1084 ◽  
Author(s):  
Mathieu Hainselin ◽  
Peggy Quinette ◽  
Béatrice Desgranges ◽  
Olivier Martinaud ◽  
Vincent de La Sayette ◽  
...  
Keyword(s):  
Explicit Knowledge ◽  
Transient Global Amnesia ◽  
Disease State ◽  
Memory Failure ◽  
Global Amnesia

Book ReviewLung Disease: State of the art

1978 ◽  
Vol 299 (12) ◽  
pp. 670-670
Author(s):  
William M. Thurlbeck
Keyword(s):  
State Of The Art ◽  
Disease State
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