scholarly journals Outcomes of Epidural Neuroplasty Utilizing Adhesiolysis by Means of Hydraulic and Mechanical force

2018 ◽  
Vol 3 ◽  
pp. 26-31 ◽  
Author(s):  
Isao Aoi ◽  
Huan-Chieh Chen ◽  
Tai-Ngar Lui ◽  
Tien-Jen Lin
Keyword(s):  
Mechanical Force

Recent developments of colorimetric mechanical sensors based on polymer composites

2020 ◽  
Vol 8 (35) ◽  
pp. 12036-12053
Author(s):  
Ezgi Inci ◽  
Gokhan Topcu ◽  
Tugrul Guner ◽  
Merve Demirkurt ◽  
Mustafa M. Demir
Keyword(s):  
Polymer Composites ◽  
Mechanical Action ◽  
Mechanical Force ◽  
Naked Eye ◽  
Recent Developments ◽  
Structural Deformations ◽  
Mechanical Sensors ◽  
Force Pressure

Colorimetric mechanical (force, pressure, strain, and impact) sensors allow naked-eye visualization of existing structural deformations of a system occurring upon application of a mechanical action.

scholarly journals Force-modulated reductive elimination from platinum(ii) diaryl complexes

2021 ◽  
Author(s):  
Yichen Yu ◽  
Chenxu Wang ◽  
Liqi Wang ◽  
Cai-Li Sun ◽  
Roman Boulatov ◽  
...  
Keyword(s):  
Transition State ◽  
Reductive Elimination ◽  
Mechanical Force ◽  
Elimination Reactions

The influence of mechanical force on the rates of model reductive elimination reactions depends on the structure of the force-transducing ligand and provides a measure of geometry changes upon reaching the transition state.

scholarly journals Mechanical force effect on the two-state equilibrium of the hyaluronan-binding domain of CD44 in cell rolling

2015 ◽  
Vol 112 (22) ◽  
pp. 6991-6996 ◽  
Author(s):  
Takashi Suzuki ◽  
Miho Suzuki ◽  
Shinji Ogino ◽  
Ryo Umemoto ◽  
Noritaka Nishida ◽  
...  
Keyword(s):  
Shear Stress ◽  
Conformational Change ◽  
Mechanical Force ◽  
Binding Domain ◽  
Terminal Region ◽  
Hematopoietic Progenitor Cell ◽  
High Shear ◽  
Cell Rolling ◽  
High Affinity ◽  
C Terminus

CD44 is the receptor for hyaluronan (HA) and mediates cell rolling under fluid shear stress. The HA-binding domain (HABD) of CD44 interconverts between a low-affinity, ordered (O) state and a high-affinity, partially disordered (PD) state, by the conformational change of the C-terminal region, which is connected to the plasma membrane. To examine the role of tensile force on CD44-mediated rolling, we used a cell-free rolling system, in which recombinant HABDs were attached to beads through a C-terminal or N-terminal tag. We found that the rolling behavior was stabilized only at high shear stress, when the HABD was attached through the C-terminal tag. In contrast, no difference was observed for the beads coated with HABD mutants that constitutively adopt either the O state or the PD state. Steered molecular dynamics simulations suggested that the force from the C terminus disrupts the interaction between the C-terminal region and the core of the domain, thus providing structural insights into how the mechanical force triggers the allosteric O-to-PD transition. Based on these results, we propose that the force applied from the C terminus enhances the HABD–HA interactions by inducing the conformational change to the high-affinity PD transition more rapidly, thereby enabling CD44 to mediate lymphocyte trafficking and hematopoietic progenitor cell homing under high-shear conditions.

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